Endometrial morphology in asymptomatic postmenopausal women

Archer, David F.; McIntyre‐Seltman, Kathleen; Wilborn, Walter; Dowling, Edmond A.; Cone, Frederick L.; Creasy, George W.; Kafrissen, Michael E.

doi:10.1016/0002-9378(91)90084-5

Cited by 144 publications

(50 citation statements)

References 5 publications

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“…A similar trend was also shown by the non-neoplastic atrophic endometrium, adjacent to endometrial carcinoma. Earlier Archer and colleagues 8 and Korhonem et al 9 investigating endometrial patterns in asymptomatic postmenopausal women, found a similar proliferative activity in approximately 25% of the cases studied and hyperplastic disease is less than 5%. Although all postmenopausal endometria, whether active or inactive , retain full ER and PR complement, as shown in the some studies, only those showing a weak proliferative activity, which are EGFR positive and with a high angiogenic and proliferative (Ki-67) activity, show a low potential for giving rise to endometrial adenocarcinoma.…”

Section: Association Between Atrophic and Malignant Endometria With mentioning

confidence: 66%

A study of expression of estrogen and progesterone receptor, in atrophic, hyperplastic and malignant endometrial lesions, with emphasis on relationship with prognostic parameters

et al. 2015

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Section: Association Between Atrophic and Malignant Endometria With mentioning

confidence: 66%

A study of expression of estrogen and progesterone receptor, in atrophic, hyperplastic and malignant endometrial lesions, with emphasis on relationship with prognostic parameters

et al. 2015

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“…Atrophic endometrium was seen predominantly in post-menopausal age group due to absence of estrogenic stimulation leading to thin atrophic endometrium susceptible to minor injury [19]. Lidor (45%) [20] and Gredmark (50%) [21] studied that atrophic endometrium was the most common cause of post-menopausal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Spectrum of Endometrial Changes in Peri-menopausal and Post-menopausal Abnormal Uterine Bleeding: A 2 Years Study

Damle

Dravid

Suryawanshi

et al. 2013

JCDR

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Background: Abnormal uterine bleeding is the Common pre senting complaint in Gynaecology Outpatient Department in all age groups. It is due to the anovulatory cycles which are commonly seen in adolescent and perimenopausal women. Abnormal uterine bleeding is caused by wide variety of organic or nonorganic causes. Histopathological examination of endometrial sample remains the gold standard for diagnosis of endometrial pathology.

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“…3 mm) [9][10][11] . It has been reported that the detection rate of endometrial diseases is much lower in asymptomatic cases than in symptomatic ones [5,16,17] . From these fi ndings, we believe that few endometrial disease cases were missed in our study.…”

Section: Discussionmentioning

confidence: 99%

“…In postmenopausal Japanese women without genital bleeding in our series, 0.9% had endometrial cancer and 1.4% endometrial hyperplasia. The prevalence of endometrial cancer and endometrial hyperplasia in asymptomatic postmenopausal women has been reported to be 0.1-0.7 and 0.5-0.6% [5,16,17] . In our series, the prevalence of endometrial diseases in postmenopausal Japanese women was slightly higher than that in previous reports.…”

Section: Discussionmentioning

confidence: 99%

Transvaginal Ultrasonography of the Endometrium in Postmenopausal Japanese Women

Tsuda

Nakamura

Inoue

et al. 2005

Gynecol Obstet Invest

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Aims: To determine the cut-off level of endometrial thickness for detecting endometrial disease on a large scale of screening and to examine the usefulness of transvaginal ultrasonography (TVS) for endometrial disease screening in asymptomatic postmenopausal Japanese women. Methods: The study involved 1,400 postmenopausal women in whom endometrial thickness was measured with TVS, and then compared with the histopathological diagnosis of endometrial specimens. Results: The prevalence of endometrial disease in asymptomatic and symptomatic cases was 2.3 and 21%. In symptomatic cases, at a cut-off limit of 3 mm for endometrial thickness, the sensitivity for detecting endometrial disease was 94%, specificity 70% and positive predictive value 46%. With an endometrial thickness ≤3 mm, the probability that endometrial disease would be overlooked was 0.025.In asymptomatic cases, the corresponding figures at a cut-off limit of 3 mm were 90, 84, 12% and 0.003. Conclusions: TVS does not appear to be an effective screening method in asymptomatic postmenopausal Japanese women because of the low prevalence of endometrial disease in this population. We recommend a normal cut-off level for endometrial thickness of 4 mm in symptomatic postmenopausal Japanese women.

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Endometrial morphology in asymptomatic postmenopausal women

Cited by 144 publications

References 5 publications

A study of expression of estrogen and progesterone receptor, in atrophic, hyperplastic and malignant endometrial lesions, with emphasis on relationship with prognostic parameters

A study of expression of estrogen and progesterone receptor, in atrophic, hyperplastic and malignant endometrial lesions, with emphasis on relationship with prognostic parameters

Clinicopathological Spectrum of Endometrial Changes in Peri-menopausal and Post-menopausal Abnormal Uterine Bleeding: A 2 Years Study

Transvaginal Ultrasonography of the Endometrium in Postmenopausal Japanese Women

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