Endometrial hyperplasia: Value of endometrial thickness in ultrasonographic diagnosis and clinical significance

Abstract

The records of 90 patients with histologically proven endometrial hyperplasia (EH) were reviewed retrospectively. Eleven of these patients had pelvic ultrasound examinations available. These were compared to the pelvic ultrasound examinations of 19 patients with a histologically normal endometrium, available in 126 consecutive patients seen over the same period of time. Patients with EH had a mean endometrial thickness of 18.8 mm (range 8 mm to 45 mm) vs 5.4 mm (range 2 mm to 10 mm) in the control group. This difference in thickness was statistically significant (p much less than .01). The specificity and sensitivity of endometrial thickness in the diagnosis of EH were 100% and 81%, respectively, when 10 mm was taken as the upper limit of normal. Ultrasonographically demonstrable endometrial characteristics can differentiate EH from normal endometrium in a great majority of cases. The clinicopathological significance of EH is discussed.

Transvaginal Ultrasonographic Evaluation of the Endometrium Related to the Histological Findings in Pre- and Perimenopausal Women

“…These bleedings, often resistant to conservative therapy, are often caused by endometrial hyperplasia or polyps. Endometrial hyperplasia is an important pathological condition and was found in 12% of our patients which compares well with other studies [4,6,22]. Endometrial hyperplasia cannot be seen as a simple entity pathologically, as it exhibits a spectrum of findings that makes it difficult to classify [23].…”

“…Endometrial hyperplasia cannot be seen as a simple entity pathologically, as it exhibits a spectrum of findings that makes it difficult to classify [23]. There is a continuum of endometrial changes from glandular atypia to obvious neoplasm [22,[24][25][26]. How often and how fast these changes take place had been discussed.…”

Endovaginal Ultrasound to Exclude Endometrial Cancer and Other Endometrial Abnormalities

“…Studies that prospectively evaluated EVUS on patients prior to obtaining endometrial tissue (endometrial biopsy, dilatation and curettage, or hysterectomy) were included. Retrospective studies, 19,33,34,62,72,77 studies with selective histological sampling, 23,24,29,39,52,62,69 studies that reported results pooled for premenopausal and postmenopausal women, 42,71,84,97 and studies that measured endometrial thickness following tissue sampling 13,17,23,42,49,58,62 were excluded. In addition, studies that evaluated EVUS only in asymptomatic women, 16,35,67,69,81,93,98,99 women receiving tamoxifen, 31,32,51,56,59,75 and women with known endometrial cancer 43,58,100,101 ; studies not reporting endovaginal thickness measurements 15,26,52,71,72,74,76,77 ; and studies where the crude data could not be extracted 19,21,24,39,42,…”

Predictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age

“…A limit of M-echo thickness at 8 mm [47] or 10 mm [48] was suggested for this category of patients, as the upper limit for normal thickness was also suggested on a value of 9 mm in women receiving treatments associated with thicker endometria (estrogen alone and cyclical combinations) [49-51]. …”