Endocytoscopic microvasculature evaluation is a reliable new diagnostic method for colorectal lesions (with video)

Kudo, Shin‐ei; Misawa, Masashi; Wada, Yoshiki; Nakamura, Hiroki; Kataoka, Shinichi; Maeda, Yukihide; Toyoshima, Naoya; Hayashi, Seiko; Kutsukawa, Makoto; Oikawa, Hiromasa; Mori, Yuichi; Ogata, Noriyuki; Hisayuki, Tomokazu; Hayashi, Takemasa; Wakamura, Kunihiko; Miyachi, Hideyuki; Ishida, Fumio; Inoue, Haruhiro

doi:10.1016/j.gie.2015.04.039

Cited by 45 publications

(40 citation statements)

References 28 publications

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“…EC allows ultra‐magnified images to be captured during endoscopy and has made possible the diagnosis of living tumor cells in vivo . This technique effectively differentiates between neoplastic and non‐neoplastic lesions in the colorectum . For this reason, EC is closer to a ‘virtual biopsy’ than magnifying chromoendoscopy.…”

Section: Discussion Topics Of the Jges Core Sessionsmentioning

confidence: 99%

“…This technique effectively differentiates between neoplastic and nonneoplastic lesions in the colorectum. 22 For this reason, EC is closer to a 'virtual biopsy' than magnifying chromoendoscopy. In this core session, a study whereby EC showed significantly higher diagnostic accuracy for the prediction of neoplastic and non-neoplastic lesions than conventional endoscopy, and correlation between the EC findings and the degree of inflammation as determined by histopathology in UC was described.…”

Section: Discussion Topics Of the Jges Core Sessionsmentioning

confidence: 99%

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Advanced diagnostic endoscopy in the lower gastrointestinal tract: A review of JGES core sessions

Oka

Tanaka

Sano

et al. 2017

Digestive Endoscopy

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At each of the 89th to the 92nd congresses of the Japan Gastroenterological Endoscopy Society, a series of featured discussion sessions concerning advanced diagnostic endoscopy in the lower gastrointestinal tract were presented. In total, 45 lectures were presented in this subject area. It was shown that, in recent years, several convenient and less invasive colonoscopic modalities have been developed. This review article summarizes these core sessions and the efficacy of the techniques discussed.

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Section: Discussion Topics Of the Jges Core Sessionsmentioning

confidence: 99%

Section: Discussion Topics Of the Jges Core Sessionsmentioning

confidence: 99%

Advanced diagnostic endoscopy in the lower gastrointestinal tract: A review of JGES core sessions

Oka

Tanaka

Sano

et al. 2017

Digestive Endoscopy

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“…Thereafter, endocytoscopy (Olympus, Tokyo, Japan), the next generation of ultra‐magnification endoscopy which allows in vivo visualization of glandular structures and cellular atypia, was developed . Endocytoscopy has an advantage of CLE because fluorescein is not required for ultra‐magnified observation . Endocytoscopy includes two types; one is integrated in the distal tip of a standard endoscope (integrated type) and the other is a probe‐based type.…”

Section: Ultra‐magnifying Endoscopymentioning

confidence: 99%

“…Integrated‐type endocytoscope enables 380–580‐fold magnification, whereas the probe‐based type provides 450–1390‐fold magnification . Several studies have reported very high accuracy, sensitivity, specificity or positive predictive value in the histological diagnosis of colorectal polyps . Thus, endocytoscopy is considered a promising tool for advanced endoscopic imaging.…”

Section: Ultra‐magnifying Endoscopymentioning

confidence: 99%

Role of magnifying colonoscopy for diagnosis of colorectal neoplasms: From the perspective of Japanese colonoscopists

Yanai

Nakamura

Matsumoto

2016

Digestive Endoscopy

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Colorectal cancer is the third leading cause of cancer-related death. As the therapeutic strategy for colorectal cancer depends on the clinical stage of the tumor, precise and accurate staging is necessary prior to treatment decision-making. Colonoscopy is an essential tool for detection and prevention of colorectal cancer, as it also allows for removal of adenomatous lesions. Using conventional endoscopy, however, it is sometimes difficult to differentiate neoplastic lesions from non-neoplastic lesions. Several new endoscopic technologies have been developed to provide a more precise diagnosis. Magnifying chromoendoscopy and narrow-band imaging endoscopy with or without magnification are invaluable not only for distinction of colorectal neoplastic lesions from non-neoplastic lesions, but also for the accurate diagnosis of invasion depth in colorectal cancers. Based on an accumulation of a large number of clinical data, the use of magnifying colonoscopy has become inevitable for the prediction of histology and the diagnosis of invasion depth of colorectal neoplasms in Japan.

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“…Recently, the invention of ultramagnifying endocytoscopy (EC) has enabled observation at a 400-fold magnification. As the EC findings correspond well with the pathological findings, it is possible to detect living tumor cells and micro vessels in vivo (3–5) and obtain a pathological image by simply applying the scope to the target mucosa during an endoscopic examination, which serves as a mode of on-site ‘optical biopsy’ (6,7). …”

Section: Introductionmentioning

confidence: 97%

In vivo detection of desmoplastic reaction using endocytoscopy: A new diagnostic marker of submucosal or more extensive invasion in colorectal carcinoma

Sugihara

Kudo

Miyachi

et al. 2017

Molecular and Clinical Oncology

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The pathological determination of desmoplastic reaction (DR) in colorectal carcinoma is useful for predicting extensive submucosal invasion. The aim of the present study was to determine the usefulness of endocytoscopy (EC) in detecting DR. A total of 72 cases of colorectal cancer with submucosal invasion (EC classification, EC3b) were evaluated. The utility of fine granular structure (FGS) observed via EC for the prediction of the presence of DR in the most superficial tumor layers was assessed. Of the 72 lesions, 26 were positive for FGS, and the majority of these lesions (23/26, 88.5%) exhibited a DR, indicating a significant association. The overall accuracy of the identification of FGS via EC that was predictive of a DR was 87.3%. The presence of FGS detected by EC was significantly associated with the presence of a DR, suggesting the clinical usefulness of EC in planning treatment for colon cancer with submucosal invasion.

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Endocytoscopic microvasculature evaluation is a reliable new diagnostic method for colorectal lesions (with video)

Cited by 45 publications

References 28 publications

Advanced diagnostic endoscopy in the lower gastrointestinal tract: A review of JGES core sessions

Advanced diagnostic endoscopy in the lower gastrointestinal tract: A review of JGES core sessions

Role of magnifying colonoscopy for diagnosis of colorectal neoplasms: From the perspective of Japanese colonoscopists

In vivo detection of desmoplastic reaction using endocytoscopy: A new diagnostic marker of submucosal or more extensive invasion in colorectal carcinoma

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