2020
DOI: 10.1002/rmb2.12326
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Endocrine‐disrupting chemicals and male reproductive health

Abstract: A number of studies have reported a deterioration in sperm quality over the past 50 years, 1,2 and a variety of factors have been implicated in this decline, including environmental and lifestyle factors. Data from animal and human studies suggest that endocrine-disrupting chemicals are associated in the etiopathogenesis with harmful effects on male reproductive health. 3 Furthermore, recent meta-analysis has suggested that EDCs not only have a deleterious effect on sperm quality but may also be associated wit… Show more

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Cited by 106 publications
(47 citation statements)
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References 84 publications
(61 reference statements)
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“…EDCs affect the reproductive system and the cellular processes in both sexes, leading to congenital abnormalities and infertility [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Mechanisms through which EDCs exert their pathophysiological effects have not yet been fully elucidated in human studies [ 19 ]. Despite a growing literature on couple exposure to non-persistent EDCs and fecundability, evidence for associations between biologically measured exposures and time to pregnancy is limited with equivocal results that do not preclude action, given the documented endocrine disrupting effects on other reproductive outcomes/fetal development [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…EDCs affect the reproductive system and the cellular processes in both sexes, leading to congenital abnormalities and infertility [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Mechanisms through which EDCs exert their pathophysiological effects have not yet been fully elucidated in human studies [ 19 ]. Despite a growing literature on couple exposure to non-persistent EDCs and fecundability, evidence for associations between biologically measured exposures and time to pregnancy is limited with equivocal results that do not preclude action, given the documented endocrine disrupting effects on other reproductive outcomes/fetal development [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…Early-life exposures have also been associated with developmental abnormalities and may increase the risk of several diseases later-in-life [ 4 ]. In adulthood, increasing incidences of several human reproductive disorders, such as testicular cancers and reduced sperm counts, may be partially attributed to an increased exposure to environmental EDCs that have estrogenic activity [ 7 , 8 , 9 , 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…In this paper, we evaluated whether the use of D-Asp may have a protective role in preventing the testicular injury produced by the exposure to EDS, a toxicant that selectively destroys LC. Indeed, it must be considered that recently, some pollutants, such as cadmium [ 41 , 42 , 43 ] and BPA [ 44 , 45 , 46 ] may act as endocrine disrupters and/or toxicants that specifically affect gametogenesis leading to the production of low-quality gametes and, consequently, giving rise to a low rate of reproduction [ 47 , 48 ]. Firstly, to evaluate the effectiveness of the treatments, we measured the serum T levels.…”
Section: Resultsmentioning
confidence: 99%