Endocrinology of pregnancy in the dog: A review

Verstegen-Onclin, K.; Verstegen, J.

doi:10.1016/j.theriogenology.2008.04.038

Cited by 76 publications

(56 citation statements)

References 53 publications

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“…The failure of a single fetus to induce parturition mechanism after or before the expected date of gestation owing to its reduced concentration of cortisol secreted. It has been hypothesized that it is insufficient to initiate luteolysis via prostaglandinglucocorticoid pathway (Verstegen-Onclin and Vertegen, 2008). Insensitiveness of the myometrium to medical management in the present report was inability to initiate segmental contractility owing to the presence of foetus at ovarian end.…”

Section: Resultsmentioning

confidence: 49%

A rare case of single pup syndrome and its management in a Labrador bitch

Ganesan¹,

Sankar²,

Ninu³

et al. 2016

IJAR

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The intricate way of parturition in bitches is initiated by luteolysis in response to cortisol released by the fetuses in utero. Failure of luteolysis always associated with small litters and often leads to dystocia. The present case report documents an unusual case of single pup syndrome in a two year old Labrador bitch carrying single fetus. This syndrome has occurred at its first whelping wherein the dog made futile attempts to deliver the fetus, which has eventually become unproductive. Hence, caesarean section was indicated to save the life of the fetus and to preserve the welfare of the dam.

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Section: Resultsmentioning

confidence: 49%

A rare case of single pup syndrome and its management in a Labrador bitch

Ganesan¹,

Sankar²,

Ninu³

et al. 2016

IJAR

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show abstract

“…Pregnancy is associated with IR in humans and dogs, which occurs in response to suppression of the intracellular transport of glucose and its increasing concentration in blood. P 4 , estradiol, growth hormone, placental lactogen and placental cytokines all play important roles in causing insulin resistance [10,17]. There are several causes of resistance to exogenous insulin that do not lead to IR, such as improper handling and administration of insulin.…”

Section: Discussionmentioning

confidence: 99%

Use of aglepristone for the treatment of P₄induced insulin resistance in dogs

et al. 2014

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Insulin resistance (IR) in dogs is suspected when hyperglycemia is present despite administration of insulin doses greater than 1.0 to 1.5 UI/kg. IR is caused by increases in counter regulatory hormones concentrations (glucagon, glucocorticoids, catecholamines and growth hormone). This study was conducted to investigate the use of aglepristone (RU 46534), a P4 receptor antagonist, for the treatment of IR diabetes mellitus in bitches during the luteal phase. All animals were treated with porcine insulin zinc suspension (Caninsulin) and aglepristone (Alizin) 10 mg/kg subcutaneously at day 1, 2, 9 and 17 from diagnosis. At day 5, no significant variation in glycemia was shown. At day 12 and 20, serum glucose concentrations were significant lower (p < 0.05). From day 12 the insulin dose was reduced to 0.8 IU BID. Insulin was reduced in the following weeks and glycemia was controlled.

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“…Since the CL of pregnancy and pseudopregnancy have similar lifespans, a pregnancy recognition signal does not seem to be required for CL maintenance during pregnancy. A comprehensive review of the endocrinology of pregnancy in the bitch indicates that much is yet to be learned about reproduction in dogs (Verstegen-Onclin and Verstegen 2008 ). Current knowledge of pregnancy in the dogs is presented in Chap 11 .…”

Section: Pregnancymentioning

confidence: 99%

History of Maternal Recognition of Pregnancy

Bazer

2015

Regulation of Implantation and Establishment of Pregnancy in Mammals

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The mechanism for signaling pregnancy recognition is highly variable among species, and the signaling molecule itself varies between estrogens in pigs to chorionic gonadotrophin in primates. This chapter provides insight into the menstrual cycle of women and estrous cycles of rodents, dog, cat, pigs, sheep, rabbits, and marsupials, as well as the hormones required for pregnancy recognition. Pregnancy recognition involves specific hormones such as prolactin in rodents or interferons in ruminants and estrogens in pigs that in their own way ensure the maintenance of the corpus luteum and its secretion of progesterone which is the hormone of pregnancy. However, these pregnancy recognition signals may also modify gene expression in a cell-specific and temporal manner to ensure the growth and development of the conceptus. This chapter provides some historical aspects of the development of understanding of mechanisms for the establishment and maintenance of pregnancy in several species of mammals.

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Endocrinology of pregnancy in the dog: A review

Cited by 76 publications

References 53 publications

A rare case of single pup syndrome and its management in a Labrador bitch

A rare case of single pup syndrome and its management in a Labrador bitch

Use of aglepristone for the treatment of P₄induced insulin resistance in dogs

History of Maternal Recognition of Pregnancy

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Endocrinology of pregnancy in the dog: A review

Cited by 76 publications

References 53 publications

A rare case of single pup syndrome and its management in a Labrador bitch

A rare case of single pup syndrome and its management in a Labrador bitch

Use of aglepristone for the treatment of P4induced insulin resistance in dogs

History of Maternal Recognition of Pregnancy

Contact Info

Product

Resources

About

Use of aglepristone for the treatment of P₄induced insulin resistance in dogs