Endocrine disruption caused by oral administration of atrazine in European quail (Coturnix coturnix coturnix)

Resino, Irene de la Casa; Valdehíta, Ana; Soler, Francisco; Navas, José M.; Pérez-López, Marcos

doi:10.1016/j.cbpc.2012.07.006

Cited by 32 publications

(20 citation statements)

References 61 publications

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“…Atrazine had been reported to interfere the growth and development of quails, to disturb its reproductive function, to induce endocrine disruption and to trigger the pathological and genotoxic effects [7, 11, 45]. In the present study, nomortality occurred at any dose of ATR administered.…”

Section: Discussionmentioning

confidence: 45%

“…Of note, due to its biological accumulation effect, atrazine do a great harm to the health of organisms and human [5, 6]. Atrazine exposure at environmentally relevant doses or below resulted in endocrine disruptive effects, clear immunomodulatory, genotoxic action, metabolic disorders, neurodegenerative disorders, and so on [7-11]. Recent results from our laboratories clearly demonstrated that atrazine-induced developmental abnormality of ovary and oviduct is associated with disruption of gonadal hormone balance and hypothalamo-pituitary-ovarian axis in quails [12].…”

Section: Introductionmentioning

confidence: 99%

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A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases

Lin

Qin

et al. 2016

Oncotarget

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The widely used atrazine has been reported to exhibit extensive ecological hazards. Due to the biological accumulation, atrazine elicits widespread toxic effects on different organisms. However, true proof for the mechanism of atrazine-induced toxicity is lacking. To determine the potential mechanism by which atrazine exerted toxic effects, quails were treated with atrazine (0, 50, 250 and 500 mg/kg) by gavage administration for 45 days. Atrazine significantly increased the histological alterations and serum creatine kinase, lactate dehydrogenase and choline esterase levels. A marked disorder in ionic (Na+, K+, Ca2+ and Mg2+)contents and the decrease of ATPases (Na+-K+-ATPase, Ca2+-ATPase, Mg2+-ATPase and Ca2+-Mg2+-ATPase) activities were observed in the heart and liver of atrazine-exposed quails. Of note, it was also observed that atrazine suppressed the transcription of Na+, K+ transfer associated genes (Na+-K+-ATPase subunits) and Ca2+ transfer associated genes (Ca2+-ATPase subunits, solute carriers) in heart and liver. In conclusion, atrazine induced cardiac and hepatic damage via causing the ionic disorder, triggering the transcription of the ion transporters and leading the histopathological and functional alternations in the heart and liver of quails. This study demonstrated atrazine significantly induced the ionic disorder via decreasing the ATPases activities and disturbing the transcription of the ion transporters.

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Section: Discussionmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 99%

A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases

Lin

Qin

et al. 2016

Oncotarget

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“…The environmental levels of AZ up to 108 μg/L have been reported in rivers of North America . The compound can induce reproductive toxicity in many species of animals, such as fish, amphibians, reptiles, birds, and mammals …”

Section: Introductionmentioning

confidence: 99%

Analysis of long non‐coding RNA involved in atrazine‐induced testicular degeneration of Xenopus laevis

Sai¹,

Qu²,

Zhang³

et al. 2019

Environmental Toxicology

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Long non-coding RNA (lncRNA) plays a critical role in male germline development. Atrazine (AZ) as an environmental endocrine disrupting chemical (EDCs) can induce male reproductive toxicity in amphibians. Our previous studies demonstrated that AZ can alter gene and circular RNA (cir-cRNA) expression of damaged testes in Xenopus laevis (X. laevis). We furthered to investigate the lncRNA expression profiling in the testis of X. laevis. Over 3559 lncRNAs were detected by lncRNA sequencing. AZ induced 40 upregulated and 46 downregulated differentially expressed lncRNAs. KEGG analysis showed that AZ-affected lncRNAs mainly involve in 19 pathways among which 12 pathways are found in circRNA analysis. This study for the first time demonstrated that AZ can alter lncRNAs which may play a role in testicular degeneration through regulating expressions of functional genes in X. laevis. Our data may provide more insights on the mechanism about male reproductive toxicity of EDCs. K E Y W O R D S ceRNA, frog, herbicide, lncRNA, reproductive toxicology

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“…According to the risk assessment report of US Environmental Protection Agency (EPA), atrazine could have some harmful impact on fish, terrestrial, and aquatic plants, and it might also adversely affect reptiles and amphibians [12]. Atrazine has a significantly toxic effect on animals, and the lethal dose (LD50) for rat and quail is 672 and 5000 mg/kg, respectively [13,14]. Xing et al [15] found that atrazine induced the methylation of DNA in carp brain and caused the autophagy in the liver.…”

Section: Introductionmentioning

confidence: 99%

A Review on Recent Treatment Technology for Herbicide Atrazine in Contaminated Environment

Liu

You

et al. 2019

IJERPH

118

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Atrazine is a kind of triazine herbicide that is widely used for weed control due to its good weeding effect and low price. The study of atrazine removal from the environment is of great significance due to the stable structure, difficult degradation, long residence time in environment, and toxicity on the organism and human beings. Therefore, a number of processing technologies are developed and widely employed for atrazine degradation, such as adsorption, photochemical catalysis, biodegradation, etc. In this article, with our previous research work, the progresses of researches about the treatment technology of atrazine are systematically reviewed, which includes the four main aspects of physicochemical, chemical, biological, and material-microbial-integrated aspects. The advantages and disadvantages of various methods are summarized and the degradation mechanisms are also evaluated. Specially, recent advanced technologies, both plant-microbial remediation and the material-microbial-integrated method, have been highlighted on atrazine degradation. Among them, the plant-microbial remediation is based on the combined system of soil-plant-microbes, and the material-microbial-integrated method is based on the synergistic effect of materials and microorganisms. Additionally, future research needs to focus on the excellent removal effect and low environmental impact of functional materials, and the coordination processing of two or more technologies for atrazine removal is also highlighted.

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Endocrine disruption caused by oral administration of atrazine in European quail (Coturnix coturnix coturnix)

Cited by 32 publications

References 61 publications

A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases

A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases

Analysis of long non‐coding RNA involved in atrazine‐induced testicular degeneration of Xenopus laevis

A Review on Recent Treatment Technology for Herbicide Atrazine in Contaminated Environment

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