Endocrine disruption induced by bisphenol A in young and adult female Sprague Dawley rats

Hamdy, Hanaa; Yahia, Doha; Afifi, S. H.; Salem, Diefy

doi:10.1007/s00580-018-2689-2

Cited by 4 publications

(1 citation statement)

References 48 publications

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“…They are extensively used in diverse products of daily life, including electronic and medical equipment, reusable bottles and water pipes. In addition, epoxy resins are used in the coating of the inner surfaces of food and beverage containers to prevent the reactions of the contents with metals (16,19,38).…”

Section: Praca Oryginalna Original Papermentioning

confidence: 99%

Influence of bisphenol A on spermatological parameters of New Zealand White Rabbits

Karabulut¹,

Gülay²

2020

Medycyna Weterynaryjna

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This study aimed to investigate the possible reproductive toxicity dose of bisphenol A (BPA) in male New Zealand white rabbits. Prior to the experiment, male rabbits (n = 24) were acclimatized to laboratory conditions and trained for semen collection for 14 days. After the training period, rabbits were divided into 4 groups of 6: positive controls and 3 different doses of BPA (10, 20 and 100 mg/kg/day). All treatments were administered by oral gavages for 9 weeks following the training period. At the end of the study, BPA negatively affected the serum testosterone, testicular superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and malondialdehyde (MDA). Sperm concentrations and percent progressive motility were significantly declined in BPA treated rabbits. LOAEL value of BPA for reproductive parameters was 10 mg/kg/day.

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Section: Praca Oryginalna Original Papermentioning

confidence: 99%

Influence of bisphenol A on spermatological parameters of New Zealand White Rabbits

Karabulut¹,

Gülay²

2020

Medycyna Weterynaryjna

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Quantification of Bisphenol A in Swiss albino mice following topical exposure

Singh

Thakur

Shukla

et al. 2023

Journal of Hazardous Materials Advances

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Dose exposure of Bisphenol- A on female Wistar rats fertility

Srivastava

Dhagga

2019

Hormone Molecular Biology and Clinical Investigation

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Background 2, 2-Bis (4-hydroxyphenyl propane [bisphenol A (BPA)] is one of the major environmental pollutants and has the adverse effects on human health. BPA mimics the structure of estrogen and binds to estrogen receptors and alters the secretion of the hormone. It is ingested in humans through the regular use of plastic containers, bottles and food cans. Materials and methods Female Wistar rats were exposed orally to 5, 50, 300, 600 and 800 mg BPA/kg body weight (bd. wt.)/week mixed in olive oil and administered every 168 h for 3 months continuing through the mating, gestation and lactation and its effects on fertility, reproductive organ weight and hormones [LH (luteinizing hormone), FSH (follicle stimulating hormone), estradiol (E2), progesterone (PROG) and PRL (prolactin)] were evaluated. Results The findings revealed that females exposed to BPA exhibited a decrease in female fertility rate and weight of reproductive organs (ovary and uterus) with significant decreased levels of LH, FSH, E2, PROG and PRL in the non-pregnancy phase whereas in cesarean and post-term females, no significance difference was found in fertility rate, reproductive organ weight and hormonal levels. Conclusions These data indicate an increased sensitivity to BPA needs careful evaluation of the current levels of exposure.

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Endocrine disruption induced by bisphenol A in young and adult female Sprague Dawley rats

Cited by 4 publications

References 48 publications

Influence of bisphenol A on spermatological parameters of New Zealand White Rabbits

Influence of bisphenol A on spermatological parameters of New Zealand White Rabbits

Quantification of Bisphenol A in Swiss albino mice following topical exposure

Dose exposure of Bisphenol- A on female Wistar rats fertility

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