Endogenous Estrogens Increase Postischemic Hyperemia in the Skin Microcirculation

Stojanović, Vesna; Küng, Fides; Spieker, Lukas E.; Binggeli, Christian; Sudano, Isabella; Hayoz, Daniel; Lüscher, Thomas F.; Noll, Georg

doi:10.1097/01.fjc.0000157457.83809.94

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Estrogen is thought to upregulate NO production within the endothelial cells of the vasculature [16,18], thus increasing skin blood flow. Previous studies have also shown estrogen to increase skin blood flow during RH [15,42]. The effects of progesterone on the skin microcirculation are less understood and, to date, have not been independently investigated.…”

Section: Introductionmentioning

confidence: 99%

17β-Estradiol and Progesterone Independently Augment Cutaneous Thermal Hyperemia But Not Reactive Hyperemia

et al. 2011

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OBJECTIVE We examined the impact of estradiol and progesterone on skin local heating and reactive hyperemia in 25healthy women. METHODS Subjects were studied 3 times over 10–12 days. Endogenous sex hormones were suppressed with agonadotropin-releasing hormone antagonist. Subjects were studied on day 4 of suppression (study-day 1),3–4 days later following treatment with either 17β-estradiol or progesterone (study-day 2), and another 3–4 days later, following treatment with both estradiol and progesterone (study-day 3). Subjects underwent identical local heating and reactive hyperemia protocols on all study days. Local heating is characterized by an initial peak in blood flow, followed by a prolonged plateau. A brief nadir is seen between the phases. RESULTS Blood flow values are expressed as percent maximum cutaneous vascular conductance (CVC). Estradiol alone increased initial peak CVC from 71±2 to 79±2% (p=0.001). Progesterone alone increased initial peak CVC from 72±2 to 78±2% (p=0.046). Neither estradiol nor progesterone increased plateau CVC. No significant changes were seen between study days 2 and 3 for either group. No differences were observed in reactive hyperemia. CONCLUSION Both estradiol and progesterone increased initial peak CVC during local heating, without altering plateau CVC. There was no additive effect of estradiol and progesterone.

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Section: Introductionmentioning

confidence: 99%

17β-Estradiol and Progesterone Independently Augment Cutaneous Thermal Hyperemia But Not Reactive Hyperemia

et al. 2011

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“…The observed enhanced skin viability in this study may partially be due to estrogens' effect on skin microcirculation. Stojanovic et al (17) showed that endogeneous estrogens increases postischemic hyperemia in the skin microcirculation. Sex steroid hormones are known to have signifi cant contributions on the regulation of cutaneous repair processes (37).…”

Section: Discussionmentioning

confidence: 99%

“…Estrogens have been recognised as a regulator of vascular tone and structure particularly in the skin. The skin microcirculation has been shown to be impaired if estrogen defi ciency is present (17). Also, it has been shown that estrogen supplementation accelerates cutaneous wound healing in elderly patients (13).…”

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confidence: 99%

The effect of ovariectomy on the skin flap viability and myeloperoxidase levels

Coşkun¹,

Arıkan²,

Çoban³

et al. 2014

BLL

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Objectives: Estrogen could affect the rate and quality of wound healing in skin. We aimed to investigate the effects of ovariectomy on skin fl ap viability and myeloperoxidase (MPO) levels in a rat model. Background: Estrogens have many important benefi cial and protective roles in skin that they improve collagen content and quality, maintain skin thickness and enhance vascularization. It has been shown that estrogen supplementation accelerates cutaneous wound healing in elderly patients. Methods: Forty-eight cycling female Wistar albino rats were randomly divided into three groups (n = 16); ovariectomy (Group 1), sham (Group 2), and control (Group 3). Rats were subjected to bilateral ovariectomy in the Group 1, and only laparotomy in the Group 2. Twenty-one days later in the Group 1 and 2, a dorsal caudally based skin fl ap elevation was done. In the Group 3, the rats had a dorsal skin fl ap without any surgical intervention. Ten days later, the fl aps were harvested for histopathologic examination and biochemical analyses. Results: The rats in the Group 1 had signifi cantly larger necrotic area and lower fl ap viability than in the Group 2 and 3 (p<0.05). Histopathologic examination showed that necrotic fl ap regions contained muscle necrosis with an abundant neutrophil infi ltration, and severe edema in the Group 1. The MPO activity in the distal of skin fl aps was signifi cantly higher in the Group 1 compared to the Group 2 and 3 (p<0.05). Conclusion: This study shows that ovariectomy has deleterious effects on skin fl ap viability in a rat model (Tab. 1, Fig. 6, Ref.

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