Endocrine disorders and the neurologic manifestations

Yu, Jeesuk

doi:10.6065/apem.2014.19.4.184

Cited by 34 publications

(9 citation statements)

References 49 publications

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“…For example, hypocalcemia can arise at any age and affects the majority (>60%) of adult patients [Cheung et al, 2014b; McDonald-McGinn et al, 2015]. While often asymptomatic, hypocalcemia can be associated with neuropsychiatric symptoms, including irritability, fatigue, tremor, muscle cramps, stiffness, and seizures [Bassett et al, 2011; Kao et al, 2004; Weinzimer 2001; Yu 2014]. Notably, some anticonvulsants, e.g., carbamazepine, phenytoin, may diminish vitamin D levels [Teagarden et al, 2014], potentially increasing the risk of hypocalcemia [Cheung et al, 2014b] and its associated complications.…”

Section: General Principles Of Management For Neuropsychiatric Disordmentioning

confidence: 99%

Neuropsychiatric expression and catatonia in 22q11.2 deletion syndrome: An overview and case series

Butcher

Boot

Lang

et al. 2018

American J of Med Genetics Pt A

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Individuals with 22q11.2 deletion syndrome (22q11.2DS) are at elevated risk of developing treatable psychiatric and neurological disorders, including anxiety disorders, schizophrenia, seizures, and movement disorders, often beginning in adolescence or early to mid-adulthood. Here, we provide an overview of neuropsychiatric features associated with 22q11.2DS in adulthood. Results of a new case series of 13 individuals with 22q11.2DS and catatonic features together with 5 previously reported cases support a potential association of this serious psychomotor phenotype with the 22q11.2 deletion. As in the general population, catatonic features in 22q11.2DS occurred in individuals with schizophrenia, other psychotic and non-psychotic psychiatric disorders, and neurological disorders like Parkinson's disease. We place the results in the context of an updated review of catatonia in other genetic conditions. The complex neuropsychiatric expression and risk profile of 22q11.2DS highlights the need to consider co-morbid factors and provide care tailored to the individual patient. The results reinforce the need for periodic monitoring for the emergence of psychiatric and neurological manifestations including catatonic features. Pending further research, enhanced recognition and informed anticipatory care promise to facilitate the early diagnosis that allows for timely implementation and optimization of effective treatments.

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Section: General Principles Of Management For Neuropsychiatric Disordmentioning

confidence: 99%

Neuropsychiatric expression and catatonia in 22q11.2 deletion syndrome: An overview and case series

Butcher

Boot

Lang

et al. 2018

American J of Med Genetics Pt A

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“…It has been reported that SARS-CoV-2 can cross the blood-brain barrier (BBB) and infect the ACE2 expressing neurons and glial cells, thereby leading to neuroinflammation and neuropathogenesis in the brain regions including the hypothalamus that controls various physiological functions like maintenance of the body temperature and hormonal balance [8,12,17,25,26]. Dysregulation of endocrine functions is an important clinical issue as it is related to different disorders including hypothyroidism, hypogonadism, anxiety, stress, and depression that are clearly evident in COVID-19 cases [27][28][29][30]. While the possible impact of COVID-19 on the abnormal hypothalamic-pituitaryadrenal (HPA) axis has been speculated [31], SARS-CoV-2mediated dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis remains obscure.…”

Section: Introductionmentioning

confidence: 99%

Testicular Atrophy and Hypothalamic Pathology in COVID-19: Possibility of the Incidence of Male Infertility and HPG Axis Abnormalities

et al. 2021

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“…Patients with endocrine disorders may experience neurologic diseases [6]. Among endocrine disorders, thyroid disorders have been known as risk factors for progressive cognitive impairment development, either in the form of hyperthyroidism or hypothyroidism [7].…”

Section: Introductionmentioning

confidence: 99%

Thyroid Disorders and Development of Cognitive Impairment: A Review Study

Khaleghzadeh‐Ahangar¹,

Talebi²,

Mohseni‐Moghaddam³

2021

Neuroendocrinology

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Dementia is a neurological disorder that is spreading with increasing human lifespan. In this neurological disorder, memory and cognition are declined and eventually impaired. Various factors can be considered as the background of this disorder, one of which is endocrine disorders. Thyroid hormones are involved in various physiological processes in the body; one of the most important of them is neuromodulation. Thyroid disorders, including hyperthyroidism or hypothyroidism, can affect the nervous system and play a role in the development of dementia. Despite decades of investigation, the nature of the association between thyroid disorders and cognition remains a mystery. Given the enhancing global burden of dementia, the principal purpose of this study was to elucidate the association between thyroid disturbances as a potentially modifiable risk factor of cognitive dysfunction. In this review study, we have tried to collect almost all of the reported mechanisms demonstrating the role of hypothyroidism and hyperthyroidism in the pathogenesis of dementia.

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Endocrine disorders and the neurologic manifestations

Cited by 34 publications

References 49 publications

Neuropsychiatric expression and catatonia in 22q11.2 deletion syndrome: An overview and case series

Neuropsychiatric expression and catatonia in 22q11.2 deletion syndrome: An overview and case series

Testicular Atrophy and Hypothalamic Pathology in COVID-19: Possibility of the Incidence of Male Infertility and HPG Axis Abnormalities

Thyroid Disorders and Development of Cognitive Impairment: A Review Study

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