Endocrine disrupting compounds: Can they target the immune system of fish?

Casanova-Nakayama, Ayako; Wenger, Michael; Burki, Richard; Eppler, Elisabeth; Krasnov, Aleksei; Segner, Helmut

doi:10.1016/j.marpolbul.2011.05.007

Cited by 86 publications

(44 citation statements)

References 55 publications

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“…The stickleback is a well described model fish species used to assess the endocrine disruptor potential of EDCs due to the presence of both estrogenic (vitellogenin) and androgenic (spiggin) end-points (Katsiadaki et al, 2002;Hahlbeck et al, 2004;Jolly et al, 2006;Sanchez et al, 2008;Le Mer et al, 2013). Nevertheless, as showed by (Casanova-Nakayama et al, 2011), current data are too limited to inform conclusive ideas of the in vivo EDC impact mechanisms on fish immune function. Thus, after determining the optimal test conditions necessary to analyze fish splenic immune responses, we proposed here some ex vivo assays.…”

Section: Introductionmentioning

confidence: 99%

“…Due to their potential hazard on aquatic wildlife (Canesi et al, 2007;Casanova-Nakayama et al, 2011) and their expanding detection in freshwater (Peck et al, 2004;Pal et al, 2010) and marine (Braga et al, 2005;Pinto et al, 2005) environments, research on the effects of EDCs in the past few decades has grown rapidly. In this context, fish are considered as good indicators to assess the toxicity of endocrine disrupting chemicals (Jin et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…(Hinfray et al, 2006;Kallivretaki et al, 2006;Cheshenko et al, 2008). Despite the fact that immune and reproductive systems may interact in a bidirectional way (Ansar Ahmed, 2000;Engelsma et al, 2002), endocrine disruption effects on the fish immune system have received limited attention and more concern has been made on estrogenic compounds (Jin et al, 2010;Casanova-Nakayama et al, 2011). Recently, some studies demonstrated that environmental estrogens may also affect the immune system of aquatic wildlife (Canesi et al, 2007;Casanova-Nakayama et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Despite the fact that immune and reproductive systems may interact in a bidirectional way (Ansar Ahmed, 2000;Engelsma et al, 2002), endocrine disruption effects on the fish immune system have received limited attention and more concern has been made on estrogenic compounds (Jin et al, 2010;Casanova-Nakayama et al, 2011). Recently, some studies demonstrated that environmental estrogens may also affect the immune system of aquatic wildlife (Canesi et al, 2007;Casanova-Nakayama et al, 2011). For example, Liney et al (2006) found that estrogen-active effluents changed the structure and function of the reproductive system of the roach, Rutilus rutilus, at higher concentration than those who impaired the immune function.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the chosen concentrations were around current environmental concentrations of EDC detected in sewage-treatment plants effluents, rivers and seawater (Desbrow et al, 1998;OSPAR, 2001). The spleen tissue was chosen as it is an important target for steroids (Casanova-Nakayama et al, 2011;Milla et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.)

Bado‐Nilles¹,

Técher²,

Porcher³

et al. 2014

Environmental Toxicology and Pharmacology

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Today, the list of endocrine disrupting compounds (EDCs) in freshwater and marine environments that mimic or block endogenous hormones is expanding at an alarming rate. As immune and reproductive systems may interact in a bidirectional way, some authors proposed the immune capacities as attractive markers to evaluate the hormonal potential of environmental samples. Thus, the present work proposed to gain more knowledge on direct biological effects of natural and EDCs on female fish splenic leucocyte non-specific immune activities by using ex vivo assays. After determining the optimal required conditions to analyze splenic immune responses, seven different EDCs were tested ex vivo at 0.01, 1 and 100nM over 12h on the leucocyte functions of female three-spined stickleback, Gasterosteus aculeatus. In summary, we found that natural hormones acted as immunostimulants, whilst EDCs were immunosuppressive.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.)

Bado‐Nilles¹,

Técher²,

Porcher³

et al. 2014

Environmental Toxicology and Pharmacology

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Antinutrients

Krogdahl¹,

Bakke²

2015

Dietary Nutrients, Additives, and Fish Health

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Sensitive periods for 17β‐estradiol exposure during immune system development in sea bass head kidney

Seemann

Knigge

Duflot

et al. 2015

J of Applied Toxicology

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An increasing body of evidence suggests that sex steroids play an important role in the development and regulation of vertebrate immune defense. Therefore, compounds with estrogenic activity may influence the immune system via receptor-mediated pathways. The presence of estrogen receptors in immune cells and organs during the early stages of development may indicate that female steroid hormones are involved in the maturation of the fish immune system. This is of particular importance, as some marine fish are probably exposed to sources of exogenous estrogens while they reside in their estuarine nursery grounds. In this study, the influence of 17β-estradiol (E2) on estrogen receptor and cytokine gene expression was assessed in juvenile sea bass (Dicentrarchus labrax) together with characterization of the head kidney leukocyte populations and corresponding phagocytic activity during organ regionalization from 98 to 239 dph. E2 exposure, beginning at 90 dph resulted in indirect and delayed modifications of interleukin 1β and estrogen receptor α gene expression, which may affect B-lymphocyte proliferation in the sea bass head kidney. The E2 treatment of 120 dph fish led to an increase in estrogen receptor β2 and a decrease in transforming growth factor β1 gene expression, which coincided with decreased phagocytic activity of head kidney lymphocytes and monocytes/macrophages. Additionally, these changes were observed during developmental periods described as critical phases for B-lymphocyte development in mammals. Consequently, exogenous estrogens have the potential to modify the innate immune response in juvenile sea bass and to exert detrimental effects on head kidney development. Copyright © 2015 John Wiley & Sons, Ltd.

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Endocrine disrupting compounds: Can they target the immune system of fish?

Cited by 86 publications

References 55 publications

Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.)

Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.)

Antinutrients

Sensitive periods for 17β‐estradiol exposure during immune system development in sea bass head kidney

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