Endocarditis due to Neisseria elongata: A case report and review of the literature

Youssef, Dima; Marroush, Tariq S.; Levine, Miriam; Sharma, Mamta

doi:10.18683/germs.2019.1176

Cited by 12 publications

(14 citation statements)

References 10 publications

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“…The main features of these cases are summarized in Table 1. [1][2][3][4][5] In our case, the presence of two predisposing factors prompted us to quickly seek endocarditis, which was confirmed by echocardiography. However, a review of the literature showed that N. elongata endocarditis can also occur in the absence of risk factors, which should encourage clinicians to be vigilant when dealing with N. elongata bacteremia.…”

Section: Discussionmentioning

confidence: 57%

“…However, a review of the literature showed that N. elongata endocarditis can also occur in the absence of risk factors, which should encourage clinicians to be vigilant when dealing with N. elongata bacteremia. [1][2][3][4][5] We noted other peculiarities of N. elongata endocarditis. First of all, they seem to affect people under 40 in almost half of the cases, including in the absence of underlying disease.…”

Section: Discussionmentioning

confidence: 68%

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Native mitral valve endocarditis due to Neisseria elongata following an untreated dental abscess

Foissac

Bergon

Mourguet

et al. 2020

Germs

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 68%

Native mitral valve endocarditis due to Neisseria elongata following an untreated dental abscess

Foissac

Bergon

Mourguet

et al. 2020

Germs

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“…A recent review of the literature concerning N. elongata endocarditis shows that 60% of patients with this infection were noted to require surgical intervention, mostly because of the development of complications such as congestive heart failure, systemic emboli, and abscess formation [1]. In our patient, the main indication for surgical intervention was the large size of the vegetation.…”

Section: Reference Range Admission Daymentioning

confidence: 61%

“…Neisseria elongata is a gram-negative rod-shaped bacterium that lives in the normal flora of the oropharynx [1]. The genus elongata is divided into three sub-species differentiated by biochemical characteristics: N. elongata, N. glycolytica, and N. nitroreducens [2].…”

Section: Introductionmentioning

confidence: 99%

Native Aortic Valve Endocarditis caused by Neisseria elongata in a Previously Healthy Patient

Haddad¹,

Tayyar²,

Gary³

et al. 2021

JCR

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Background: Neisseria elongata can behave as an opportunistic infection and can cause an array of diseases, including destructive endocarditis. Around 60% of cases of N. elongata infective endocarditis require surgical intervention. We report a case of N. elongata native aortic valve endocarditis in a previously healthy patient with no known risk factors who required valve replacement. Case Report: A 63-year-old female with no risk factors presented with fevers, headache and anorexia and was found to have Neisseria elongata endocarditis. Transesophageal echocardiography showed a 1.5×1.5 cm vegetation on aortic valve. Patient did well after aortic valve replacement surgery and a 6-week course of ceftriaxone. Conclusion: N. elongata endocarditis should be thought off in endocarditis cases, even with no apparent risk factors and cardiothoracic surgical evaluation is imperative due to destructive nature of this disease.

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“…N. elongata is a Gram-negative bacterium that is part of the normal flora of the oral cavity 26 . There are a number of case reports of infective endocarditis associated with colonization by N. elongata [26][27][28][29] . In addition, the bacterium has been implicated in some cases of osteomyelitis 29,30 .…”

Section: Discussionmentioning

confidence: 99%

Identification of microbial agents in tissue specimens of ocular and periocular sarcoidosis using a metagenomics approach

et al. 2021

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Background: Metagenomic sequencing has the potential to identify a wide range of pathogens in human tissue samples. Sarcoidosis is a complex disorder whose etiology remains unknown and for which a variety of infectious causes have been hypothesized. We sought to conduct metagenomic sequencing on cases of ocular and periocular sarcoidosis, none of them with previously identified infectious causes. Methods: Archival tissue specimens of 16 subjects with biopsies of ocular and periocular tissues that were positive for non-caseating granulomas were used as cases. Four archival tissue specimens that did not demonstrate non-caseating granulomas were also included as controls. Genomic DNA was extracted from tissue sections. DNA libraries were generated from the extracted genomic DNA and the libraries underwent next-generation sequencing. Results: We generated between 4.8 and 20.7 million reads for each of the 16 cases plus four control samples. For eight of the cases, we identified microbial pathogens that were present well above the background, with one potential pathogen identified for seven of the cases and two possible pathogens for one of the cases. Five of the eight cases were associated with bacteria (Campylobacter concisus, Neisseria elongata, Streptococcus salivarius, Pseudopropionibacterium propionicum, and Paracoccus yeei), two cases with fungi (Exophiala oligosperma, Lomentospora prolificans and Aspergillus versicolor) and one case with a virus (Mupapillomavirus 1). Interestingly, four of the five bacterial species are also part of the human oral microbiome. Conclusions: Using a metagenomic sequencing we identified possible infectious causes in half of the ocular and periocular sarcoidosis cases analyzed. Our findings support the proposition that sarcoidosis could be an etiologically heterogenous disease. Because these are previously banked samples, direct follow-up in the respective patients is impossible, but these results suggest that sequencing may be a valuable tool in better understanding the etiopathogenesis of sarcoidosis and in diagnosing and treating this disease.

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Endocarditis due to Neisseria elongata: A case report and review of the literature

Cited by 12 publications

References 10 publications

Native mitral valve endocarditis due to Neisseria elongata following an untreated dental abscess

Native mitral valve endocarditis due to Neisseria elongata following an untreated dental abscess

Native Aortic Valve Endocarditis caused by Neisseria elongata in a Previously Healthy Patient

Identification of microbial agents in tissue specimens of ocular and periocular sarcoidosis using a metagenomics approach

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