Endogenous opiates and behavior: 2014

Bodnar, Richard J.

doi:10.1016/j.peptides.2015.10.009

Cited by 74 publications

(83 citation statements)

References 1,129 publications

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“…187 Small opioid peptides are involved in reward processing, drug addiction, and pain perception. 188 M-ENK has an electroactive moiety of tyrosine, which, similar to tryptophan in gonadotropin-releasing hormone release, can cause fouling on the electrode surface. Thus the Sombers group developed a sawhorse waveform for M-ENK that reduces the fouling by using different scan rates for different segments of the scan and holding at the anodic limit for 3 milliseconds to clean the electrode surface.…”

Section: Electrochemical Detection Of Neurotransmittersmentioning

confidence: 99%

Analytical Techniques in Neuroscience: Recent Advances in Imaging, Separation, and Electrochemical Methods

et al. 2016

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Section: Electrochemical Detection Of Neurotransmittersmentioning

confidence: 99%

Analytical Techniques in Neuroscience: Recent Advances in Imaging, Separation, and Electrochemical Methods

et al. 2016

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“…Opioid neuropeptides and receptors are distributed widely in the brain and are well-studied for roles in addiction, learning and memory, feeding, analgesia, and reward (e.g., [7]). Endogenous opioid systems also regulate social behaviors, including behaviors that change in association with social ascension or defeat (e.g., sexual and agonistic behaviors), suggesting opioids as candidate modulators of status-appropriate behavior.…”

Section: Introductionmentioning

confidence: 99%

Prodynorphin and kappa opioid receptor mRNA expression in the brain relates to social status and behavior in male European starlings

Riters

Cordes

Stevenson

2017

Behavioural Brain Research

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Numerous animal species display behavioral changes in response to changes in social status or territory possession. For example, in male European starlings only males that acquire nesting sites display high rates of sexual and agonistic behavior. Past studies show that mu and delta opioid receptors regulate behaviors associated with social ascension or defeat. Opioids also act at kappa receptors, with dynorphin binding with the highest affinity; however, the role of these opioids in social behavior has not been well studied. We observed flocks of male starlings during the breeding season and ran quantitative real-time polymerase chain reaction (qPCR) to measure expression of kappa opioid receptors (OPRK1) and prodynorphin (PDYN) in brain regions involved in social behavior and motivation (ventral tegmental area [VTA], medial preoptic nucleus [mPOA]) and vocal behavior (Area X). Males with nesting territories displayed more sexual/agonistic behavior than males without nesting territories. They also had lower OPRK1 expression in VTA and mPOA. OPRK1 expression in VTA correlated negatively with sexual/agonistic behaviors, consistent with past studies showing kappa receptors in VTA to inhibit sociosexual behaviors. PDYN in mPOA correlated negatively with a measure of nesting behavior that may also reflect sexual motivation. PDYN in Area X related positively to song. Distinct patterns of OPRK1 and PDYN expression in VTA, mPOA, and Area X related to gonad volume, suggesting that breeding condition may modify (or be modified by) OPRK1 and PDYN expression. Studies are now needed to further characterize the role of OPRK1 and PDYN in status-appropriate social behaviors.

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“…This new knowledge may promote the development of a suitable dose strategy of pentazocine in women with or without MOR blockade. Considering the involvement of opioid receptors in various traits, such as learning and memory, addiction, stress and depression, antipruritic effect, diuresis, and reproductive function, it is possible that estrogen can modulate opioid-mediated effects on these traits as well [16, 45, 46]. …”

Section: Discussionmentioning

confidence: 99%

Estrogen facilitates and the kappa and mu opioid receptors mediate antinociception produced by intrathecal (−)-pentazocine in female rats

Robinson

Nag

Mokha

2016

Behavioural Brain Research

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Pentazocine, a mixed-action kappa opioid receptor (KOR) agonist, has high affinity for both KOR and the mu opioid receptor (MOR), and has been shown clinically to alleviate pain with a pronounced effect in women. However, whether local application of pentazocine in the spinal cord produces antinociception and the contribution of spinal KOR and MOR in mediating the effect of pentazocine in female rats remain unknown. Also, it is not known whether pentazocine-induced antinociception in females is estrogen-dependent. Hence, we investigated whether intrathecal (i.t.) (−)-pentazocine produces thermal antinociception and whether estrogen modulates the drug effect in female rats. Only the highest dose of pentazocine (500 nmol) was effective in producing antinociception in ovariectomized (OVX) rats. In contrast, pentazocine produced antinociception in estradiol-treated ovariectomized females (OVX+E) rats with the lowest effective dose being 250 nmol. KOR or MOR mediated the effect of the lowest effective dose in OVX+E rats; however, MOR blockade extended the KOR-mediated effect of 500 nmol pentazocine in both groups. In normally cycling females, the 250 nmol dose was effective in producing antinociception at the proestrous, but not at the diestrous stage of the estrous cycle. Thus, estrogen facilitates and KOR or MOR mediate the antinociceptive effect of i.t. (−)-pentazocine in female rats. Selective doses of (−)-pentazocine, with or without MOR blockade, may have a therapeutic benefit.

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Endogenous opiates and behavior: 2014

Cited by 74 publications

References 1,129 publications

Analytical Techniques in Neuroscience: Recent Advances in Imaging, Separation, and Electrochemical Methods

Analytical Techniques in Neuroscience: Recent Advances in Imaging, Separation, and Electrochemical Methods

Prodynorphin and kappa opioid receptor mRNA expression in the brain relates to social status and behavior in male European starlings

Estrogen facilitates and the kappa and mu opioid receptors mediate antinociception produced by intrathecal (−)-pentazocine in female rats

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