Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy

Abstract

The developing nanoparticle therapeutic agents triggered by tumor microenvironment are a feasible strategy for the substantial elevation of accuracy of diagnosis and the reduction of side effects in cancer treatments. Dysregulated H2S production from the enzyme system of overexpressed cystathionine β-synthase has long been considered to act as an autocrine and paracrine factor for the tumor growth and proliferation of colon cancer. Herein, for the first time, an endogenous H2S-activated copper metal–organic framework (Cu-MOF; HKUST-1) nanoenzyme has been demonstrated to synergistically mediate H2S-activated near-infrared photothermal therapy and chemodynamic therapy in the effective treatment of colon cancer. This endogenous biomarker-triggered “turn-on” strategy to generate therapeutic agents in situ could largely simplify the constitution of nanomedicine by avoiding the cargo introduction and thus supply great promise for the precise treatments of colon cancer.

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

“…Similar to the case in iron‐mediated Fenton reaction‐based CDT, the heat generated by PTT can promote copper‐involved Fenton‐like reaction, thus enhancing copper‐mediated CDT. [ 221–235 ] For example, black phosphorus (BP) is a biocompatible and biodegradable 2D nanomaterial, and has been frequently employed as a photothermal agent (PTA). [ 236 ] Hu and co‐workers designed BP@Cu nanostructures for CDT‐enhanced PTT and positron emission tomography (PET) imaging ( Figure a).…”

H2S‐Scavenged and Activated Iron Oxide‐Hydroxide Nanospindles for MRI‐Guided Photothermal Therapy and Ferroptosis in Colon Cancer

“…Recently, several H 2 S‐activated photothermal agents have been applied in treating colorectal cancer. [ 10,15 ] Particularly, inorganic Cu 2 O based nanoparticles could be sulfidated as Cu 9 S 8 within the colorectal tumors, presenting the photothermal capability with NIR irradiation. [ 16 ] However, the performance of H 2 S removal has not been investigated and the potential toxicity caused by Cu element could not be easily ignored.…”

Biomimetic smart nanoplatform for dual imaging-guided synergistic cancer therapy

“…[25][26][27] For instance, MOFs of Cu-porphyrin derivatives have been designed for PDT with depletion of GSH and H 2 O 2 levels in the TME. 28 The integration of Mn into porphyrin MOFs has been proven to be a promising agent for PTT and MRI. 29,30 In addition, the ease of surface functionalization/doping endows MOFs with versatile properties and stimuli-responsive imaging or controlled release.…”