Endogenous androgen levels and cardiovascular risk profile in women across the adult life span

Bell, Robin Jean; Davison, Sonia Louise; Papalia, Mary-Anne; McKenzie, Dean Philip; Davis, Susan R.

doi:10.1097/gme.0b013e31802b6cb1

Cited by 67 publications

(39 citation statements)

References 37 publications

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“…Yasui et al 60 found that associations of SHBG with HDL-C and triglycerides were no longer significant after controlling for BMI. In another study, a similar lack of independence was observed for the association with HDL-C. 64 Conversely, in several studies associations between SHBG and triglycerides 5,6,55,64 and HDL-C 5,17 persisted after adjustment for BMI or WHR. In the study of Lambrinoudaki et al, 5 associations of TT and FT with triglycerides and HDL-C were not explained by BMI.…”

Section: Lipid Profilementioning

confidence: 67%

Testosterone, SHBG and cardiovascular health in postmenopausal women

Brand

Schouw

2010

Int J Impot Res

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Cardiovascular disease (CVD) affects men and women differently with women having a lower incidence and later onset of disease. Research has recently refocused interest on the cardiovascular role of androgens. The purpose of this review is to summarize the evidence available on the association between testosterone and cardiovascular health in postmenopausal women. Published studies relating testosterone and sex hormone-binding globulin (SHBG) to CVD and its risk factors were reviewed. Studies included in this review suggest that increased androgenicity, characterized by high testosterone and low SHBG levels, is associated with an adverse CVD risk factor profile in postmenopausal women. However, evidence for an association with cardiovascular events is lacking and it is uncertain whether the observed associations with endogenous testosterone have clinical implications regarding the use of postmenopausal testosterone therapy. Large-scale, longitudinal studies relating testosterone and SHBG levels to cardiovascular risk factors and endpoints are needed to determine the temporal relationship between androgenicity and cardiovascular risk and to ascertain the long-term efficacy and safety of testosterone therapy in postmenopausal women.

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Section: Lipid Profilementioning

confidence: 67%

Testosterone, SHBG and cardiovascular health in postmenopausal women

Brand

Schouw

2010

Int J Impot Res

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“…51 Other investigators have suggested that SHBG, not androgen production, is the primary marker of insulin resistance, and that the SHBG level has independent predictive power for cardiovascular risk for women. 83 Both of these studies were cross-sectional but prospective studies, including a nested case-controlled study, showed weak trends toward increased risk of CVD among women having higher androgen/estrogen ratios: among postmenopausal women not taking any hormone therapy, women with lower SHBG or with high free androgen indexes were at increased risk of CVD events. 84 Basic science 85 and clinical 86 data suggest that exogenous testosterone administration to women may promote abdominal fat deposition.…”

Section: Systemic Estrogenmentioning

confidence: 99%

Women's sexual function and dysfunction: current uncertainties, future directions

Basson

2008

Int J Impot Res

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There is increasing evidence that women at the outset of sexual activity do not need to have sexual desire, as in 'drive', and that many do not distinguish desire from arousal. Multiple modes of investigation confirm poor correlation between women's subjective arousal and measured genital congestion. Suggested revisions to the DSM-IV definitions of sexual disorder have been published: there is now need to align interview assessments and screening questionnaires with contemporary understanding of women's sexual response. Whereas the psychological factors associated with women's sexual function and resilience to biological insults and external stressors are well documented, the role of biological factors is less clear. Variations in the rate of decline of adrenal and ovarian pro-hormones, activity of converting enzymes in peripheral cells, sensitivity of androgen and estrogen receptors and cerebral production of sex steroids may all be involved. Thus there is great complexity underlying the question of sex hormone supplementation, and in particular, little clarity as to which women have decreased brain and/or peripheral androgen activity. When psychosexual etiological factors appear to be minimal and investigational testosterone supplementation is considered, it would be appropriate to target women with disordered arousal and desire in keeping with the recently recommended revised definitions.

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“…(26) Bell RJ et al study showed a low SHBG levels detect CVS risk profile with a significant association for HDL-C (p < 0.01) and TG (p < 0.01) in both premenopausal and postmenopausal women, but not significant in this study with HDL-C (r= -0.003, p= NS) and TG (r= -0.045, p= NS). (27) The correlation of DHEA with age (r= -0.197, p < 0.05) was negative in accordance of fact that DHEA in women declines in a linear fashion with age. (24) The pool of androgens in women decreases progressively from the age of 30 years in parallel with the decrease in serum concentration of DHEA.…”

Section: Discussionmentioning

confidence: 81%

A Study of Association of Sex Hormones With Insulin Resistance and Obesity for Diabetes Mellitus Risk in Adult Women

Suganthy¹,

Mohanty²,

Jeyakumar³

et al. 2017

jemds

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BACKGROUNDSex hormones have a great impact on energy metabolism, body composition, vascular function and inflammatory responses and insulin resistance. Ovarian hormones influence insulin sensitivity across the lifespan of women. DM prevalence also affects women's health across the life stages causing the second highest mortality in South Asians. DM has polyfactorial aetiological differences between males and females. There is need of search of sex/gender specific risk factors of DM in middle aged women. Therefore, this study is undertaken to analyse the association of sex hormones with insulin resistance, obesity and lipid profile thereby to assess the DM risk.

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Endogenous androgen levels and cardiovascular risk profile in women across the adult life span

Cited by 67 publications

References 37 publications

Testosterone, SHBG and cardiovascular health in postmenopausal women

Testosterone, SHBG and cardiovascular health in postmenopausal women

Women's sexual function and dysfunction: current uncertainties, future directions

A Study of Association of Sex Hormones With Insulin Resistance and Obesity for Diabetes Mellitus Risk in Adult Women

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