Endocrine disruptors and childhood social impairment

Miodovnik, Amir; Engel, Stephanie M.; Zhu, Chenbo; Ye, Xiaoyun; Soorya, Latha; Silva, Manori J.; Calafat, Antònia M.; Wolff, Mary S.

doi:10.1016/j.neuro.2010.12.009

Cited by 369 publications

(287 citation statements)

References 66 publications

Supporting

Mentioning

263

Contrasting

Unclassified

Order By: Relevance

“…41 A recent epidemiological study suggests that gestational BPA exposure may be associated with impaired social behaviors in children. 42 However, the authors did not find that their associations were modified by child gender.…”

Section: Discussionmentioning

confidence: 90%

“…52 Instead, we focused on the patterns, magnitudes, and consistency of our results and compared those factors with findings from our previous studies and experimental studies with animals. 38,42 The clinical relevance of these findings is unclear at this point. Despite this uncertainty, clinicians can advise concerned patients to reduce their exposure, as well as cautioning that it is difficult to avoid all sources of exposure and the health consequences of BPA exposure are not fully understood.…”

Section: Figurementioning

confidence: 97%

See 1 more Smart Citation

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

et al. 2011

Self Cite

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT:Virtually all persons in industrialized countries are exposed to bisphenol A (BPA), and early-life BPA exposure might be associated with behavior problems. Few human studies have been conducted, and the impact of gestational versus childhood BPA exposures is unclear. WHAT THIS STUDY ADDS:BPA exposure during pregnancy, but not childhood, was associated with worse behavior at 3 years of age, especially among girls. Domains related to behavioral and emotional regulation were most affected by gestational BPA exposure. abstract OBJECTIVES:To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations. METHODS:We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respectively. Behavior and executive function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). RESULTS:BPA was detected in Ͼ97% of the gestational (median: 2.0 g/L) and childhood (median: 4.1 g/L) urine samples. With adjustment for confounders, each 10-fold increase in gestational BPA concentrations was associated with more anxious and depressed behavior on the BASC-2 and poorer emotional control and inhibition on the BRIEF-P. The magnitude of the gestational BPA associations differed according to child gender; BASC-2 and BRIEF-P scores increased 9 to 12 points among girls, but changes were null or negative among boys. Associations between childhood BPA exposure and neurobehavior were largely null and not modified by child gender. CONCLUSIONS:In this study, gestational BPA exposure affected behavioral and emotional regulation domains at 3 years of age, especially among girls. Clinicians may advise concerned patients to reduce their exposure to certain consumer products, but the benefits of such reductions are unclear. Pediatrics 2011;128:873-882 AUTHORS:

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Figurementioning

confidence: 97%

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…7,19 Apesar disso, os efeitos sobre a saúde humana associados aos interferentes endócrinos ainda não são definitivamente comprovados. Porém, outras evidências sugerem que a antecipação na idade da menarca, 128 137 podem estar associadas à exposição de seres humanos em desenvolvimento frente a esses compostos. Outro trabalho discute ainda o mecanismo de transporte de compostos interferentes endócrinos, como o bisfenol A, pela placenta e aponta efeitos negativos no desenvolvimento neurológico dos bebês.…”

Section: Efeitos Relacionados à Presença De Compostos Interferentes Eunclassified

Contaminantes emergentes em matrizes aquáticas do Brasil: cenário atual e aspectos analíticos, ecotoxicológicos e regulatórios

2017

View full text Add to dashboard Cite

publicado na web em 11/07/2017 EMERGING CONTAMINANTS IN AQUATIC MATRICES FROM BRAZIL: CURRENT SCENARIO AND ANALYTICAL, ECOTOXICOLOGICAL AND LEGISLATIONAL ASPECTS. Emerging contaminants occur in parts per trillion or less in aquatic matrices. The effects related to the exposure of aquatic biota and human to them have been identified for different compounds. The knowledge about the concentrations of the exposure is the first step to perform risk assessments. The present work describes a literature review about occurrence in Brazilian aquatic matrices, and a discussion about biological effects, legislation and analytical aspects involving the presence of emerging compounds. The review includes 58 papers published between 1997 and 2016, considering the occurrence of personal care and pharmaceutical compounds, illicit drugs, hormones, pesticides and some other endocrine disruptors compounds in the matrices sewage, surface, ground and drinking waters. The concentrations varied from ng L -1 to μg L -1 , depending on the region and the compound. However, the contamination scenario was aggravated by the combination of poor sanitation status -such as low investment in sewage treatment plants, which led to an expressive contamination of the receiving waters with sewage -and the current goods consumption level, which is similar to that of developed countries. These data provide a good insight into the particular levels of contamination and can be used both for further researches and decision making in the regulation area of public policy.Keywords: emerging contaminants; endocrine disruptors compounds; drinking water; surface water; wastewater. CONTAMINANTES EMERGENTESA temática dos contaminantes emergentes ganhou destaque na década passada e vem sendo abordada em diferentes aspectos por pesquisadores do mundo todo. Tratam-se de centenas de compostos que têm sido detectados nos diferentes compartimentos ambientais (solo, água e ar), sendo eles tanto de origem antrópica (presentes em efluentes domésticos, industriais, hospitalares e aqueles provenientes das atividades agrícola e pecuária), quanto de ocorrência natural (presentes em diferentes espécies de plantas, por exemplo). Estes compostos podem apresentar algum risco ao ecossistema e eles não estão incluídos nos programas de monitoramento de rotina, ou seja, não são legislados. Assim, serão candidatos a uma futura regulamentação dependendo dos resultados obtidos em estudos de ecotoxicidade, efeitos à saúde humana, potencial de bioacumulação, transporte e destino nos diferentes compartimentos ambientais, além da quantidade em que são lançados e, portanto, da concentração no ambiente. Tratam-se de estudos que envolvem diferentes áreas da ciência e que têm sido considerados fundamentais para o esclarecimento dos novos paradigmas relacionados ao estilo de vida moderno. Conhecer os riscos associados à exposição por centenas de novos compostos que ainda não estão contemplados nas legislações vigentes permite antecipar e mitigar sérios danos para as gerações futuras.Muitos dos e...

show abstract

“…Exposure to phthalates have been examined in relation to neurodevelopment among neonates 5 days of birth [5], and 5 weeks [6] in the United States, in Korea in children at 6 months and children from elementary schools [7,8], in the United States among children 4-9 years [9] and 3.6-6.4 years of age [10]. One study (also conducted in the United States) has assessed social impairment in children 7 and 9 years old exposed to phthalates [11] ( Table 1). …”

Section: Ijomeh 2013;26(2) 187mentioning

confidence: 99%

“…Five studies have examined the association between BPA exposure and neurodevelopment: four in children [11,[13][14][15] and one among infants [6] ( Table 2). In the study in Cincinnati, Ohio (USA) no association between mean urinary BPA concentrations and behaviour scores among children, at 2 years of age, was found.…”

Section: Ijomeh 2013;26(2) 187mentioning

confidence: 99%

Exposure to widespread environmental toxicants and children’s cognitive development and behavioral problems

Jurewicz¹,

Polańska²,

Hanke³

2013

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Nowadays a special attention is focused on prenatal and childhood exposures to a variety of contaminants in the environment, especially toxicants widely present in the environment and their impact on children's health and neurodevelopment. This article aims at evaluating the impact of exposure to several widespread toxicants including: polycyclic aromatic hydrocarbons (PAHs), phthalates, bisphenol A, brominated flame retardants and gas cooking on children's cognitive development and behavioral problems by reviewing most recent published literature. Epidemiological studies focusing on exposure to widespread toxicants and children's development for the last eleven years were identified by a search of the PubMed, Medline, Ebsco and Toxnet literature bases. The combination of following key words was used: 1) referring to the exposure: pregnancy, prenatal exposure, postnatal exposure, gas cooking, exposure to phthalates, bisphenol A, brominated flame retardants, PAHs and 2) referring to outcome: neurodevelopment, neurobehavior, psychomotor development, behavioral problems, cognitive development, mental health, school achievements, learning abilities. The results from the presented studies suggest that there are strong and rather consistent indications that the developing nervous system is particularly vulnerable to insult from low levels of exposure to widespread environmental contaminants such as: phthalates, bisphenol A, brominated flame retardants, polycyclic aromatic hydrocarbons, gas cooking. Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented.

show abstract

Endocrine disruptors and childhood social impairment

Cited by 369 publications

References 66 publications

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

Contaminantes emergentes em matrizes aquáticas do Brasil: cenário atual e aspectos analíticos, ecotoxicológicos e regulatórios

Exposure to widespread environmental toxicants and children’s cognitive development and behavioral problems

Contact Info

Product

Resources

About