Endogenous prostaglandins in peptic ulcer disease.

Baker, Robert D.; Jaffe, Bernard M.; Venables, C W

doi:10.1136/gut.20.5.394

Cited by 30 publications

(4 citation statements)

References 35 publications

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“…The levels of plasma prostaglandins found in our control patients are higher than those found in healthy adults (12,13), although they were similar to those described by Yamashiro et al in a recent pediatric study (14). We did not find any difference in plasma prost aglandin between children of different age in our study.…”

Section: Gastric Juice Prostaglandinssupporting

confidence: 87%

Plasma and Gastric Juice Levels of Prostaglandins in Critically Ill Children

Lopez‐Herce,

Codoceo,

Delgado

et al. 1992

J. pediatr. gastroenterol. nutr.

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SummaryThe levels of prostaglandin (PG) E2 and 6‐keto‐PGF1α (stable metabolite of prostacyclin) in plasma and gastric juice were determined in 113 critically ill children and adolescent, and compared to those registered in a plasma control group of 24 children and a gastric juice control group of 15. The gastric juice concentration of PGE2 is our patients [9.2 × 3.1 (SEM) pg/ml] was significantly lower (p = 0.001) than in the control group [81.1 × 18.1 (SEM) pg/ml]. There were no differences in plasma levels of PGE2 and plasma gastric juice levels of 6‐ketoPGF1α between the patients and the control groups. Children who died had lower plasma levels of PGE2 [6.2 × 2.2 (SEM) pg/ml] and gastric juice levels of PGE2 [2.3 × 0.8 (SEM) pg/ml] than the survivors (p < 0.05). The gastric juice concentration of PGE2 was also lower in children who suffered important upper gastrointestinal bleeding, although the difference did not reach statistical significance.

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Section: Gastric Juice Prostaglandinssupporting

confidence: 87%

Plasma and Gastric Juice Levels of Prostaglandins in Critically Ill Children

Lopez‐Herce,

Codoceo,

Delgado

et al. 1992

J. pediatr. gastroenterol. nutr.

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“…The gastric mucosal PG level in patients with gastric ulcer was lower than the normal volunteers (15,16). There was no difference between the levels found in the patients with duodenal ulcer and those of the normal volunteers (16)(17)(18). These findings raise the possibility that OPC-12759, in causing an increment in gastric mucosal PG content, may prove to be a useful anti gastric ulcer agent.…”

Section: Discussionmentioning

confidence: 44%

Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer, and gastric secretion in rats.

et al. 1989

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“…Rachmilewitz et al 27 ) and Sharon P et al 28 ) found that cultured gastric and duodenal mucosa synthesized significantly less prostanoids in duodenal ulcer patients and they concluded that a decrease in endogenous prostanoid synthesis might have an important pathogenic role in peptic ulcer diseases. In contrast to these observations, Schlegel et al 19 ) reported higher levels of the mucosal prostaglandin in gastric ulcer patients than normals and Tonnesen et al 29 ) , Cheung et al 2 ) , Ligumsky et al 21 ) , and Baker et al 30 ) had failed to confirm this PGE deficiency in patients with duodenal ulcer.…”

Section: Discussionmentioning

confidence: 94%

Distribution of Prostaglandin E2 in Gastric and Duodenal Mucosa: Possible Role in the Pathogenesis of Peptic Ulcer

Park

Yoo

Lee

et al. 1992

Korean J Intern Med

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BackgroundProstaglandin E which is present abundantly in the gastric mucosa is a powerful inhibitor of gastric acid secretion and a stimulus to gastric mucus production. In addition, prostaglandin E2 inhibits ulcer formation in animals, and the synthetic analogues of prostaglandin E have successfully been used in the treatment of patients with gastric and duodenal ulcer disease. To evaluate the role of endogenous prostaglandin E2 in the pathogenesis of the peptic ulcer disease, we measured mucosal prostaglandin E2 levels in patients with gastric and duodenal ulcer disease and compared with that of non-ulcer control persons.MethodsThe study population was made up of 44 non-ulcer persons, 36 patients with a benign gastric ulcer, and 48 with a duodenal ulcer. Every mucosai specimen, taken from the antrum and from the duodenal bulb, were homogenized, mixed with 1 M HCI, and centrifuged. After removal of the supernatant, precipitate was eluted with ethyl acetate in the Amprep C18 minicolumn. Then the extracted prostaglandin E2 in the ethyl acetate fractions was converted into its methyl oximate derivatives, and the prostaglandin E2 level was measured by radioimmunoassay. During the procedure any homogenized specimen which was looking grossly bloody was removed from the assay in order to avoid any possible contamination or prostaglandin E2 in blood.ResultsIn non-ulcer persons, the mean values was 258.17±127.03 pg/mg. tissue in antrum and 121.07±67.46 pg/mg. tissue in duodenal bulb. The corresponding values were 186.42±70.51 pg/mg. tissue, 79.44±39.04 pg/mg. tissue in gastric ulcer patients and 204. 94 92.03 pg/mg. tissue, 99.66±56.10 pg/mgl. tissue in duodenal ulcer patients respectively. Gastric ulcer patients have the significantly lower level of the antral and duodenal prostaglandin E2 (p<0.005). Those levels of duodenal ulcer patients were also significantly lower than those of non-ulcer persons (p<0.025 & 0.05). Antral prostaglandin E2 level increased to 305.21±104.91 pg/mg. tissue in the gastric ulcer patients (p<0.005) and to 271.02±93.23 pg/mg. tissue in the duodenal ulcer (p<0.005) when the ulcer crater was healed. The duodenal bulb prostaglandin E2 level was also increased in the healed stage of ulcer, e. g., 128.84±57.62 (p<0.005) and 112.60±42.25 pg/mg. tissue, respectively.ConclusionThese results suggest that prostaglandin deficiency in the antral and duodenal bulb mucosa may have an important role in the pathogenesis of peptic ulcer disease.

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Endogenous prostaglandins in peptic ulcer disease.

Cited by 30 publications

References 35 publications

Plasma and Gastric Juice Levels of Prostaglandins in Critically Ill Children

Plasma and Gastric Juice Levels of Prostaglandins in Critically Ill Children

Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer, and gastric secretion in rats.

Distribution of Prostaglandin E2 in Gastric and Duodenal Mucosa: Possible Role in the Pathogenesis of Peptic Ulcer

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