Endocrine-disrupting effect of the ultraviolet filter benzophenone-3 in zebrafish, <i>Danio rerio</i>

Kinnberg, Karin Lund; Petersen, Gitte I.; Albrektsen, Mette; Minghlani, Mite; Awad, Suad Mohamud; Holbech, Bente Frost; Green, John W.; Bjerregaard, Poul; Holbech, Henrik

doi:10.1002/etc.3129

Cited by 88 publications

(36 citation statements)

References 31 publications

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“…Benzophenone-3 (oxybenzone, BP3) is commonly used as a UV-filter in cosmetics such as sunscreens, but also as a light stabilizer in plastics such as PE. In addition, BP3 has repeatedly been reported to act as an endocrine disrupting chemical interfering with reproduction and sex hormone signaling in fish and mammals (Kim and Choi, 2014;Kinnberg et al, 2015;Rodríguez-Fuentes et al, 2015). BP3 shows low degradation rates in surface waters (Kim and Choi, 2014) and-due to its lipophilicity (log Kow 4.0)-may bioaccumulate in biota.…”

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confidence: 99%

Multi-Laboratory Hazard Assessment of Contaminated Microplastic Particles by Means of Enhanced Fish Embryo Test With the Zebrafish (Danio rerio)

Cormier

Batel

Cachot

et al. 2019

Front. Environ. Sci.

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As wide-spread pollutants in the marine environment, microplastics (MPs) have raised public concern about potential toxic effects in aquatic organisms, and, among others, MPs were suspected to act as a vector for organic pollutants to biota. The purpose of the present study was to investigate effects by three model pollutants, oxybenzone (BP3), benzo[a]pyrene (BaP), and perfluorooctane sulfonate (PFOS) adsorbed to polyethylene MPs on the basis of a standard assay, the acute fish embryo toxicity test (FET; OECD TG 236) with zebrafish (Danio rerio) supplemented by additional endpoints such as induction of ethoxyresorufin-O-deethylase (EROD) activity, modification of cyp1a gene transcription and changes in larval swimming behavior. FET assays were performed in three laboratories using slightly different husbandry and exposure conditions, which, however, were all fully compatible with the limits defined by OECD TG 236. This allowed for testing of potential changes in the FET assay due to protocol variations. The standard endpoints of the FET (acute embryotoxicity) did not reveal any acute toxicity for both virgin MPs and MPs spiked with BP3, BaP, and PFOS. With respect to sublethal endpoints, EROD activity was increased after exposure to MPs spiked with BP3 (3 h pulse) and MPs spiked with BaP (96 h continuous exposure). Cyp1a transcription was increased upon exposure to MPs spiked with BP3 or BaP. For the selected combination of MPs particles and contaminants, the basic FET proved not sensitive enough to reveal effects of (virgin and spiked) MPs. However, given that the FET can easily be supplemented by a broad variety of more subtle and sensitive endpoints, an enhanced FET protocol may provide a relevant approach with developmental stages of a vertebrate animal model, which is not protected by current EU animal welfare legislation (Directive EU 2010/63).

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mentioning

confidence: 99%

Multi-Laboratory Hazard Assessment of Contaminated Microplastic Particles by Means of Enhanced Fish Embryo Test With the Zebrafish (Danio rerio)

Cormier

Batel

Cachot

et al. 2019

Front. Environ. Sci.

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“…Benzophenone and its derivatives are already known to be pharmacologically active and have been demonstrated to bind the pregnane-X receptor. Benzophenone-2 has also been linked to estrogenic activity and developmental effects in zebrafish [92,93]. Most benzophenones indeed show endocrine action at some levels through the estrogen pathway.…”

Section: Uv Filtersmentioning

confidence: 99%

Endocrine Disruption by Mixtures in Topical Consumer Products

Ripamonti¹,

Allifranchini²,

Todeschi³

et al. 2018

Cosmetics

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Endocrine disruption has been gathering increasing attention in the past 25 years as a possible new threat for health and safety. Exposure to endocrine disruptor has been progressively linked with a growing number of increasing disease in the human population. The mechanics through which endocrine disruptors act are not yet completely clear, however a number of pathways have been identified. A key concern is the cumulative and synergic effects that endocrine disruptors could have when mixed in consumer products. We reviewed the available literature to identify known or potential endocrine disruptors, as well as endocrine active substances that could contribute to cumulative effects, in topical consumer products. The number of endocrine actives used daily in consumer products is staggering and even though most if not all are used in concentrations that are considered to be safe, we believe that the possibility of combined effects in mixtures and non-monotonic dose/response is enough to require further precautions. A combined in vitro approach based on existing, validated OECD test methods is suggested to screen consumer products and mixtures for potential interaction with estrogen and androgen hormone receptors, in order to identify products that could have cumulative effects or support their safety concerning direct endocrine disruption capabilities.

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“…Benzophenone passes through the skin and enters the blood stream (89), along with other sunscreen chemicals such as octyl-methoxycinnamate and 3-(4-methylbenzylidene) camphor (90). Benzophenone has been shown to be endocrine disrupting in animals (91, 92), positively associated with women with uterine leiomyomas and endometriosis (93, 94), and increased oxidative stress and genotoxicity (95, 96). Benzophenones are not just limited to sunscreen products.…”

Section: Considerations Of Other Personal Care Productsmentioning

confidence: 99%

Cosmetics use and age at menopause: is there a connection?

Chow

Mahalingaiah

2016

Fertility and Sterility

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Short Narrative Abstract Cosmetics contain a vast number of chemicals, most of which are not under the regulatory purview of the Food and Drug Administration. Only a few of these chemicals have been evaluated for potential deleterious health impact – parabens, phthalates, polycyclic aromatic hydrocarbons, and siloxanes. A review of the ingredients in the best-selling and top rated products of the top beauty brands in the world, as well as a review of highlighted chemicals by non-profit environmental organizations reveal 11 chemicals and chemical families of concern: butylated hydroxyanisole/butylated hydroxytoluene, coal tar dyes, diethanolamine, formaldehyde releasing preservatives, parabens, phthalates, 1,4 dioxane, polycyclic aromatic hydrocarbons, siloxanes, talc/asbestos, and triclosan. Age at menopause can be affected by a variety of mechanisms, including endocrine disruption, failure of DNA repair, oxidative stress, shortened telomere length, and ovarian toxicity. There is a lack of available studies to make a conclusion regarding cosmetics use and age at menopause. What little data there is suggests future studies are warranted. Women with chronic and consistent use of cosmetics across their lifespan may be a population of concern. More research is required to better elucidate the relationship and time windows of vulnerability and the effects of mixtures and combinations of products on ovarian health.

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Endocrine-disrupting effect of the ultraviolet filter benzophenone-3 in zebrafish, Danio rerio

Cited by 88 publications

References 31 publications

Multi-Laboratory Hazard Assessment of Contaminated Microplastic Particles by Means of Enhanced Fish Embryo Test With the Zebrafish (Danio rerio)

Multi-Laboratory Hazard Assessment of Contaminated Microplastic Particles by Means of Enhanced Fish Embryo Test With the Zebrafish (Danio rerio)

Endocrine Disruption by Mixtures in Topical Consumer Products

Cosmetics use and age at menopause: is there a connection?

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