Endometrial Morphology and Peripheral Hormone Levels in Women with Regular Menstrual Cycles

Johannisson, E.; Landgren, Britt-Marie; Rohr, H. P.; Diczfalusy, E.

doi:10.1097/00006254-198843040-00017

Cited by 4 publications

(5 citation statements)

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“…These events are characterized by an increase in endometrial capillary dilation, permeability, stromal edema, blood flow, leucocyte number and secretion of pro-inflammatory factors (Fraser et al ., 1987; Johannisson et al ., 1987; Peek et al ., 1992). Pro-inflammatory enzymes PTGS1 and PTGS2 are key mediators of these inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

“…The expression of the prostanoid receptors PTGER2, 3 and 4 peaked during the mid-secretory phase. The increased expression of these receptors coincides with increased stromal oedema, blood vessel permeability and endometrial blood flow in the human endometrium (Fraser et al ., 1987; Johannisson et al ., 1987; Peek et al ., 1992). Evidence supporting a role for PGE 2 receptors in these events is demonstrated by infusion of PGE 2 into rodent uteri which has been shown to increase uterine vascular permeability, uterine extracellular fluid volume (Hamilton and Kennedy, 1994) and act as an immunomodulator inhibiting lytic activation of maternal leucocytes (Parhar et al ., 1989).…”

Section: Discussionmentioning

confidence: 99%

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Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle

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Wilson

Boddy

et al. 2010

Molecular Human Reproduction

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Prostanoids are well-described primary mediators of inflammatory processes and are essential for the normal physiological function of the female reproductive system. The aim of this study was to determine the temporal expression of the prostanoid biosynthetic enzymes (PTGS1, PTGS2, PTGES, PTGES2, PTGES3, AKR1B1, AKR1C3, CBR1, HPGDS, PTGDS, PTGIS, TBXAS1 and HPGD) and the prostanoid receptors (PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGDR, GPR44, PTGIR and TBXA2R) in the human endometrium throughout the menstrual cycle. The analysis identified PTGFR to have a distinct expression profile compared with other components of the prostanoid system, as expression is maximal during the proliferative phase. Immunohistochemical analysis for PTGER1 suggests a dual function for this receptor depending on its temporal (proliferative versus secretory) and spatial (nuclear versus cell membrane) expression. The expression profiles of the PGF2α synthases identified AKR1B1 and CBR1 as the likely regulators of PGF2α production during the menstrual phase. Immunohistochemical analysis for AKR1B1, CBR1 and AKR1C3 suggest expression to be in the glandular epithelium and vasculature. This study represents the first comprehensive analysis of the components of prostanoid biosynthetic and signalling pathway in the human endometrium. The expression profiles described have the potential to identify specific prostanoid components that may be dysregulated in inflammatory-associated disorders of the endometrium.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle

Catalano

Wilson

Boddy

et al. 2010

Molecular Human Reproduction

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“…The day of the luteinizing hormone (LH) surge was estimated by using a self-test detecting urinary LH (Clearplan; Searle Unipath, Bedford, United Kingdom) twice daily from cycle day 10 to the LH peak.The results of this test have been proven to correlate well with the LH surge determined from peripheral blood. 14 The days of biopsy were selected in relation to the day of the LH surge, LH+0. For fertile women, a single biopsy was taken at 1 point during the menstrual cycle.…”

Section: Menstrual Cycle Monitoringmentioning

confidence: 99%

HB-EGF but Not Amphiregulin or Their Receptors HER1 and HER4 Is Altered in Endometrium of Women With Unexplained Infertility

et al. 2008

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Heparin-binding epidermal growth factor-like growth factor (HB-EGF) and its receptors (HER1 and HER4) play a role in the human implantation process. Amphiregulin is a member of the EGF family but with unknown function in human fertility. It has been suggested that some women with unexplained infertility have defective endometrial development. The aim of this study is to determine the presence of amphiregulin and the receptors HER1 and HER4 in normal human endometrium throughout the menstrual cycle. In addition, the present study aims to compare endometrium from women with unexplained infertility with endometrium from women with male factor infertility and healthy fertile controls. Immunohistochemistry and real-time polymerase chain reaction were used to determine the expression of HB-EGF, HER1, HER4, and amphiregulin. The stromal staining of HER1 and the epithelial staining of HER4 were most intense in the mid- and late-secretory-phase endometrium. Amphiregulin did not vary during the menstrual cycle. In the mid-secretory phase, the protein expression of HB-EGF was lower in endometrium from women with unexplained infertility versus normal endometrium and endometrium from women with male factor infertility. HB-EGF and HER4 mRNA expression in mid-secretory endometrium of women with unexplained and male factor infertility were increased compared with normal controls. Impaired endometrial expression of certain members of the EGF family may contribute to infertility in some women with unexplained infertility.

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“…The time-point in the menstrual cycle at which the biopsy had been taken can be determined by different methods, e.g. by histological dating (135,136) or by recording the day of luteinising hormone (LH) surge (125). The implantation window corresponds to day 5 to day 10 after the LH surge (38).…”

Section: Human Endometrial Explant Culturementioning

confidence: 99%

In Vitro Tests for Detecting Chemicals Affecting the Embryo Implantation Process

et al. 2007

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This is the report of the 62nd of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences, and which reduce, refine or replace the use of laboratory animals. One of the first priorities set by ECVAM was the implementation of procedures that would enable it to become well informed about the state of the art of non-animal test development and validation, and of opportunities for the possible incorporation of alternative methods into regulatory procedures. It was decided that this would be best achieved through a programme of ECVAM workshops, each addressing a specific topic, and at which selected groups of independent international experts would review the current status of various types of in vitro tests and their potential uses, and make recommendations about the best ways forward (1).

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Endometrial Morphology and Peripheral Hormone Levels in Women with Regular Menstrual Cycles

Cited by 4 publications

References 0 publications

Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle

Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle

HB-EGF but Not Amphiregulin or Their Receptors HER1 and HER4 Is Altered in Endometrium of Women With Unexplained Infertility

In Vitro Tests for Detecting Chemicals Affecting the Embryo Implantation Process

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