Endocrine Regulation of the Mucosal Immune System in the Female Reproductive Tract

Wira, Charles R.; Rodriguez-García, Marta; Patel, Mickey V.; Biswas, Nabanita; Fahey, John V.

doi:10.1016/b978-0-12-415847-4.00110-5

Cited by 12 publications

(12 citation statements)

References 112 publications

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“…Some neutrophilic granulocytes were at the same time in a state of apoptosis . This confirms that neutrophil phagocytes provide support for immune homeostasis (Wira et al, 2015;.…”

Section: Resultssupporting

confidence: 62%

“…Recently, scientists from different countries of the world are increasingly attracted by the role of immune cells in the formation of immune homeostasis in the body of animals (Hagman et al, 2009;Sheldon et al, 2010;Voorward et al, 2015). After all, Immune responses are important at all stages of the formation of the reproductive system of animals and have a regulating effect in different periods of their reproductive ability (Silva et al, 2012;Amos et al, 2014;Wira et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Study of innate factors in the local immune defense of the genital organs of dogs and cats

Zhelavskyi

2019

SMLNUVMB

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Zhelavskyi, M.M. (2019). Study of innate factors in the local immune defense of the genital organs of dogs and cats. Scientific Messenger of Lviv National University of Veterinary Medicine and Biotechnologies. Series: Veterinary sciences, 21(93), 98-102. doi: 10.32718/nvlvet9317Immune system of reproductive organs of animals is represented by a number of cellular and humoral protection factors. Recently, the attention of scientists was attracted by the role of immunocompetent cells, which integrally provide immune homeostasis at all stages of the reproductive function. The purpose of the work was to study the cellular factors of immune defense of mucous membranes of genital organs of dogs and cats. The cytological composition and determination of immunological parameters of vaginal microscope slide were determined by patented methods. Local immunity was determined by the parameters of extracellular protection mechanisms, which consisted in the study of the Oxygen-dependent potential of neutrophil granulocytes (NBT-test) and their ability to form extracellular traps (NETs). Our studies have found that in different stages of the sexual cycle in beach and cats, along with cytological changes in epithelial cells, changes occur in phagocytic protection. In particular, in the post-infusion period there was an increase in the number of intermediate and basal epithelial cells on the surface of which were adhered microorganisms. Along with epithelial cells, activated phagocytes were grouped. Neutrophils showed cytochemical reactivity in the NBT-test, and also formed NETs. At the same time, activated phagocytes absorbed microorganisms, and some epithelial cells formed specific cytoplasmic inclusions, which obviously also has an important role in the antimicrobial immunity of the mucosa. Some neutrophilic granulocytes were in a state of apoptosis. During the sexual cycle in the organism of dogs and cats there are morphology and functional changes in the genital organs, which was accompanied by a change in the cytological picture of vaginal microscope slides. It was established that the antimicrobial protection system plays an important role in the neutrophilic granulocytes, the functional activity of which also has a change. The main mechanisms of extracellular antimicrobial protection of microphages are realized with the involvement of Oxygen species in the excretion system of active forms and the formation of neutrophilic extracellular traps. Epithelial cells are also involved in the formation of immune homeostasis of genital mucous membranes.

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“…Some neutrophilic granulocytes were at the same time in a state of apoptosis . This confirms that neutrophil phagocytes provide support for immune homeostasis (Wira et al, 2015;.…”

Section: Resultssupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Study of innate factors in the local immune defense of the genital organs of dogs and cats

Zhelavskyi

2019

SMLNUVMB

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“…In contrast to external secretions of lacrimal, salivary, and lactating mammary glands and the gastrointestinal tract, in which secretory immunoglobulin A (S-IgA) represents the dominant Ig isotype, both male and female human genital tract secretions contain slightly more immunoglobulin G (IgG) than IgA (Kutteh et al 1996;Baker et al 2015) (Table 1.2). Furthermore, in females the levels and Ig distribution display marked hormonally dependent differences during the menstrual cycle (Hocini and Barra 1995;Kutteh et al 1996;Rodgriques Garcia et al 2015;Crowley-Nowick et al 1997a;Wira et al 2005Wira et al , 2015. Consequently, evaluation of humoral immune responses should take into the account the timing of collection of such fluids to provide comparable results (Mestecky et al 2011).…”

Section: Immunoglobulins In Secretions Of the Genital Tractmentioning

confidence: 99%

Chlamydia Trachomatis Urogenital Infections

Armitage

Carey

Hickey

et al. 2018

Diagnostics to Pathogenomics of Sexually Transmitted Infections

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Quantitative evaluation of the cells involved in the immune system, such as lymphocytes, plasma cells, macrophages, dendritic cells, and epithelial cells, together with their products, including antibodies, cytokines, and humoral factors of innate immunity, convincingly revealed that the immune system associated with the mucosae is greater than its systemic counterpart (Russell et al. 2015a). This fact should not be surprising, as the development of the entire immune system during evolution and continuously in everyday life is driven by stimulation with commensal microbiota, antigens present in food and inhaled air, as well as pathogens throughout the enormous surface area of mucosal sites, which far exceeds the skin surface. The mucosal immune system comprises anatomically remote and physiologically distinct compartments that provide protection at various mucosal sites. Although the genital tract shares some common features with other mucosae, including the presence of humoral factors and cells of innate immunity, and the origin of cells involved in antibody production and T cell-mediated immunity, there are also many distinct features characteristic of the genital tract (Russell and Mestecky 2002, 2010; Mestecky et al. 2005). The spectrum of antigens including commensal or pathogenic microorganisms, and sperm is different from those at other mucosal sites. Furthermore, the primary physiological role of the genital tract is reproduction, which involves the acceptance of allogeneic sperm and semi-allogeneic offspring. This distinct physiological role influences the immune system of the genital tract with respect to the induction or suppression of immune responses, which must be considered in the development and application of vaccines against infectious agents of sexually transmitted diseases.

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“…7 Furthermore, these hormones also have a significant role in regulating immune cells and mediators throughout the reproductive tract. 8,9 These features will be discussed in more detail below.…”

Section: Female Reproductive Tract Structure and Morphologymentioning

confidence: 99%

“…7,8 Before HIV-1 can establish a productive infection in the FRT, it must overcome a number of mechanical, chemical and biological barriers. The mucus, AMP and Type 1 IFNs secreted by the epithelial and innate immune cells significantly impede the ability of HIV to establish infection in the FRT.…”

Section: 4mentioning

confidence: 99%

Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection

et al. 2014

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The male and female reproductive tracts are complex microenvironments that have diverse functional demands. The immune system in the reproductive tract has the demanding task of providing a protective environment for a fetal allograft while simultaneously conferring protection against potential pathogens. As such, it has evolved a unique set of adaptations, primarily under the influence of sex hormones, which make it distinct from other mucosal sites. Here, we discuss the various components of the immune system that are present in both the male and female reproductive tracts, including innate soluble factors and cells and humoral and cell-mediated adaptive immunity under homeostatic conditions. We review the evidence showing unique phenotypic and functional characteristics of immune cells and responses in the male and female reproductive tracts that exhibit compartmentalization from systemic immunity and discuss how these features are influenced by sex hormones. We also examine the interactions among the reproductive tract, sex hormones and immune responses following HIV-1 infection. An improved understanding of the unique characteristics of the male and female reproductive tracts will provide insights into improving clinical treatments of the immunological causes of infertility and the design of prophylactic interventions for the prevention of sexually transmitted infections.

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Endocrine Regulation of the Mucosal Immune System in the Female Reproductive Tract

Cited by 12 publications

References 112 publications

Study of innate factors in the local immune defense of the genital organs of dogs and cats

Study of innate factors in the local immune defense of the genital organs of dogs and cats

Chlamydia Trachomatis Urogenital Infections

Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection

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