Endocrine-Disrupting Chemicals and Insulin Resistance in Children

Rotondo, Eleonora; Chiarelli, Francesco

doi:10.3390/biomedicines8060137

Cited by 24 publications

(14 citation statements)

References 121 publications

(153 reference statements)

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“…There is a growing body of evidence that EDCs target several pathophysiologic features of GDM, such as weight gain, insulin resistance, and pancreatic

-cell function [ 84 , 107 , 108 ]. EDCs influence the activity of peroxisome proliferator-activated receptors, which are crucially involved in glucose metabolism and energy homeostasis.…”

Section: General Aspects Of Endocrine Disrupting Chemicalsmentioning

confidence: 99%

Epigenetic Modifications Associated with Exposure to Endocrine Disrupting Chemicals in Patients with Gestational Diabetes Mellitus

Kunysz

Mora-Janiszewska

Darmochwał-Kolarz

2021

IJMS

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Gestational diabetes mellitus (GDM) remains a significant clinical and public health issue due to its increasing prevalence and the possibility for numerous short- and long-term complications. The growing incidence of GDM seems to coincide with the widespread use of endocrine disrupting chemicals (EDCs). The extensive production and common use of these substances in everyday life has resulted in constant exposure to harmful substances from the environment. That may result in epigenetic changes, which may manifest themselves also after many years and be passed on to future generations. It is important to consider the possible link between environmental exposure to endocrine disrupting chemicals (EDCs) during pregnancy, epigenetic mechanisms and an increased risk for developing gestational diabetes mellitus (GDM). This manuscript attempts to summarize data on epigenetic changes in pregnant women suffering from gestational diabetes in association with EDCs. There is a chance that epigenetic marks may serve as a tool for diagnostic, prognostic, and therapeutic measures.

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“…There is a growing body of evidence that EDCs target several pathophysiologic features of GDM, such as weight gain, insulin resistance, and pancreatic

-cell function [ 84 , 107 , 108 ]. EDCs influence the activity of peroxisome proliferator-activated receptors, which are crucially involved in glucose metabolism and energy homeostasis.…”

Section: General Aspects Of Endocrine Disrupting Chemicalsmentioning

confidence: 99%

Epigenetic Modifications Associated with Exposure to Endocrine Disrupting Chemicals in Patients with Gestational Diabetes Mellitus

Kunysz

Mora-Janiszewska

Darmochwał-Kolarz

2021

IJMS

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“…Studies investigating EDCs’ impact on fetal–placental epigenetics in human pregnancy are sparse because of the ethical issues associated to the collection of samples during the first trimester of pregnancy. EDCs induce genome alterations in pregnancy or early life and enchain in a decreased expression of pancreatic/duodenal homeobox 1 transcription factor gene (PDX-1) associated with an increase in T2D (review in [ 157 ]), suggesting that in utero exposure to impaired nutrition is a risk for obesity and diabetes progression in adulthood. EDCs confine the stock of essential metabolic substrates to the fetus and cause intrauterine growth retardation, presenting as fetal starvation and the metabolic basis that triggers diabetes progression in PDX-1.…”

Section: Hypothesis Of Different Mechanisms Leading To MDmentioning

confidence: 99%

Early Life Exposure to Food Contaminants and Social Stress as Risk Factor for Metabolic Disorders Occurrence?—An Overview

Guzylack‐Piriou

Ménard

2021

Biomolecules

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The global prevalence of obesity has been increasing in recent years and is now the major public health challenge worldwide. While the risks of developing metabolic disorders (MD) including obesity and type 2 diabetes (T2D) have been historically thought to be essentially driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. Based on human epidemiological and pre-clinical experimental studies, this overview questioned the role of non-nutritional components as contributors to the epidemic of MD with a special emphasis on food contaminants and social stress. This overview examines the impact of early life adverse events (ELAE) focusing on exposures to food contaminants or social stress on weight gain and T2D occurrence in the offspring and explores potential mechanisms leading to MD in adulthood. Indeed, summing up data on both ELAE models in parallel allowed us to identify common patterns that appear worthwhile to study in MD etiology. This overview provides some evidence of a link between ELAE-induced intestinal barrier disruption, inflammation, epigenetic modifications, and the occurrence of MD. This overview sums up evidence that MD could have developmental origins and that ELAE are risk factors for MD at adulthood independently of nutritional status.

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“…Furthermore, data obtained in human and different cell lines show that BPA interferes with thyroid hormones synthesis, secretion, and signaling. Due to its anti-androgenic action, BPA works as an agonist on estrogen receptors and antagonist on androgen receptors [ 35 ]. Recently, it has been shown that BPA interferes with spermatogenesis and impairs male reproductive function.…”

Section: Introductionmentioning

confidence: 99%

Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease

Cimmino

Fiory

Perruolo

et al. 2020

IJMS

274

118

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Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, and dental materials. BPA can contaminate food, beverage, air, and soil. It accumulates in several human tissues and organs and is potentially harmful to human health through different molecular mechanisms. Due to its hormone-like properties, BPA may bind to estrogen receptors, thereby affecting both body weight and tumorigenesis. BPA may also affect metabolism and cancer progression, by interacting with GPR30, and may impair male reproductive function, by binding to androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, and HAND2, are involved in BPA action on fat and liver homeostasis, the cardiovascular system, and cancer. Finally, epigenetic changes, such as DNA methylation, histones modification, and changes in microRNAs expression contribute to BPA pathological effects. This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.

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Endocrine-Disrupting Chemicals and Insulin Resistance in Children

Cited by 24 publications

References 121 publications

Epigenetic Modifications Associated with Exposure to Endocrine Disrupting Chemicals in Patients with Gestational Diabetes Mellitus

Epigenetic Modifications Associated with Exposure to Endocrine Disrupting Chemicals in Patients with Gestational Diabetes Mellitus

Early Life Exposure to Food Contaminants and Social Stress as Risk Factor for Metabolic Disorders Occurrence?—An Overview

Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease

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