Endocrine Studies in a Patient with a Gonadotropin-Secreting Bronchogenic Carcinoma

Para-Endocrine Tumor Activity with Emphasis on Ectopic ADH Secretion

“…Faster progress in this field requires development of appropriate animal tumor models, allowing establishment of multiple, uniform investigative conditions, with regard to time of appearance of para-endocrine activity in relation to genetic and malignant changes and tumor growth; animal tumor models may also serve as a means for screening of various treatment modalities (surgery, radiotherapy, chemotherapy, immunotherapy) under controlled conditions. Diagnostic and therapeutic means such as intracellular localization of gonadotropins by immuno fluorescence [8,23] or even administration of gonadotropin antiserum or other antisera directed against respective para-endocrine tumor activity may prove to be useful diagnostic and therapeutic procedures not only in such animal tumors, but also in hormonally active human cancers. Also anahormones -chemically modified hormones which have lost their hormonal activity while they have retained their antigenic specificity and binding affinity to respective hormonal target cells -may be investigated in regard to their possible placement in para-endocrine tumor diagnostic and treatment [39], Anahormones are prepared from respective normal hormones (HGH, ACTH, insulin, gonadotropins) by iodination, acetylation, and oxidation [59] and they can compete with the respective native hormone.…”

Ectopic Production of Human Chorionic Gonadotrophin by Human Breast Tumours

“…They also showed the presence of gonadotrophins in the tumour tissue. Since then a number of observations on gonadotrophin production in men having bronchogenic carcinoma have been reported (Faiman et al, 1967;Becker et al, 1968;Rosen et al, 1968). Similar studies on ectopic production of gonadotrophins by hepatoma (Reeves, Tesluk and Harrison, 1959), hepatoblastoma (Root, Bogiovanni and Eberlein, 1968), adrenocortical carcinoma (Rose et al, 1968), and carcinoma of the breast (McArthur, 1963) Greenwood, Hunter and Glover (1963) as modified by Midgley (1966) was used to iodinate the : subunit of HCG.…”

Metastatic Bronchogenic Carcinoma with Human Chorionic Gonadotropin Production Manifesting as Cerebellar Hemorrhage. Case Report.

“…1,3,7,20) Previous immunohistochemical studies on hCG/hCGb-producing bronchogenic carcinomas demonstrated that localization of immunoreactive hCG/hCGb was usually associated with syncytiotrophoblastic giant cells scattered among the non-trophoblastic carcinoma cells. This finding may indicate that the non-trophoblastic carcinoma retrodifferentiated to choriocarcinoma.…”