Endodontic Infection and Endothelial Dysfunction Are Associated with Different Mechanisms in Men and Women

Root filled teeth constituted the majority of cases referred to this specialist clinic in endodontics. The majority of these teeth were associated with symptomatic conditions, and antibiotics were prescribed to approximately 20% of the patients referred for a root filled tooth. The findings suggest that symptomatic root filled teeth may be a substantial clinical problem in general dentistry and contribute to avoidable prescription of antibiotics.

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“…A possible gender‐dependent variation in the reaction to endodontic infection has also recently attracted attention (Cotti et al . ).…”

Section: Discussionmentioning

confidence: 97%

Characteristics of teeth referred to a public dental specialist clinic in endodontics

et al. 2016

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“…, Cotti et al . , , Gomes et al . ), or as a primary method followed by additional radiographic methods, only when a radiolucent lesion was detected on the panoramic radiographs (Aleksejuniene et al .…”

Section: Reviewmentioning

confidence: 99%

“…) and measurement of plasma markers (Cotti et al . , ). The heterogeneity in the outcome definitions between studies makes it difficult or ill‐advised to combine the results from different studies.…”

Section: Reviewmentioning

confidence: 99%

Association between apical periodontitis and cardiovascular diseases: a systematic review of the literature

2016

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A systematic review was conducted to assess the association between apical periodontitis (AP) and cardiovascular disease (CVD). Studies published from the earliest date available until September 2015 were retrieved from the Medline, PubMed and Embase databases. The included studies reported the results from observational studies and assessed the link between AP and CVD as confirmed by one of the following criteria: diagnosed coronary artery disease, angina pectoris, acute myocardial infarction, stroke or mortality caused by cardiac pathology. The study characteristics were abstracted by independent researchers following the PRISMA standard protocol. NOS criteria were used to rate the quality of the studies, and the GRADE was used for level of evidence evaluation. Nineteen epidemiological studies fulfilled the predetermined inclusion criteria: 10 case-control studies, five cross-sectional studies and four cohort studies. There was considerable heterogeneity amongst the included studies in terms of their study design, population, outcomes of interest and AP evaluation methods. Considering the limited availability and the heterogeneity amongst the studies, meta-analysis was not attempted. Thirteen of the 19 included studies found a significant positive association between apical periodontitis and cardiovascular disease, although in two of them, the significance was present only in univariate analysis. Five studies failed to reveal positive significance, and one study reported a negative association. In conclusion, although most of the published studies found a positive association between apical periodontitis and cardiovascular disease, the quality of the existing evidence is moderate-low and a causal relationship cannot be established.

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“…Os trabalhos de Cotti et al 10 realizados em 2015 investigaram uma ligação potencial entre a periodontite apical (PA) e a função cardiovascular (CV). Para tanto, marcadores de inflamação, reserva de fluxo endotelial (EFR) e níveis de dimetilarginina assimétrica (ADMA), o inibidor endógeno do óxido nítrico sintase (NOS), foram medidos em adultos jovens com PA, de ambos os sexos (20 homens e 21 mulheres), com idade entre 20 a 40 anos.…”

Section: Resultsunclassified

Infecção endodôntica associada a alterações no sistema cardiovascular

Saviczki¹,

Rebouças²,

Guerisoli³

et al. 2017

Arch Health Invest

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ResumoHá décadas tem se estudado a associação de doenças orais e sistêmicas, embora a relação de causa e efeito ainda não tenha sido claramente estabelecida. Com o ressurgimento da teoria da infecção focal, outros estudos analisaram a relação entre a existência do foco infeccioso de natureza bacteriana com a possibilidade de disseminação, o que pode condicionar a doenças sistêmicas, como, por exemplo, a endocardite bacteriana. Nesse sentido, a verificação da disseminação microbiana como fator de risco para doenças cardíacas tem sido investigada em vários estudos. Análises epidemiológicas demonstraram a relação entre a doença periodontal crônica e doença cardíaca coronariana, acidente vascular cerebral, prematuridade e baixo peso ao nascimento e doença respiratória. Entretanto, o papel da periodontite apical (PA) associada a infecções endodônticas no desenvolvimento de alterações sistêmicas tem sido alvo de poucos estudos. As infecções periodontais e as infecções endodônticas têm uma microbiologia complexa e estão associadas a níveis elevados de citocinas. O objetivo deste trabalho foi caracterizar a produção científica publicada nos últimos 5 anos relacionando PA com doenças cardiovasculares (DVC) e descobrir quais as principais alterações cardíacas ligados aos estudos de PA. Descritores: Endodontia; Periodontite Periapical; Doenças Cardiovasculares. AbstractThe association of oral and systemic diseases has been studied for decades, although the cause and effect relationship has not yet been clearly established. With the resurgence of the focal infection theory, other studies have analyzed the relationship between the existences of the infectious focus of bacterial nature with the possibility of dissemination, which can lead to systemic diseases, such as bacterial endocarditis. In this sense, the verification of microbial spread as a risk factor for heart disease has been investigated in several studies. Epidemiological analyzes have demonstrated the relationship between chronic periodontal disease and coronary heart disease, stroke, prematurity and low birth weight and respiratory disease. However, the role of associated apical periodontitis (AP) to endodontic infections in the development of systemic alterations has been the subject of few studies. Periodontal infections and endodontic infections have a complex microbiology and are associated with elevated levels of cytokines. The aim of this study was to characterize the scientific production published in the last 5 years relating AP to CVD cardiovascular diseases and to discover the main cardiac alterations related to AP studies. Descriptors: Endodontics; Periapical Periodontitis; Cardiovascular Diseases. ResumenEn las últimas décadas se ha estudiado la asociación de enfermedades orales y sistémicas, aunque la relación de causa y efecto aún no ha sido claramente establecida. Con el resurgimiento de la teoría de la infección focal, otros estudios analizaron la relación entre la existencia del foco infeccioso de naturaleza bacteriana con la posibilidad de dise...

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Endodontic Infection and Endothelial Dysfunction Are Associated with Different Mechanisms in Men and Women

Cited by 40 publications

References 45 publications

Characteristics of teeth referred to a public dental specialist clinic in endodontics

Characteristics of teeth referred to a public dental specialist clinic in endodontics

Association between apical periodontitis and cardiovascular diseases: a systematic review of the literature

Infecção endodôntica associada a alterações no sistema cardiovascular

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