Endohyperthermia - Experimental Evaluation of a New Therapeutic Approach for Treatment of Biliary Carcinoma

Weigert, N.; Eckel, Florian; Born, Peter; Erhardt, W.; Henke, J; Werner, Matthias; Claßen, Martin; Rösch, T

doi:10.1055/s-2000-7380

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…Although there are promising primary data, a conclusive assessment of this method is not currently possible. The same applies to the use of local hyperthermia treatment, which is still in the process of development (26).…”

Section: Discussionmentioning

confidence: 93%

Long-term outcome in patients with advanced hilar bile duct tumors undergoing palliative endoscopic or percutaneous drainage

Born¹,

Rösch²,

Brühl³

et al. 2000

Z Gastroenterol

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Section: Discussionmentioning

confidence: 93%

Long-term outcome in patients with advanced hilar bile duct tumors undergoing palliative endoscopic or percutaneous drainage

Born¹,

Rösch²,

Brühl³

et al. 2000

Z Gastroenterol

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“…Other ablative techniques. Intraductal high-intensity ultrasound and endohyperthermia, both of which involve delivery of high energy via an intraductal catheter passed at the time of ERCP, remain investigational techniques [23,24].…”

Section: Therapeutic Interventions Endoscopymentioning

confidence: 99%

Comprehensive review of the diagnosis and treatment of biliary tract cancer 2012. PART II: Multidisciplinary management

Marsh

Alonzo

Bajaj

et al. 2012

Journal of Surgical Oncology

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Biliary tract cancers (gallbladder cancer, intra- and extra-hepatic cholangiocarcinoma and selected periampullary cancers) accounted for 12,760 new cases of cancer in the USA in 2010. These tumors have a dismal prognosis with most patients presenting with advanced disease. Early, accurate diagnosis is essential, both for potential cure where possible and for optimal palliative therapy in all others. This review examines the currently available and emerging technologies for diagnosis and treatment of this group of diseases.

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“…Local hyperthermia targets small lesions using a confined heat source generated with different energy sources, such as radio-frequency (RF), microwave, or ultrasound radiation [13]. For example, an endohyperthermia technique for treatment of biliary carcinoma was reported to use a catheter-like RF applicator inserted into a bile duct to apply heat through RF ablation [14]. Hyperthermia treatment implemented by moderate heating of stents (to temperatures of ∼50°C) was shown to be effective for inhibiting neointimal hyperplasia, the major cause of in-stent restenosis, without increasing thrombosis induction [15].…”

mentioning

confidence: 99%

RF-Powered Stent With Integrated Circuit Breaker for Safeguarded Wireless Hyperthermia Treatment

Luo

Chen

Dahmardeh

et al. 2015

J. Microelectromech. Syst.

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This paper presents a wireless, electrothermally active stent with an integrated temperature limiter toward the application to endohyperthermia treatment of restenosis, a major post-stenting complication. A stent-based resonant circuit serves as a frequency selective wireless heater controlled using a tuned radio-frequency (RF) electromagnetic field radiated externally, applying local thermal stress to the stented site to suppress in-stent restenosis. A biocompatible 1.5 × 2 × 0.6-mm 3 chip of micro circuit breaker with an embedded capacitor is developed and integrated with the stent to establish the resonant circuitry with a series-connected micro breaker. A micromachined shapememory-alloy cantilever serves as a thermoresponsive switch in the chip that opens/closes the circuit depending on the stent temperature, automatically preventing the stent from overheating in a fully passive manner. Wireless heating tests of the prototypes deployed into artificial artery using commercial balloon catheters demonstrate the designed function of the circuit breaker, regulating the stent temperature within 50°C-66°C when excited in air at an output RF power of 320 mW, which heats the device to 78°C without the breaker. Their performance in physiological saline is also tested and discussed in detail. The experimental results validate the device concept and approach toward enabling reliable and safeguarded hyperthermia treatment through wireless stents.[2015-0007]

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Endohyperthermia - Experimental Evaluation of a New Therapeutic Approach for Treatment of Biliary Carcinoma

Abstract: The intraluminal endohyperthermia system produces consistent and repeatable heating of the surrounding tissue. Since effective thermal power can reach a depth of up to 2 cm, tumors may also be heated adequately.

Cited by 9 publications

References 9 publications

Long-term outcome in patients with advanced hilar bile duct tumors undergoing palliative endoscopic or percutaneous drainage

Long-term outcome in patients with advanced hilar bile duct tumors undergoing palliative endoscopic or percutaneous drainage

Comprehensive review of the diagnosis and treatment of biliary tract cancer 2012. PART II: Multidisciplinary management

RF-Powered Stent With Integrated Circuit Breaker for Safeguarded Wireless Hyperthermia Treatment

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