Endogenous Nocardia farcinica endophthalmitis

Kawakami, Hideaki; Sawada, Akira; Mochizuki, Kiyofumi; Takahashi, Ken; Muto, T; Ohkusu, Kiyofumi

doi:10.1007/s10384-009-0782-4

Cited by 10 publications

(6 citation statements)

References 3 publications

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“…The uveitis was confirmed by cultures of the blood, vitreous, or aqueous humor in all cases. The findings in 3 of these patients (Patients 6, 7, and 12) were reported previously [ 9 – 11 ].…”

Section: Methodssupporting

confidence: 71%

“…The main outcome measure was the best-corrected VA at the final follow-up examination. In earlier reports [ 9 , 12 ], a best-corrected VA of counting fingers (CF) or better was classified as being a good visual outcome for the statistical analyses; however in this report we used 20/200 or better as a good visual outcome. Other outcome measures included the results of microbiological investigations and anatomical and clinical outcomes.…”

Section: Methodsmentioning

confidence: 99%

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An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis

Nishida

Ishida

Niwa

et al. 2015

Journal of Ophthalmology

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Purpose. To determine the clinical features, microbial profiles, treatment outcomes, and prognostic factors for endogenous bacterial endophthalmitis (EBE). Methods. The medical records of 27 eyes of 21 patients diagnosed with EBE for 11 years were reviewed. Collected data included age, site of infection, visual acuities (VAs), microbial profiles, and treatment regimen. Results. The mean age was 68.5 years. Gram-positive organisms accounted for 76.2%, while gram-negative ones accounted for 19.0%. Staphylococcus aureus was the most common causative organism (52.3%) of which 72.7% was methicillin-resistant S. aureus. A final VA of ≥20/40 was achieved in 44% and 20/200 or better was in 64%. Eyes with initial VA of ≥20/200 (P = 0.003) and focal involvements (P = 0.011) had significantly better final VA. Initial VA (P = 0.001) and the interval between onset of ocular symptoms and intravitreal antibiotic injection (P = 0.097) were associated with final VA in eyes receiving intravitreal antibiotics. Conclusions. EBE is generally associated with poor visual outcome; however the prognosis may depend on initial VA, extent of ocular involvement, and an interval between onset of ocular symptoms and intravitreal antibiotic injection. Early diagnosis and early intravitreal injection supplement to systemic antibiotics might lead to a relatively good visual outcome.

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Section: Methodssupporting

confidence: 71%

Section: Methodsmentioning

confidence: 99%

An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis

Nishida

Ishida

Niwa

et al. 2015

Journal of Ophthalmology

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“…Most reported cases of intraocular Nocardia farcinica infection have occurred secondary to haematogenous spread from a primary pulmonary infectious focus in immunocompromised individuals [ 3 – 6 , 10 ]. There have been two reported cases of post-operative and post-traumatic endophthalmitis caused from Nocardia farcinica [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

The role of oral co-trimoxazole in treating Nocardia farcinica keratitis: a case report

Sharma

O’Hagan

2016

J Ophthal Inflamm Infect

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Nocardia farcinica is one of the more recently identified species of the Nocardia genus. Nocardia farcinica keratitis is a rare occurrence, with only eight previously reported cases. Semi-permeable rigid contact lens use was associated with one of these reported cases. We report the first case of an extended wear soft contact lens-related Nocardia farcinica keratitis and recommend a new treatment regime. A 47-year-old lady presented with a right eye keratitis after wearing her extended wear soft contact lenses for five continuous weeks. There was no history of trauma or swimming with contact lenses in. Empirical ciprofloxacin and tobramycin eye drops were not tolerated due to ocular surface irritation on application, and instead, empirical treatment was with chloramphenicol and fortified gentamicin 1.5 % eye drops. Corneal scrapings grew Nocardia farcinica after 3 weeks—sensitive to amikacin and co-trimoxazole. Treatment was changed to amikacin 2.5 % eye drops, resulting in partial resolution of the corneal infiltrates. Oral co-trimoxazole 160 mg/800 mg BD was added, due to cultured drug sensitivity and its high ocular penetration, with good results and a final right eye best-corrected visual acuity of 6/5. Nocardia farcinica keratitis should be considered in the differential diagnosis of contact lens-related keratitis. We report the first case occurring in association with extended wear soft contact lenses. Nocardia species can mimic fungal and acanthamoeba keratitis. Treatment with oral co-trimoxazole has not been previously reported. This case demonstrates the role of co-trimoxazole in treating Nocardia farcinica keratitis based on cultured drug sensitivities.

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“…87.1). Grampositive agents associated with bacterial endogenous endophthalmitis include Staphylococcus areus, 21 group B Streptococcus, 22 Streptococcus pneumoniae, 23 Streptococcus bovis, 24 Propionibacterium acnes, 25 Listeria monocytogenes, 26 Bacillus spp., 27 Nocardia spp., 28 and others. Grampositive agents associated with bacterial endogenous endophthalmitis include Staphylococcus areus, 21 group B Streptococcus, 22 Streptococcus pneumoniae, 23 Streptococcus bovis, 24 Propionibacterium acnes, 25 Listeria monocytogenes, 26 Bacillus spp., 27 Nocardia spp., 28 and others.…”

Section: Endogenous Bacterial Endophthalmitismentioning

confidence: 96%