“…Different reports point to a cross-talk between Wnt/β-catenin and Tgf-β/Bmp signalling as a basic regulatory mechanism of stem cell function in mammalian tissues; for instance, in the regulation of intestine stem cells proliferation (He et al, 2004;Kühl and Kühl, 2013), epidermal/hair placode fate (Fuchs, 2007), or, more recently, in haematopoiesis, where Eng integrates Bmp and Wnt signalling to induce that process (Baik et al, 2016).…”