Endometrial osseous metaplasia: Case report with literature review

Sb, Patil; Narchal, Shilpa; Paricharak, DG; More, SS

doi:10.4103/2141-9248.121209

Cited by 21 publications

(29 citation statements)

References 8 publications

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“…After thorough search of literature we could find very few cases in which patient presented with menstrual complaints. Fawad S reported a case in which patient presented with menometrorrhagia [6] and other cases as reported by Muzaffar M et al, [13] and Patil SB et al, [5] in which patient presented with polymenorrhagia. The indexed case is also a rare occurrence as the patient presented with menorrhagia.…”

Section: Discussionmentioning

confidence: 89%

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Endometrial Osseous Metaplasia—A Rare Presentation of Polymenorrhagia: A Case Report

Nigar¹

2015

JCDR

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A 41-year-old female presented to the gynecology outpatient department with a history of continuous, excessive bleeding, lower abdominal pain and vaginal discharge for the past two years. She was multiparous and had delivered two children, both vaginally. The last delivery was 14 years back. The patient gave history of dilatation and curettage at 6 weeks of gestation for incomplete abortion, approximately three and a half years back. Despite conventional hormone therapy, the patient was not relieved. She had no other relevant history suggestive of any systemic disorder. On general examination, she appeared normal except mild pallor was observed. Bimanual examination revealed bulky uterus with mild bilateral tenderness. Ultrasound of pelvis revealed presence of hyper echoic foci measuring 9mm and 15×10mm in the uterine cavity [Table/ Fig-1]. So, dilatation and curettage was done. During curettage gritty sensation was felt and only scanty tissue was removed and it was subjected to histopathological examination. The report revealed chronic endometritis. The decision for hysterectomy was taken since there was no response to the previous treatment and she had no desire of having more children. Obstetrics and Gynaecology SectionEndometrial Osseous Metaplasia-A Rare Presentation of Polymenorrhagia:A Case Report ABSTRACTEndometrial ossification is a rare entity in which bones are found in the uterus. Exact aetiopathogenesis is not known but the most accepted theory is metaplasia of stromal cells into osteoblast cells result in the formation of bones. The possibility of malignant mixed mullerian tumour should be in the mind of clinician and pathologist while making diagnosis. We hereby report an extremely rare case, which is among very few reported cases in the world, in which endometrial ossification presented in a perimenopausal female with polymenorrhagia.A 41-year-old multiparous patient presented with irregular bleeding per vaginum for the past two years. She was found to be a case of endometrial calcification with osseous metaplasia with presence of bones varying from 7mm -1.5 cms size in the uterine cavity. She was successfully managed by total abdominal hysterectomy.On cut section, uterus showed 3 bony fragments of approx.

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Section: Discussionmentioning

confidence: 89%

“…Most of the cases presented with infertility with prior history of abortion [1][2][3][4]. Three cases reported with menstrual irregularities alone [5,6]. Other sites of ossification are vagina [7], cervix [8] and ovary [9].…”

Section: Discussionmentioning

confidence: 99%

Endometrial Osseous Metaplasia—A Rare Presentation of Polymenorrhagia: A Case Report

Nigar¹

2015

JCDR

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“…Nonetheless, it is worth noting that the retention of fetal tissue can possibly lead to OM of the uterus through chronic inflammation. This inflammation then acts as a stimulator of proliferation of mesenchymal cells that have inherent property of metaplasia and can differentiate into chondroblasts or osteoblasts [ 22 ]. In the present case, OM is limited to the cervix as evidenced by the normal echogenicity of the uterus on ultrasound.…”

Section: Discussionmentioning

confidence: 99%

Osseous Metaplasia of the Cervix: A Rare Transformation Can Mimic a Tumor—Literature Review

Alsaqobi

Al-Brahim

2018

Case Reports in Pathology

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Background The transformation of nonosseous soft tissue into bone is known as osseous metaplasia (OM). This condition most commonly affects the musculoskeletal and central nervous systems and it is a well-known phenomenon in different soft tissue organs. Rarely, OM can affect the uterus, which can extend into the cervix. OM affecting the cervix alone is a more rare condition that has multiple different clinical presentations. The presentation can be similar to that of a tumor in extremely rare cases. Case Summary A 23-year-old nulligravida was complaining of irregular vaginal bleeding for one-month duration. Speculum examination revealed a foul-smelling bloody purulent discharge, tender cervix, and a brownish growth located at the posterior cervical lip. A punch biopsy of the growth was performed. Histological examination of the tissue revealed multiple bone fragments with necrosis and an inflammatory exudate. Because of the unusual findings, a repeat biopsy was performed. The biopsy yielded the same findings, which confirmed the diagnosis of osseous metaplasia of the cervix. Conclusion Although osseous metaplasia is a known phenomenon in different soft tissues, it is extremely rare in the uterine cervix and can mimic malignancy. Therefore, clinicians should be aware of it.

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“…Endometrial stromal metaplasia includes the formation of nests of smooth muscle, cartilage and bone in the endometrial stroma [4]. The newest World Health Association (WHO) classification divides them into cases with epithelial and cases with nonepithelial changes.…”

Section: Discussionmentioning

confidence: 99%

Endometrial osseous metaplasia: Presentation of two rare cases related with infertility, and their hysteroscopic approaching

et al. 2017

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Objective: To present two cases of patients diagnosed of endometrial osseous metaplasia related with infertility and their hysteroscopic approaching.Design: Case report. Results: Both patients underwent a diagnostic hysteroscopy, and removal of all the bone fragments with total resolution of their pathology. Setting: Conclusions:Endometrial osseous metaplasia is a rare pathology that should be suspected in patients with a history of secondary in-

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Endometrial osseous metaplasia: Case report with literature review

Cited by 21 publications

References 8 publications

Endometrial Osseous Metaplasia—A Rare Presentation of Polymenorrhagia: A Case Report

Endometrial Osseous Metaplasia—A Rare Presentation of Polymenorrhagia: A Case Report

Osseous Metaplasia of the Cervix: A Rare Transformation Can Mimic a Tumor—Literature Review

Endometrial osseous metaplasia: Presentation of two rare cases related with infertility, and their hysteroscopic approaching

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