Endocrine disruption and altered biochemical indices in male Oncorhynchus mykiss in response to dimethoate

Assessing the impacts of dimethoate on rotifers′ reproduction through the pre-exposure history

“…Dose-related testicular damage in rats following dimethoate treatment and inhibition of testosterone biosynthesis in interstitial cells of rat exposed to dimethoate (Astiz et al, 2009). A recent study showed that dimethoate did not only reveal an anti-androgenic effect on the fish Oncorhynchus mykiss but also introduced endocrine disrupting action by acting as an estrogen mimic and changing feedback on the hypothalamo-pituitary (H-P) axis (Dogan and Can, 2011). Although dimethoate introduced endocrine disrupting action on above vertebrates, whether dimethoate has the same effect as EDCs on aquatic invertebrates have not been reported before.…”

Insecticides and ovarian functions

“…DMT, a xeno‐estrogen, affects gene expression and cellular functioning by binding to estrogen receptors and thus acts as an endocrine receptor agonist (Akingbemi and Hardy ). By mimicking estrogen action, it also modifies feedback to the hypothalamic–pituitary axis (Dogan and Can ). It inhibits steroidogenesis in both a dose‐ and duration‐dependent manner by decreasing the activity of P450scc enzyme and by blocking the steroidogenic acute regulatory (StAR) gene expression (Walsh et al ).…”

A new method for analysis of the toxicity of organophosphorus pesticide, dimethoate on rotifer based on response surface methodology

“…Previous research showed that 2 mg L −1 dimethoate could significantly reduce the crab Carcinus maenas AChE activity [2]. It also induced oxidative stress, DNA damage and endocrine disruption on the fish Oncorhynchus mykiss [3,4]. For the aquatic invertebrates, the exposure of freshwater snail Lymnaea acuminate to 6.0 mg L −1 of dimethoate resulted in an increase in the total protease activities in hepatopancreas and ovotestis tissue [7].…”

“…Extensive use of dimethoate and the subsequent release into environments may pose a series effect on non-target organisms and alter the balance of biological communities. As a broad used member of the OPs pesticides group, most aquatic toxicity tests of dimethoate have focused on fish [3,4], snail [5][6][7] and crab [2]. Studies on zooplankton are limited [8].…”