Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

Street, Maria Elisabeth; Audouze, Karine; Legler, Juliette; Sone, Hirohito

doi:10.3390/ijms22020933

Cited by 26 publications

(14 citation statements)

References 28 publications

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“…As per some research work, central nervous system is also affected by EDCs. The AhR mainly belongs to bHLH-PHS protein (Street et al 2021). This AhR is mainly acts as a ligand activated transcription factor.…”

Section: Mechanistic Approach Of Edcsmentioning

confidence: 99%

Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human

2022

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At present, endocrine disrupting chemicals (EDCs) have gained attention in human pathophysiology, and many studies have yet been conducted to explain the mechanism of these chemical compounds on endocrine and reproductive dysfunctions. In human the maximum studies focus towards the exposure to endocrine disrupting chemicals and their disorders on different endocrine axises though sufficient information are not available on reproductive systems in human. A huge number of EDCs resulting the interference of the normal functions of hypothalamic-pituitary–gonadal axis. There are several types of EDCs like pesticides, heavy metals, food additives and contaminants which are responsible to create negative impact on metabolism and alteration of the homeostasis of tissue and promoting different disorders such as diabetes, obesity, cardiovascular disease, infertility etc. Genomic and nongenomic mechanisms which have been proposed to clarify these complications together with occupational or environmental exposure together, the lack of in depth studies, and the occurrence of different confusing factors have prohibited to establish the causal relationship between the reproductive cum endocrine disorders and exposure to specific EDCs so far. The aim of the manuscript is to review the scientific literature exists so far on the different hazardous effects of EDCs on reproductive health focusing the up to date mode of actions of major EDCs in this concerns.

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Section: Mechanistic Approach Of Edcsmentioning

confidence: 99%

Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human

2022

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“…Synthetic EDCs are found in common industrial products such as pesticides, fungicides, flame retardants, plastics, food wrappers, solvents, and metals. Both in vitro and in vivo studies have shown that synthetic EDCs exert effects on multiple systems including the reproductive system, the central nervous system, the immune system, and on metabolic function ( 20 ). In addition to endocrine pathways there are many non-hormonal cellular signaling pathways that could potentially be disrupted by chemical exposures.…”

Section: Edcs and Obesogensmentioning

confidence: 99%

Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action

Mohajer

Checkcinco

et al. 2021

Front. Endocrinol.

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Adult and childhood obesity have reached pandemic level proportions. The idea that caloric excess and insufficient levels of physical activity leads to obesity is a commonly accepted answer for unwanted weight gain. This paradigm offers an inconclusive explanation as the world continually moves towards an unhealthier and heavier existence irrespective of energy balance. Endocrine disrupting chemicals (EDCs) are chemicals that resemble natural hormones and disrupt endocrine function by interfering with the body’s endogenous hormones. A subset of EDCs called obesogens have been found to cause metabolic disruptions such as increased fat storage, in vivo. Obesogens act on the metabolic system through multiple avenues and have been found to affect the homeostasis of a variety of systems such as the gut microbiome and adipose tissue functioning. Obesogenic compounds have been shown to cause metabolic disturbances later in life that can even pass into multiple future generations, post exposure. The rising rates of obesity and related metabolic disease are demanding increasing attention on chemical screening efforts and worldwide preventative strategies to keep the public and future generations safe. This review addresses the most current findings on known obesogens and their effects on the metabolic system, the mechanisms of action through which they act upon, and the screening efforts through which they were identified with. The interplay between obesogens, brown adipose tissue, and the gut microbiome are major topics that will be covered.

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“…EURION is a cluster of eight research projects, funded under the European Commission’s Horizon 2020 Research and Innovation Programme, focusing on developing new testing and screening methods identifying EDs and studying their effects on metabolism ( Audouze et al, 2020 ; Küblbeck et al, 2020 ; Legler et al, 2020 ), female reproductive toxicity ( van Duursen et al, 2020 ), developmental neurotoxicity ( Lupu et al, 2020 ) and thyroid-mediated toxicity ( Holbech et al, 2020 ; Kortenkamp et al, 2020 ; Moroni et al, 2020 ). AOP development is an integral part of each of these projects ( Street et al, 2021 ).…”

Section: Eurion Activities Relevant To Aop Developmentmentioning

confidence: 99%

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities

et al. 2021

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Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

Abstract: Endocrine disrupting chemicals (EDCs) are exogenous chemicals which can disrupt any action of the endocrine system, and are an important class of substances which play a role in the Developmental Origins of Health and Disease (DOHaD) [...]

Cited by 26 publications

References 28 publications

Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human

Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human

Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities

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