A Master Regulator of Oxidative Stress - The Transcription Factor Nrf2 2016
DOI: 10.5772/65715
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Endogenous Antioxidants: A Review of their Role in Oxidative Stress

Abstract: Oxidative stress (OxS constitutes a disturbance caused by an imbalance between the generation of free radicals and antioxidant system, which causes damage to biomolecules. This, in turn, may lead the body to the occurrence of many chronic degenerative diseases. Therefore, it is very important to know the functioning of those endogenous (and exogenous antioxidants systems to prevent such diseases. Due to evolutionary conditions in living beings, among other functions have been developed and selected defense sys… Show more

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Cited by 65 publications
(53 citation statements)
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“…Living cells produce endogenous anti-oxidative factors, which buffer the generated free radicals and provide protection to the cells against oxidative injury. The most prominent endogenous antioxidant molecules are GSH, SOD, and CAT [ 36 ]. When the free radicals produced exceed the ability of the cell to neutralize them through antioxidant molecules, a condition called oxidative stress occurs [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…Living cells produce endogenous anti-oxidative factors, which buffer the generated free radicals and provide protection to the cells against oxidative injury. The most prominent endogenous antioxidant molecules are GSH, SOD, and CAT [ 36 ]. When the free radicals produced exceed the ability of the cell to neutralize them through antioxidant molecules, a condition called oxidative stress occurs [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…The elevated expression of cat and gpx genes in the gut might be due to the high levels of LC-PUFA in the supplemented diets, which are highly susceptible to oxidation. Catalase is a tetrameric porphyrin-containing enzyme that catalyzes the conversion of H 2 O 2 to water and molecular oxygen, thereby maintaining cellular redox balance; glutathione peroxidase plays an important role in detoxifying lipids and hydroperoxides and protecting cellular components from oxidative damage during events such as phagocytosis or physiological metabolism [56,57]. Alternatively, the increased expression of cat and gpx may indicate higher scavenging potential for reactive oxygen species inside the gut, thereby offering a defense mechanism against oxidative damage.…”
Section: Activation Of Factors Associated With Antibacterial Effect Amentioning
confidence: 99%
“…Antioxidant systems play an important role in maintaining redox balance. Among the main endogenous antioxidants that participate in various physiological and pathological processes, there are antioxidant proteins, which have enzymatic activity, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and non-enzymatic antioxidants, which are molecules capable of rapidly neutralizing ROS, like glutathione, lipoic acid, bilirubin, ferritin [10,11].…”
Section: Reactive Oxygen Species: the Patho-physiological Rolementioning
confidence: 99%