Endocrine and metabolic response to trauma in hypovolemic patients treated at a trauma center in Brazil

Bahten, Luiz Cv; Mauro, Fernando Ho; Domingos, Maria F; Scheffer, Paula H; Pagnoncelli, Bruno H; Wille, Marco Ar

doi:10.1186/1749-7922-3-28

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Insulin resistance of peripheral tissues also occurs, reducing the utilization of the available glucose and enhancing the hyperglycaemia [86]. The current finding in goats is in line with Bahten et al [72] who reported that hyperglycaemia develops in most human patients of T/H. Experimental data from in vitro studies suggest that insulin and sex hormones interact.…”

Section: Discussionsupporting

confidence: 89%

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Physiological Responses to Trauma-Haemorrhage (T/H) in Relation to Gender (Sex) in Adult Nubian Goats (Capra hircus)

Mohamed,

Alameen,

Abdelatif

2023

AJRAVS

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Aims:The effects of gender and trauma-haemorrhage (T/H) on thermoregulation and blood constituents were investigated in adult Nubian goats. Methodology: Twenty adult goats (10 males and 10 females) were used in the experiment. For each gender, animals were randomly assigned to two groups of 5 animals each, a control group and a treated group that was subjected to surgical soft tissue trauma (laparotomy) and 30% bleeding of calculated total blood volume. Thermoregulation, BW, haematological and serum biochemical parameters were monitored for 7 weeks. Results: The results showed significant increases in RR (p<0.05) and HR (p<0.001) following T/H in treated groups. The females had significantly lower rectal temperature Tr (p<0.05) and higher heart rate HR (p<0.

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Section: Discussionsupporting

confidence: 89%

“…In mice models , the ratio of lymphocytes decreased and both monocytes and neutrophils were not influenced by surgical trauma [64]. In contrast, in trauma-hypovolaemic human patients, the TLC, neutrophils and band neutrophil cells remained higher [72].…”

Section: Discussionmentioning

confidence: 95%

Physiological Responses to Trauma-Haemorrhage (T/H) in Relation to Gender (Sex) in Adult Nubian Goats (Capra hircus)

Mohamed,

Alameen,

Abdelatif

2023

AJRAVS

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“…In order to establish a valid trauma model, one must demonstrate change in several parameters that re ect the degree of organ damage and shock. Those parameters include hemodynamics, blood biochemical pro le, endocrine pro le and in our model also markers of hepatic tissue damage (23)(24)(25)(26). Also histopathologic samples from liver tissues in a setting of shock demonstrate certain changes such as central lobular necrosis (27).…”

Section: Discussionmentioning

confidence: 97%

Sodium Alginate as Treatment for Penetrating Abdominal Trauma- Feasibility Study.

Barsky

Ya’acov

Avraham

et al. 2020

Preprint

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Introduction: Penetrating abdominal injury is a major cause of death in trauma. It may cause hypovolemia leading to tissue hypoperfusion, direct organ damage and cytokine activation that cause inflammatory damage, all of which lead to death. Alginate is a natural anionic polysaccharide typically derived from brown algae. Sodium alginate hydrogel, a hemostatic agent, offers a platform for targeting both mechanical and biological injuries. The current study assessed the effect of a sodium alginate denoted VLVG (Very Low Viscosity (high) G alginate) following abdominal trauma in a swine model of penetrating abdominal injury. Methods: Seven anesthetized pigs were instrumented with catheters and abdominal trauma was introduced by laparoscopic hepatectomy. Ten minutes after the induction of hypovolemic shock, three animals were intra-abdominally administered with VLVG and four animals with saline (controls). During 8h of continuous monitoring, various hemodynamic and biochemical variables were measured and liver biopsies for histological evaluation were taken. In order to compare the study group to the control in a specific time a-parametric Mann-Whitney test was used, assessment of tendency during time Friedman's test for a-parametric variables was used. In order to compare the effect of the treatment (i.e. normal saline VS VLVG alginate) repeated measures ANOVA model was used, and the p value was calculated based on the Greenhouse-Geiser test. This research was approved by the Hebrew University of Jerusalem ethics Committee number: MD16148533. Results: VLVG-treated animals were more hemodynamically stable vs controls as reflected by their lower heart rate and higher blood pressure. They also had lower levels of liver enzymes and lactate and tissue damage. Conclusions: Our results in this pilot abdominal injury model show that VLVG might be a promising new agent. The superior hemostatic and biocompatibility efficiency along with its tissue preserving properties may turn VLVG in the future to a device that could be used in the pre-hospital setting to improve survival of abdominal trauma injuries.

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“…In order to establish a valid trauma model, we demonstrated changes in several vital components that reflect the degree of organ damage and shock. These include hemodynamic parameters, laboratory indices, such as blood and biochemical profile, endocrine profile, and markers of hepatic tissue damage [23][24][25][26] . Also, liver tissue samples in the setting of shock could demonstrate certain histopathological changes such as central lobular necrosis 27 , related to the level of injury.…”

Section: Discussionmentioning

confidence: 99%

A feasibility study using sodium alginate injection for penetrating abdominal trauma in a swine model

Barsky

Ya’acov

Avraham

et al. 2022

Sci Rep

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Penetrating abdominal injury is a major cause of death in trauma. Sodium alginate hydrogel, a hemostatic agent, offers a platform for targeting both mechanical and biological injuries. The current study assessed the effect of Very Low Viscosity (high) G (VLVG) alginate following abdominal trauma in a swine model of penetrating abdominal injury. Seven anesthetized pigs were instrumented with invasive monitoring catheters and abdominal trauma was introduced by laparoscopic hepatectomy. Ten minutes after the induction of hypovolemic shock, three animals were intra-abdominally administered with VLVG alginate (study group) and four animals with saline (control group). During 8 h of continuous monitoring, various hemodynamic and biochemical variables were measured and liver biopsies for histological evaluation were taken. Hemodynamically, VLVG alginate-treated animals were more stable than controls, as reflected by their lower heart rate and higher blood pressure (p < 0.05 for both). They also had lower levels of liver enzymes and lactate, and less histopathological damage. We show that VLVG alginate might be a promising new agent for reducing penetrating intra-abdominal injury, with hemostatic and biocompatibility efficiency, and tissue preserving properties. Future effort of integrating it with a dispersal device may turn it into a valuable pre-hospital emergency tool to improve survival of trauma casualties.

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Endocrine and metabolic response to trauma in hypovolemic patients treated at a trauma center in Brazil

Abstract: Background: The metabolic changes in trauma patients with shock contribute directly to the survival of the patient. To understand these changes better, we made a rigorous analysis of the variations in the main examinations requested for seriously polytraumatized patients.

Cited by 7 publications

References 10 publications

Physiological Responses to Trauma-Haemorrhage (T/H) in Relation to Gender (Sex) in Adult Nubian Goats (Capra hircus)

Physiological Responses to Trauma-Haemorrhage (T/H) in Relation to Gender (Sex) in Adult Nubian Goats (Capra hircus)

Sodium Alginate as Treatment for Penetrating Abdominal Trauma- Feasibility Study.

A feasibility study using sodium alginate injection for penetrating abdominal trauma in a swine model

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