Endometrial Adenocarcinoma Presenting with an Osseous Metastasis

Abstract

Background: Gynecologic cancers metastatic to bone are rare. Endometrial carcinoma usually presents with vaginal bleeding. Case Report: A 67-year-old woman presented with pain, erythema and swelling of the right foot and no history of postmenopausal bleeding. Biopsy revealed primary endometrioid carcinoma metastatic to the calcaneus, talus and metatarsal bones. Lower leg amputation, total abdominal hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node sampling were performed. Postoperatively the patient received cisplatin with adriamycin and megestrol acetate and is alive with no evidence of disease 20 months after the diagnosis. Conclusion: Endometrial carcinoma can present as a metastatic lesion of bone.

Solitary bone metastasis in the tibia as a presenting sign of endometrial adenocarcinoma: a case report and the review of the literature

“…We also treated our patient with radiation, preserved bone intact and obtained good results. As reported by Uharcek et al [24], leg amputation and other therapies (e.g. chemotherapy) had not performed.…”

Bone recurrence rarely seen in endometrial cancer and review of the literature

“…Amputation should be considered if there is uncontrollable pain and serious infection . Uharcek et al and Petru et al described survival after leg amputation and radiotherapy .…”

Bilateral femur metastases in low‐grade endometrial carcinoma

“…In 10 cases, the metastasis was the presenting manifestation of cancer, while in the remaining cases the mean interval from initial diagnosis to bone metastasis was about 3 years (6 months to 5 years) .…”

“…We reviewed the literature and found 32 cases of bone metastases, 18 of which involved the lower limbs . We describe the case of synchronous metastases at both distal femurs from a low‐grade endometrial carcinoma.…”