Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells

Yawer, Affiefa; Sychrová, Eliška; Labohá, Petra; Raška, Jan; Jambor, Tomáš; Babica, Pavel; Sovadinová, Iva

doi:10.1016/j.taap.2020.115177

Cited by 28 publications

(17 citation statements)

References 93 publications

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“…Spermatogenesis requires the precise regulation of the somatic cell populations, Leydig, Sertoli and peritubular myoid cells [29]. Altogether with the germ cells, they represent the major testicular cell types [30]. Despite the different characteristics and functions of each cell type, they are all susceptible to internal and external factors, such as, environmental factors, hormonal deregulation, diseases and oxidative stress [30][31][32].…”

Section: Effects and Mechanism Of Action Of Pesticides On Testicular Somatic Cellsmentioning

confidence: 99%

“…Altogether with the germ cells, they represent the major testicular cell types [30]. Despite the different characteristics and functions of each cell type, they are all susceptible to internal and external factors, such as, environmental factors, hormonal deregulation, diseases and oxidative stress [30][31][32]. Considering specifically pesticides, they can damage the male reproductive system in several ways: (i) reproductive toxicity with direct damage to cell's structure; (ii) changes in DNA structure, leading to gene mutations that may cause birth defects or inability to conceive; (iii) epigenetic effects induced by changing the way genes are expressed.…”

Section: Effects and Mechanism Of Action Of Pesticides On Testicular Somatic Cellsmentioning

confidence: 99%

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Pesticides and Male Fertility: A Dangerous Crosstalk

et al. 2021

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In recent decades, an increasing incidence of male infertility has been reported. Interestingly, and considering that pesticides have been used for a long time, the high incidence of this pathological state is concomitant with the increasing use of these chemicals, suggesting they are contributors for the development of human infertility. Data from literature highlight the ability of certain pesticides and/or their metabolites to persist in the environment for long periods of time, as well as to bioaccumulate in the food chain, thus contributing for their chronic exposure. Furthermore, pesticides can act as endocrine disrupting chemicals (EDCs), interfering with the normal function of natural hormones (which are responsible for the regulation of the reproductive system), or even as obesogens, promoting obesity and associated comorbidities, like infertility. Several in vitro and in vivo studies have focused on the effects and possible mechanisms of action of these pesticides on the male reproductive system that cause sundry negative effects, even though through diverse mechanisms, but all may lead to infertility. In this review, we present an up-to-date overview and discussion of the effects, and the metabolic and molecular features of pesticides on somatic cells and germinal tissues that affect germ cell differentiation.

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Section: Effects and Mechanism Of Action Of Pesticides On Testicular Somatic Cellsmentioning

confidence: 99%

Section: Effects and Mechanism Of Action Of Pesticides On Testicular Somatic Cellsmentioning

confidence: 99%

Pesticides and Male Fertility: A Dangerous Crosstalk

et al. 2021

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“…An equally likely scenario is that phthalates disrupt Leydig cell differentiation or maintenance, which consequently lead to compromised androgen production. Recent studies suggests that phthalates, and indeed several other EDCs, can disrupt Leydig cell gap junctions and intercellular signaling ( Yawer et al, 2020 , Di Lorenzo et al, 2020 ). This ultimately means that it can be the Leydig cells themselves that are rendered dysfunctional by phthalate exposure and not steroidogenesis per se .…”

Section: Perspectivesmentioning

confidence: 99%

Hedgehog signal disruption, gonadal dysgenesis and reproductive disorders: Is there a link to endocrine disrupting chemicals?

Johansson

Svingen

2020

Current Research in Toxicology

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“…3 Recent studies have suggested that the development and function of LCs are highly susceptible to EDC exposure. 4,5 Bisphenol A (BPA) and 4-nonylphenol (NP) are known as typical EDCs. BPA is a key raw material used to produce resins and polymers, containing polycarbonate, epoxy, and polyacrylate, which are widely used in food packaging, baby bottles, bottles, and dental sealants.…”

Section: -Nonylphenol Bisphenol a Ftir Spectroscopy Leydig Cells Mult...mentioning

confidence: 99%

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

Xia

Guo

et al. 2022

Environmental Toxicology

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Bisphenol A (BPA) and 4-nonylphenol (NP) are well-known endocrine-disrupting chemicals (EDCs) that have been proven to affect Leydig cell (LC) functions and testosterone production, but whether BPA and NP have multi-and transgenerational biochemical effects on Leydig cells (LCs) is unknown. Fourier transform infrared (FTIR) spectroscopy is a powerful analytical technique that enables label-free and non-destructive analysis of the tissue specimen. Herein we employed FTIR coupled with chemometrics analysis to identify biomolecular changes in testicular interstitial (Leydig) cells of rats after chronic exposure to low doses of BPA and NP. Cluster segregations between exposed and control groups were observed based on the fingerprint region of 1800-900 cm À1 in all generations. The main biochemical alterations for segregation were amide I, amide II and nucleic acids. BPA and NP single and coexposure induced significant differences in the ratio of amide I to amide II compared to the corresponding control group in all generations. BPA exposure resulted in remarkable changes of cellular gene transcription and DNA oxidative damage across all generations. Direct exposure to BPA, NP, and BPA&NP of F0 and F1 generations could significantly decrease lipid accumulation in LCs in the F2 and F3 generations.The overall findings revealed that single or co-exposure to BPA and NP at environmental concentrations affects the biochemical structures and properties of LCs.

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Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells

Cited by 28 publications

References 93 publications

Pesticides and Male Fertility: A Dangerous Crosstalk

Pesticides and Male Fertility: A Dangerous Crosstalk

Hedgehog signal disruption, gonadal dysgenesis and reproductive disorders: Is there a link to endocrine disrupting chemicals?

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

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