2016
DOI: 10.1038/ncomms13101
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Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2

Abstract: Mechanisms of haematopoietic and cardiac patterning remain poorly understood. Here we show that the BMP and Wnt signalling pathways are integrated in an endoglin (Eng)-dependent manner in cardiac and haematopoietic lineage specification. Eng is expressed in early mesoderm and marks both haematopoietic and cardiac progenitors. In the absence of Eng, yolk sacs inappropriately express the cardiac marker, Nkx2.5. Conversely, high levels of Eng in vitro and in vivo increase haematopoiesis and inhibit cardiogenesis.… Show more

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Cited by 18 publications
(32 citation statements)
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“…Different reports point to a cross-talk between Wnt/β-catenin and Tgf-β/Bmp signalling as a basic regulatory mechanism of stem cell function in mammalian tissues; for instance, in the regulation of intestine stem cells proliferation (He et al, 2004;Kühl and Kühl, 2013), epidermal/hair placode fate (Fuchs, 2007), or, more recently, in haematopoiesis, where Eng integrates Bmp and Wnt signalling to induce that process (Baik et al, 2016).…”
Section: Discussionmentioning
confidence: 99%
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“…Different reports point to a cross-talk between Wnt/β-catenin and Tgf-β/Bmp signalling as a basic regulatory mechanism of stem cell function in mammalian tissues; for instance, in the regulation of intestine stem cells proliferation (He et al, 2004;Kühl and Kühl, 2013), epidermal/hair placode fate (Fuchs, 2007), or, more recently, in haematopoiesis, where Eng integrates Bmp and Wnt signalling to induce that process (Baik et al, 2016).…”
Section: Discussionmentioning
confidence: 99%
“…Eng is also involved in skin regeneration during wound healing (Pérez-Gómez et al, 2014) and can supress keratinocyte proliferation in early stages of a multistage mouse skin carcinogenesis model, driving malignant progression, invasion and metastasis, in later phases (Pérez-Gómez et al, 2007;Quintanilla et al, 2003). These observations point to important roles for Eng in the regulation of skin stem cell niches and in the maintenance of skin homeostasis similar to the role of this protein in the hematopoietic system (Baik et al, 2016).…”
Section: Introductionmentioning
confidence: 86%
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“…Before refining the current protocols, studies involving ES cell differentiation focused for many years on lineages that were easily recognized in the culture dish, such as the presence of red blood cells or beating cardiomyocytes [86]. Remarkably, similarly to mouse development, in vitro differentiation of mouse ES cells recapitulate both primitive and definitive hematopoiesis, allowing several investigators to use this system to study transcription factors and signaling pathways involved in early hematopoietic cell fate specification [8789]. …”
Section: Pluripotent Cells As Model To Study Muscle Developmentmentioning
confidence: 99%