Endocardite de Libmann-Sacks e anticoagulação oral

Brito, Fabiano Almeida; Tófani, Magali L M C; Tofani, Fábio Ávila; Kakehasi, Adriana Maria; Lanna, Cristina Costa Duarte; Carvalho, Marcos Alberto de

doi:10.1590/s0066-782x2004000400009

Cited by 10 publications

(4 citation statements)

References 23 publications

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“…But for primary prevention of thrombotic events whether low dose aspirin can help is a question yet to be answered with conflicting reports in various studies [19]. Complete resolution of Libman-sacks vegetation after initiation of warfarin therapy has been documented [20, 21]. …”

Section: Discussionmentioning

confidence: 99%

An Unusual Presentation of Lupus in a Pediatric Patient

Raj

2013

Case Reports in Pediatrics

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Systemic lupus erythematosus (SLE) is an autoimmune disease causing inflammatory tissue damage. Multiple organ damage can ensue with renal and neurological involvement carrying the worse prognosis. In this case report we present a 10-year-old African American girl who presented with abnormal choreiform movements, headache, weight loss, and fatigue. Detailed clinical examination with laboratory and imaging studies clinched the diagnosis of SLE. Echocardiogram revealed the presence of Libman-sacks endocarditis. Patient showed rapid resolution of symptoms with steroid therapy. A brief discussion on childhood onset lupus along with the varied clinical presentation is discussed.

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Section: Discussionmentioning

confidence: 99%

An Unusual Presentation of Lupus in a Pediatric Patient

Raj

2013

Case Reports in Pediatrics

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“…Libman-Sacks endocarditis (LSE) is defined by the presence of sterile vegetations on the heart valves. It is a rare cardiac manifestation of systemic lupus erythematosus, and the association of antiphospholipid syndrome is even rarer [ 1 ]. Manifestations may go unrecognized and progress to severe cardiac and systemic complications (cerebral and peripheral embolisms, valve dysfunction, superinfection), accentuating the risk of mortality [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Ischemic stroke revealing Libman-Sacks endocarditis: a case report

Yazidi,

Merzouk,

Rabii

et al. 2023

Journal of the Saudi Heart Association

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Libman-Sacks endocarditis (LSE) is a characteristic but rare feature of systemic lupus erythematosus (SLE), which can be found in association with antiphospholipid syndrome (APS), exposing the patient to an increased embolism risk, particularly the occurrence of ischemic stroke. We present a case involving a 64-year-old man who was admitted for ischemic stroke accompanied by a fever. Cardiac investigation revealed mitral vegetations along with severe mitral regurgitation. The diagnosis of Libman-Sacks endocarditis associated with SLE and APS was made after a laboratory work-up showing negative blood cultures and positive antibodies. This case underlines the importance of early diagnosis for better management of this pathology.

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“…A eliminação ou a redução máxima dos fatores de risco como DLP, HAS, obesidade, tabagismo, DM, sedentarismo e uso de estrógeno é necessária aos pacientes com SAF (18,19,24,25) .…”

Section: Introductionunclassified

“…A SAF é, atualmente, reconhecida como a trombofilia adquirida mais comum, causando alta recorrência de eventos trombóticos. Portanto, é imprescindível uma boa adesão ao tratamento para se evitar as conseqüências que podem ser graves ou fatais (24) .…”

Section: Introductionunclassified

A importância da intervenção nutricional na redução do peso corpóreo em pacientes com síndrome do anticorpo antifosfolípide

Klack

Carvalho

2008

Rev. Bras. Reumatol.

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ResumoObjetivo: Avaliar a eficácia da intervenção nutricional na redução do excesso de peso (EP), em pacientes com síndrome do anticorpo antifosfolípide (SAF). Métodos: Incluídos 40 pacientes, acima de 18 anos, com diagnóstico de SAF primária ou secundária, acompanhados no Serviço de Reumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP) e recrutados no período de outubro de 2005 a fevereiro de 2006. Foram coletados dados demográficos e realizados a revisão de prontuários, a mensuração de peso e da altura, o cálculo do índice de massa corpórea (IMC) atual e a adequação da dieta pelo IMC ideal. Foi realizada avaliação na primeira consulta e após intervalo mínimo de dois meses. Resultados: A média de idade dos pacientes foi de 41 anos, sendo 93% de mulheres. Os pacientes com SAF primária perfaziam 25%, com média de dois anos da doença. A trombose venosa ocorreu em 63%, arterial em 48% e manifestações obstétricas em 27%. Na primeira consulta, 68% apresentavam EP, 27% eram eutróficos e 5% estavam com baixo peso (BP). Após três meses de intervenção, os eutróficos mantiveram o peso e os de BP tornaram-se eutróficos, segundo o IMC. Interessantemente, entre os pacientes com EP (n = 27), 82% emagreceram, 14% engordaram e 4% se mantiveram. Especificamente, 11 pacientes apresentaram 1% a 3% de perda ponderal de peso, oito perderam de 4% a 7%, dois reduziram 8% a 9% e um reduziu 13,6% com o acompanhamento nutricional. Conclusão: Foi demonstrado no presente estudo que a intervenção nutricional conseguiu atingir metas para redução de peso, possibilitando diminuição no risco trombótico num curto período, sendo, portanto, uma modalidade terapêutica inicial e de eleição para corrigir o EP em pacientes com SAF.Palavras-chave: síndrome do anticorpo antifosfolípide, obesidade, trombose, síndrome metabólica, sobrepeso, excesso de peso. AbstRActObjective: To evaluate the efficacy of the nutricional intervention in the loss of the weight excess (WE), in patients with the antiphospholipid antibody syndrome (APS). Methods: Forty patients older than 18 years-old were included, with a diagnosis of either primary or secondary APS, followed at the the Rheumatology Outpatient Clinic from HCFM-USP and were recruited between october/2005 and february/06. Demographic data and patient records were reviewed. Body weight, height and current Body Mass Index (BMI) were recorded as well as diet adjustment according to ideal BMI. Patients were subjected to a first medical and nutritional evaluation and subsequently at least 2 months after baseline. Results: The mean age was 41 years old and 93% of the patients were female. The patients with primary APS were 25%, the mean disease duration was 2 years. Venous thrombosis occurred in 63%, arterial in 48% and obstetric events in 27%. In the first consultation 68% presented WE, 27% were euthrophic and 5% were of low weight (LW). After three months of intervention, the eutrophics maintained body weight while those with LW became eutrophic. Among the patients wit...

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Endocardite de Libmann-Sacks e anticoagulação oral

Cited by 10 publications

References 23 publications

An Unusual Presentation of Lupus in a Pediatric Patient

An Unusual Presentation of Lupus in a Pediatric Patient

Ischemic stroke revealing Libman-Sacks endocarditis: a case report

A importância da intervenção nutricional na redução do peso corpóreo em pacientes com síndrome do anticorpo antifosfolípide

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