Endocrinology (Relationships Between the Endocrine and Nervous Systems)

Mackay, EM

doi:10.1146/annurev.me.06.020155.002043

Cited by 4 publications

(3 citation statements)

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“…41 Other than that, saponin may also increase collagen production and accelerate cell epithelization in the wound. 42 Saponin also had an essential role in high glucose-induced wound healing by increasing endothelial cell proliferation. 43 Tannins may also play an essential role in the wound-healing process.…”

Section: Discussionmentioning

confidence: 99%

Wound healing activity and flavonoid contents of purslane (Portulaca grandiflora) of various varieties

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Wound healing activity and flavonoid contents of purslane (Portulaca grandiflora) of various varieties

et al. 2023

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“…Neocapillaries grow into the wound at a rate post-surgery and produce abundant blood vessel networks, thereby improving the supply of oxygen, nutrients, and stem cells for sufficient tissue repair and metabolic waste removal. [45,46] Therefore, it is important to investigate temporal variations in the vascular sprouting process. In this study, we found that IGFBP7 peaked at 1-2 week post-surgery in vivo during normal defect healing, and its early intervention reduced sprouting angiogenesis in the early stage of bone defect healing and impeded the final bone formation quality (Figure 5).…”

Section: Discussionmentioning

confidence: 99%

Osteogenic Differentiated Human Bone Marrow Stem Cells Contribute to Sprouting Angiogenesis Deceleration via Paracrine Excreted IGFBP7

Sun

Cao

Guo

et al. 2022

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process resulting in capillary bed formation. [1,2] However, sprouting angiogenesis can proceed as an overshooting reaction that results in the formation of additional blood vessels, followed by delayed decelerating growth. [3] This decelerating phase occurs simultaneously with the regression of superfluous vessels at a later stage of healing so that vessel beds are pruned back to normal vascular density and vascular homeostasis is maintained; [4] this process is particularly important because uncontrolled vessel growth leads to pathological effects such as proliferative diabetic retinopathy, [5,6] and incorrect vascular patterning causes vessel instability and poor network functionality. [7] Therefore, organized angiogenesis deceleration at the later stage of healing is crucial for vessel normalization and stabilizing the mature vessels, ensuring that tissue regeneration including bone defect healing can be carried out within a controllable range; however, the mechanism behind this remains unclear. Alteration of extrinsic microenvironment, such as hypoxia improvement, is known as a common cause of capillary deceleration, [8,9] yet the decelerating angiogenesis response is usually accompanied by the repairing process of various injured tissue. [10] Therefore, it's reasonable to assume that intrinsic Deceleration of sprouting angiogenesis until its final disappearance after blood vessel reconstruction is crucial for controlled tissue repair; however, its underlying mechanism remains unclear. It is reported that osteogenic differentiated bone marrow stem cells (OD-BMSCs) contribute to sprouting angiogenesis deceleration by releasing intrinsic "OFF" signals. In vitro experiments show that insulin-like growth factor-binding protein 7 (IGFBP7) is the main component of OD-BMSCs paracrine products which could inhibit the tube formation ability of endothelial cells. In addition, cell functional experiments show that IGFBP7 inhibits sprouting angiogenesis by reducing cell migration and tip cell specification. Furthermore, it is found that early IGFBP7 intervention, which accelerates sprouting angiogenesis deceleration during the early stage of healing, impedes bone defect healing. These results demonstrate that OD-BMSCs could offer intrinsic inhibitory signals on sprouting angiogenesis and the appropriate emergence timing of these signals is crucial to maintain vasculature homeostasis during bone repairing. These results provide insight into the complex interaction between osteogenesis-angiogenesis coupling and suggest the potential therapeutic application of IGFBP7 in regulating vascular homeostasis.

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“…The role of the nervous system in exerting control over anterior pituitary Junction is a problem which has received wide and intensive study, much of it stimulated by experiments on the reaction of the organism to stressful stimuli, a reaction in part expressed through changes in nervous system (13,14) and endocrine function (IS, 16). There is a large body of evidence in dicating that neural structures participate in such reactions, but the precise structures involved, and the exact nature of the anatomic and functional connections between the nervous system and the hypophysis remain con troversial matters.…”

Section: Central Nervous System Control Of the Anterior Pituitarymentioning

confidence: 99%