Endometrial Cancer in Aspect of Forkhead Box Protein Contribution

Adamczyk-Gruszka, Olga; Horecka-Lewitowicz, Agata; Gruszka, Jakub; Wawszczak-Kasza, Monika; Strzelecka, Agnieszka; Lewitowicz, Piotr

doi:10.3390/ijerph191610403

Cited by 2 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These tumors are characterized by low malignancy and generally favorable prognosis. Distinguishing them from endometrial carcinomas is essential because the latter tend to occur in older patients and are aggressive malignancies [1,19].…”

Section: Risk Factors Of Endometrial Cancermentioning

confidence: 99%

A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging

Adamczyk-Gruszka

2023

View full text Add to dashboard Cite

Endometrial cancer is the most common cancer of the female genital organs. For many years the prognosis was based on histopathological grade and type. The pathological identification of endometrial carcinomas included two types. Type Iendometrioid (EEC), similar to the endometrium -was characterized by genetic predisposition, obesity, polycystic ovary syndrome, anovulatory cycles, and irregular menstruation resulting from hyperestrogenism, which is the main predisposing factor for the development of type I EC. Type II included serous, clear cell, and undifferentiated carcinomas. Here were observed older patient's age, higher clinical stage to compare with non-endometrioid histology, and finally poorer prognosis. The Cancer Genome Atlas (TCGA) study found mutations in several endometrioid and serous cancer genes. The TCGA has identified four molecular subclasses based on somatic mutation burden and copy number variations. Recent data show the prognostic value of TCGA subclasses because they correlate with patient survival. StreszczenieRak endometrium jest najczęściej występującym nowotworem żeńskich narządów płciowych. Przez wiele lat podstawą rokowania był stopień dojrzałości histologicznej i typ histopatologiczny. Patologiczna identyfikacja raków endometrium obejmowała jego dwa typy. Typ I -endometrioidalny (EEC), podobny do endometrium, charakteryzuje się predyspozycjami genetycznymi, otyłością, zespołem policystycznych jajników, cyklami bezowulacyjnymi, nieregularnymi miesiączkami wynikającymi z hiperestrogenizmu, który jest głównym czynnikiem predysponującym do rozwoju EC typu I. Do typu II zaliczono: raki surowicze, jasnokomórkowe i niezróżnicowane. Zaobserwowano tu starszy wiek pacjentek, wyższy stopień zaawansowania klinicznego w porównaniu z histologią nieendometrioidalną, a także gorsze rokowanie. Badanie Cancer Genome Atlas (TCGA) wykazało mutacje w kilku genach raka endometrioidalnego i surowiczego. TCGA zidentyfikowała cztery podklasy molekularne na podstawie obciążenia mutacjami somatycznymi i zmienności liczby kopii. Najnowsze dane wskazują na wartość prognostyczną TCGA, ponieważ korelują one z przeżyciem pacjentów.

show abstract

Section: Risk Factors Of Endometrial Cancermentioning

confidence: 99%

A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging

Adamczyk-Gruszka

2023

View full text Add to dashboard Cite

show abstract

FGFR-2 and Epithelial–Mesenchymal Transition in Endometrial Cancer

Adamczyk-Gruszka

Horecka-Lewitowicz

Gruszka

et al. 2022

JCM

View full text Add to dashboard Cite

Background. At present, EC staging is based on the WHO conservative criteria, which only consider the percentage of gland formation. The molecular subgrouping of EC recently proposed by the Cancer Genome Atlas (TCGA) represents a milestone in precise molecular-based patient triage. The present study aimed to investigate the influence of FGFR-2 on the epithelial–mesenchymal transition (EMT) and whether it can lead to endometrial cancer dedifferentiation. Methods. One hundred and three White female patients with confirmed EC were enrolled in our research. For the analysis, we performed next-generation sequencing and immunohistochemical analyses of E-cadherin, β-catenin, and vimentin. Results. Tumor grade progression was closely correlated with LVI (p = 0.0338), expression of vimentin (p = 0.000), tumor budding (p = 0.000), and lack of E-cadherin (p = 0.0028). Similar observations were noted with regard to TNM/FIGO stage progression. In terms of FGFR-2 mutation, we found the following correlation p-values: LVI (p = 0.069), expression of vimentin (p = 0.000), tumor budding (p = 0.000), and lack of E-cadherin (p = 0.000), RFS (p = 0.032), ECSS (p = 0.047). Conclusions. FGFR-2 is the important factor influencing on EMT.

show abstract

Endometrial Cancer in Aspect of Forkhead Box Protein Contribution

Cited by 2 publications

References 28 publications

A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging

A new approach to endometrial cancer subtyping – a hope for a milestone in correct patient triaging

FGFR-2 and Epithelial–Mesenchymal Transition in Endometrial Cancer

Contact Info

Product

Resources

About