Endometrial expression of progesterone, estrogen, and oxytocin receptors and of 20α-hydroxysteroid dehydrogenase and cyclooxygenase II 2 and 5 days after ovulation in induced short and normal estrous cycles in dairy cows

Rantala, Mari H.; Mutikainen, Mervi; Schuler, Gerhard; Katila, Terttu; Taponen, Juhani

doi:10.1016/j.theriogenology.2014.01.024

Cited by 12 publications

(6 citation statements)

References 36 publications

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“…In cattle, the increase of plasma E2 concentration was observed between three-and nine-days post-estrus. This E2 peak is smaller than that of the follicular phase [7,10,25].…”

Section: Introductionmentioning

confidence: 67%

Possible roles of local oviductal estradiol-17β in luteal formation phase on the function of bovine oviductal epithelium

Hazano

Haneda

Kayano

et al. 2019

The Journal of Veterinary Medical Science

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Oviducts play an important role in the reproductive process, such as in gamete transport, fertilization, and early embryonic development. However, the regulation of oviductal function during 4−5 days post-ovulation (luteal formation phase), which is a crucial phase for early embryonic development, remains poorly understood. This study investigated the roles of oviductal estradiol-17 (E2) and progesterone (P4) concentrations on bovine oviductal functions during the luteal formation phase using RT-qPCR for some genes of oviductal epithelial cells. Bovine oviducts ipsilateral to the corpus luteum (CL) in the luteal formation phase were collected from a slaughterhouse. The concentration of oviductal E2 was positively correlated with the mRNA expressions of nuclear P4 receptor (PGR) and protein disulfide isomerase family A member 4 (PDIA4), which is related to protein secretion, in the ampulla and with estrogen receptor α (ESR1) mRNA expression in the isthmus. In contrast, the concentration of oviductal P4 was not correlated with oviductal mRNA expressions in either regions. Furthermore, for the candidate factor related to the oviductal E2 concentration, the CL parameters (CL size and tissue P4 concentration), first-wave dominant follicle (W1DF) parameters (follicle size and intrafollicular E2 concentration), and W1DF location (ipsilateral or contralateral to CL) did not influence the oviductal E2 concentration. In conclusion, our results suggest that the local oviductal E2 is a potential oviductal function regulator during the luteal formation phase.

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“…In cattle, the increase of plasma E2 concentration was observed between three-and nine-days post-estrus. This E2 peak is smaller than that of the follicular phase [7,10,25].…”

Section: Introductionmentioning

confidence: 67%

Possible roles of local oviductal estradiol-17β in luteal formation phase on the function of bovine oviductal epithelium

Hazano

Haneda

Kayano

et al. 2019

The Journal of Veterinary Medical Science

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“…In veterinary medicine, it has been used for the pathological diagnosis of endometritis in cows for more than 40 years (McQueen 1967). The existing collection of bovine endometrium using biopsy forceps (Rantala et al 2014), endoscope instruments, or a cytobrush (Kasimanickam et al 2014) was recently used for physiological analysis by tissue culture and gene expression analysis, as well as pathological diagnosis. As endometrial biopsy is conducted on live cows and collected repeatedly during the estrous cycle, it is the most suitable method of bovine reproduction (Chapwanya et al 2010).…”

Section: Biopsymentioning

confidence: 99%

Possibility of Diagnosing Uterine Function in Cows

Iga

Takenouchi

Shimizu

et al. 2016

JARQ

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Declining in reproductive efficiency is a worldwide problem, although remarkable progress has been made in reproductive techniques including artificial insemination programs, estrous cycle synchronization, and effective embryo production. One means of solving this problem is to select breeding cows based on highly precise diagnosis for high reproductive ability, including ovarian and uterine function. Many recent studies have documented the regulation of uterine function, with the results suggesting that said functions might be an effective diagnostic index for reproductive performance. Therefore, the production of oxytocin-induced prostaglandin F2α and epidermal growth factor in bovine endometrium, such as the physiological reaction in vivo, may be useful in detecting repeat breeder cows. Although the diagnosis is possible using relatively simple techniques such as biopsy, culture, and hormone assay, it is difficult to apply such diagnosis to the field conditions. However, further improvements in the exhaustive gene expression analysis of uterine function in repeat breeder or low fertility cows, so as to determine the genes associated with physiological reactions, could lead to new diagnostic indexes resulting in improved reproductive efficiency.

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“…A previously described and validated RIA was used to determine the serum concentration of E 2 (Rantala et al, 2014).…”

Section: Endocrine Analysesmentioning

confidence: 99%

The somatotropic axis during the physiological estrus cycle in dairy heifers—Effect on hepatic expression of GHR and SOCS2

Mense

Meyerholz

Araujo

et al. 2015

Journal of Dairy Science

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Pituitary growth hormone (GH) release and hepatic insulin-like growth factor-I (IGF-I) production increase after an injection of 17β-estradiol (E2) in ovariectomized dairy cattle. However, whether endogenous sexual steroid hormones also influence the hepatic GH receptor (GHR) signaling pathway during a physiological estrus cycle remains unclear. The aim of this study was to analyze the hepatic GHR signaling pathway during the luteal phase and after a period of increased E2 concentrations (after ovulation) as well as in 7 heifers before ovulation. Ovarian ultrasounds were performed daily during repeated physiological cycles (n = 56) of 30 Holstein Friesian heifers to determine ovulation [before ovulation (n = 7, bOv) and after ovulation 24-60 h after the appearance of estrus signs (n = 49, aOv)] and luteal phase (CLP; d 12 ± 1 after ovulation). Blood samples and liver biopsies were obtained, and blood concentrations of E2, P4, insulin-like growth factor (IGF)-I, IGF-II, and GH were measured. In the liver biopsies, we determined mRNA expression of the estrogen receptor α (ERα), GHR, Janus kinase 2 (JAK2), signal transducer and activator of transcription 5B (STAT5B), suppressor of cytokine signaling (SOCS)2 and 3, IGF-I, and IGF-II by quantitative reverse transcription-PCR. The concentration of E2 was higher bOv than aOv and CLP, as expected. The concentrations of IGF-I and GH were higher bOv and aOv compared with CLP. In contrast, concentrations of IGF-II were lower aOv compared with bOv and CLP. The mRNA expression of GHR was higher in liver biopsies obtained bOv compared with aOv and CLP. Notably, the expression of SOCS2 was higher bOv than aOv and in the CLP. Increased hepatic expression of SOCS2 during estrus was detectable when IGF-I concentrations were high; this result might indicate that SOCS2 expression attenuates the GHR signal transduction pathway during the phase of increased pituitary GH release. In conclusion, hepatic GHR and SOCS2 mRNA expression appeared to be promptly and sensitively regulated by increased E2 levels before ovulation of dairy heifers.

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Endometrial expression of progesterone, estrogen, and oxytocin receptors and of 20α-hydroxysteroid dehydrogenase and cyclooxygenase II 2 and 5 days after ovulation in induced short and normal estrous cycles in dairy cows

Cited by 12 publications

References 36 publications

Possible roles of local oviductal estradiol-17β in luteal formation phase on the function of bovine oviductal epithelium

Possible roles of local oviductal estradiol-17β in luteal formation phase on the function of bovine oviductal epithelium

Possibility of Diagnosing Uterine Function in Cows

The somatotropic axis during the physiological estrus cycle in dairy heifers—Effect on hepatic expression of GHR and SOCS2

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