Endocrine, neural and pharmacological aspects of sexual satiety in male rats

Phillips-Farfán, Bryan V.; Fernández‐Guasti, Alonso

doi:10.1016/j.neubiorev.2008.11.003

Cited by 55 publications

(31 citation statements)

References 160 publications

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“…As with food intake, the control of the multiple aspects of sexual behavior relies on a complex neurocircuitry, where the components of the opioid system are well represented (73, 135, 166, 248, 295, 387). Opioids are commonly described as exerting an inhibitory influence on male and female sexual activity.…”

Section: Local Pharmacological Manipulation Of the Opioid Systemmentioning

confidence: 99%

“…In the anterior region of the hypothalamus, the sexual dimorphic medial preoptic area (MPOA) has received much attention as a critical brain substrate for the control of sexual behavior (23, 104, 166, 295, 387), where opioids can exert their modulatory effects (9, 166, 387). Briefly, opioid receptor agonists injected directly into the MPOA inhibited or delayed masculine copulatory activity in rats, except for low doses of morphine or dynorphin-A-(1—13) (reviewed in Ref.…”

Section: Local Pharmacological Manipulation Of the Opioid Systemmentioning

confidence: 99%

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Reward Processing by the Opioid System in the Brain

Merrer¹,

Becker²,

Befort³

et al. 2009

Physiological Reviews

853

676

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The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin. Opioid receptors are recruited in response to natural rewarding stimuli and drugs of abuse, and both endogenous opioids and their receptors are modified as addiction develops. Mechanisms whereby aberrant activation and modifications of the opioid system contribute to drug craving and relapse remain to be clarified. This review summarizes our present knowledge on brain sites where the endogenous opioid system controls hedonic responses and is modified in response to drugs of abuse in the rodent brain. We review 1) the latest data on the anatomy of the opioid system, 2) the consequences of local intracerebral pharmacological manipulation of the opioid system on reinforced behaviors, 3) the consequences of gene knockout on reinforced behaviors and drug dependence, and 4) the consequences of chronic exposure to drugs of abuse on expression levels of opioid system genes. Future studies will establish key molecular actors of the system and neural sites where opioid peptides and receptors contribute to the onset of addictive disorders. Combined with data from human and nonhuman primate (not reviewed here), research in this extremely active field has implications both for our understanding of the biology of addiction and for therapeutic interventions to treat the disorder.

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Section: Local Pharmacological Manipulation Of the Opioid Systemmentioning

confidence: 99%

Section: Local Pharmacological Manipulation Of the Opioid Systemmentioning

confidence: 99%

Reward Processing by the Opioid System in the Brain

Merrer¹,

Becker²,

Befort³

et al. 2009

Physiological Reviews

853

676

View full text Add to dashboard Cite

show abstract

“…Although multi-day cycles in female rat hormonal levels that correspond with changes in sexual behavior are well documented [1-5], to our knowledge no one has previously described male hormonal levels and sexual behavior across consecutive days. Past experiments documenting the sexual behavior and hormonal levels of male rats have focused mainly on males that reach sexual exhaustion during one prolonged interaction with one or more females [6-9]. A few studies have shown differences in sperm count and amount of ejaculate in a number of species across a period of days or weeks, often corresponding with the length of the female estrous cycle but have not investigated the possibility of cycles in male sexual behavior [10-12].…”

Section: Introductionmentioning

confidence: 99%

“…Sexual performance is not completely recovered until 15 days after the onset of sexual exhaustion. For most males, partial recovery begins 72 h following the onset of sexual exhaustion [6, 9], and some males will copulate within 24 h after exhaustion but these males do not achieve more than one ejaculation [8]. Sexual exhaustion is believed to be induced by high circulating levels of prolactin following multiple ejaculations [9].…”

Section: Introductionmentioning

confidence: 99%

Changes in the sexual behavior and testosterone levels of male rats in response to daily interactions with estrus females

Shulman

Spritzer

2014

Physiology & Behavior

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Male rat sexual behavior has been intensively studied over the past 100 years, but few studies have examined how sexual behavior changes over the course of several days of interactions. In this experiment, adult male rats (n = 12) were given daily access to estrus females for 30 min per day for 15 consecutive days and control males did not interact with females. Ovariectomized females were induced into estrus with hormonal injections, and males interacted with a different female each day. The amount of sexual activity (mounts, intromissions, and ejaculations) was found to cycle with a period of approximately 4 days in most male rats. Additionally, blood was collected every other day following sexual interactions to assess serum testosterone levels. Testosterone was found to peak on the first day of interaction and then fell back to near the level of control rats that did not interact with females. Following the initial peak, testosterone concentrations fluctuated less in males exposed to females than in controls. Sexual activity was not found to predict testosterone concentration. We conclude that when male rats have daily sexual interactions, sexual behavior tends to show cyclic changes and testosterone is significantly elevated only on the first day of interactions.

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“…In contrast to females, for which mating induces drastic behavioural and physiological changes (Gillott, 2003;Serguera et al, 2008;Yang et al, 2009), males can often re-mate after a variable time delay. Although males of many species are known to enter a postejaculatory refractory period (Bateman and Ferguson, 2004;Fischer and King, 2008;Lachmann, 2000;Phillips-Farfán and Fernández-Guasti, 2009;Reddy and Guerrero, 2000;Soulairac, 1952;Ureshi and Sakai, 2001), the mechanisms that lead to this sexual satiety are far from being understood in any organism.…”

Section: Introductionmentioning

confidence: 99%

Switching attraction to inhibition: mating-induced reversed role of sex pheromone in an insect

Barrozo¹,

Gadenne²,

Anton³

2010

Journal of Experimental Biology

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SUMMARYIn the moth, Agrotis ipsilon, newly mated males cease to be attracted to the female-produced sex pheromone, preventing them from re-mating until the next night, by which time they would have refilled their reproductive glands for a potential new ejaculate. The behavioural plasticity is accompanied by a decrease in neuron sensitivity within the primary olfactory centre, the antennal lobe (AL). However, it was not clear whether the lack of the sexually guided behaviour results from the absence of sex pheromone detection in the ALs, or if they ignore it in spite of detection, or if the sex pheromone itself inhibits attraction behaviour after mating. To test these hypotheses, we performed behavioural tests and intracellular recordings of AL neurons to non-pheromonal odours (flower volatiles), different doses of sex pheromone and their mixtures in virgin and newly mated males. Our results show that, although the behavioural and AL neuron responses to flower volatiles alone were similar between virgin and mated males, the behavioural response of mated males to flower odours was inhibited by adding pheromone doses above the detection threshold of central neurons. Moreover, we show that the sex pheromone becomes inhibitory by differential central processing: below a specific threshold, it is not detected within the AL; above this threshold, it becomes inhibitory, preventing newly mated males from responding even to plant odours. Mated male moths have thus evolved a strategy based on transient odour-selective central processing, which allows them to avoid the risk-taking, energy-consuming search for females and delay re-mating until the next night for a potential new ejaculate.

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Endocrine, neural and pharmacological aspects of sexual satiety in male rats

Cited by 55 publications

References 160 publications

Reward Processing by the Opioid System in the Brain

Reward Processing by the Opioid System in the Brain

Changes in the sexual behavior and testosterone levels of male rats in response to daily interactions with estrus females

Switching attraction to inhibition: mating-induced reversed role of sex pheromone in an insect

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