Endometrial Receptivity and Scoring for Prediction of Implantation and Newer Markers

Malhotra, Narendra; Singh, Amreen; Gupta, Pallavi

doi:10.5005/jp-journals-10006-1481

Cited by 7 publications

(13 citation statements)

References 32 publications

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“…Blood flow to the endometrium as well as the uterine biophysical profile can be measured via a combination between abdominal and transvaginal ultrasound. Greater blood flow to the uterus has been associated with higher implantation rates and can be seen in color utilizing Doppler ultrasound methods [27]. PRP infusion has the potential to increase lining development as well as endometrial vascularity as proven by Tandulwadkar, and future studies should observe an increase in vascularity concordant with lining and uterine biophysical profile.…”

Section: Discussionmentioning

confidence: 98%

“…After ovulation, the endometrium is exposed to progesterone which induces morphological and biochemical changes that alter the endometrium from the proliferative phase to the secretory phase [17]. In HRT cycles, estradiol administration (typically Estradiol Valerate) occurs until the lining has reached a thickness of greater than 7 mm, at which time progesterone is then administered for the number of days proportional to the embryo being transferred (i.e., a day 6 blastocyst will receive progesterone for 6 days) and then the embryo is transferred to a supposedly receptive endometrium [26,27]. In these HRT cycles, patients receive estradiol during the follicular phase that inhibits gonadotropin secretion and prevents follicular development and ovulation.…”

Section: Hormone Replacement Therapymentioning

confidence: 99%

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Autologous Platelet-Rich Plasma Infusion to Improve Pregnancy Outcome in Suboptimal Endometrium: A Review

Zeffiro¹,

Bocca²,

Russell³

et al. 2020

Innovations in Assisted Reproduction Technology

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Over the past decade, platelet-rich plasma (PRP) has been used in several fields of medicine to promote cell growth and expedite wound healing for the treatment of arthritis, nerve injury, tendinitis, bone regeneration, cardiac muscle repair, and oral & plastic surgery. Recently, researchers have been applying autologous PRP to bolster the growth of endometrial lining in patients with a history of endometriumrelated failed embryo transfers. Evidence reveals that PRP is a rich source of active cytokines and various growth factors, which come from an autologous source that can be easily attained from peripheral blood without risk of disease transmission to the patient. In this review, several studies were analyzed that involved patients 18-42 years of age undergoing hormone replacement therapy (HRT) in preparation for embryo transfer and serial transvaginal ultrasound in conjunction with PRP infusions into the endometrium via an intrauterine insemination (IUI) catheter. Exclusion criteria included patients with endometritis, polyps, or adhesions. Embryo transfers (ET) were performed when the endometrial lining achieved a thickness of >7 mm. The database indicates that PRP infusion therapy is a promising low-cost treatment for HRT patients that significantly increases endometrial thickness and improves pregnancy success in a previous suboptimal ET patient population.Evidence shows that PRP infusion directly into the endometrium enhances lining development in patients suffering from chronically refractive or underdeveloped endometrium. Chemical pregnancy in patients that underwent PRP infusion with frozen embryo transfer was 50% (108/216) in comparison to 17.1% (16/93) in patients that did not receive PRP treatment. Innovations in Assisted Reproduction Technology 2Autologous

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Section: Discussionmentioning

confidence: 98%

Section: Hormone Replacement Therapymentioning

confidence: 99%

Autologous Platelet-Rich Plasma Infusion to Improve Pregnancy Outcome in Suboptimal Endometrium: A Review

Zeffiro¹,

Bocca²,

Russell³

et al. 2020

Innovations in Assisted Reproduction Technology

View full text Add to dashboard Cite

show abstract

“…These alterations in treatment protocol need further research to determine effectiveness. 21,22 conclusIon Assessment of change in ET from the day of starting progesterone to the day of embryo transfer, along with the endometrial/subendometrial vascularity, is essential for better pregnancy rates. Women with endometrial compaction and good endometrial vascularity achieved significantly higher CPR than those with poor vascularity.…”

Section: Discussionmentioning

confidence: 99%

Endometrial Compaction in Response to Progesterone Administration and Good Endometrial Vascularity Improves the Clinical Pregnancy Rates in Hormone Replacement Frozen Embryo Transfers

Adiga¹,

Mundkur²,

Sharma³

et al. 2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Purpose:The current study assessed the effect of endometrial compaction and vascularity on clinical pregnancy rates (CPR) in women undergoing frozen embryo transfer (FET). Methods: Prospective observational study. Endometrial compaction and its vascularity were studied by transvaginal ultrasound (TVS) and evaluated CPR. Results: Out of 156 women, 81 had endometrial compaction, 64 had no change in the endometrium, and 11 had an increase in endometrial thickness (ET). Clinical pregnancy rate was 58% among those with endometrial compaction compared to 20.3% among those with no change in ET and 9.1% among those with an increase in ET on the day of FET (p-value < 0.001). Women with 5-10% endometrial compaction, CPR was 61.24%, those with 11-15% compaction had the highest pregnancy rate of 88.2%, and those with compaction of >15% had CPR of 66.6%. Endometrial compaction with zone 3 vascularity had a CPR of 64.2%, and those with zone 4 had 91.7% CPR compared to those with zone 2 vascularity (12.5%), p-value < 0.001. There was poor CPR in women with an increase in ET, though the endometrial vascularity was good. Conclusion: A significant increase in CPR was observed in women who had endometrial compaction with good vascularity of the endometrium, unlike those with poor vascularity. Women with no change or increase in ET had poor pregnancy rates. Hence, assessing the endometrium on the day of starting progesterone and on the day of embryo transfer is essential. If the endometrial compaction has not occurred and/or the endometrial vascularity is poor, the cycle should be considered for cancellation. Clinical significance: Endometrial compaction and good endometrial vascularity are essential for embryo implantation in FET cycles.

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“…Development of the ideally receptive trilaminar endometrial lining >8 mm on imaging is indicative of an optimally primed lining for implantation due to its prominent outer and central hyperechogenic line and inner hypoechogenic black region [11].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Supplementation and Endometrial Lining: Examining the Role and Pathophysiology of Use During Frozen-Thawed Embryo Transfer

O'Connell¹,

Abdalla²,

Radulovich³

et al. 2021

Cureus

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Curcumin is a commonly used herbal supplement purported for its antioxidant, anti-inflammatory, and antineoplastic properties. The effects of curcumin supplementation on endometrial lining have been proposed; however, endometrial preparation in the case of frozen-thawed embryo transfer (FET) has not been established. This case series references two scenarios where turmeric was ingested by the patient, and endometrial thickness was subsequently reduced disrupting the FET cycle. Throughout this case series, curcumin's possible interactions with the uterine lining are summarized. Additionally, these cases highlight the importance of physicians' awareness of taking a full history of any herbal remedies or supplements in addition to prescription or over-the-counter medications taken when undergoing treatment for controlled FET cycles or in-vitro fertilization (IVF). To our knowledge, no studies to date have investigated this relationship.

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Endometrial Receptivity and Scoring for Prediction of Implantation and Newer Markers

Abstract: How to cite this article Malhotra N, Malhotra J, Singh A, Gupta P, Malhotra N. Endometrial Receptivity and Scoring for Prediction of Implantation and Newer Markers. J South Asian Feder Obst Gynae 2017;9(2):143-154.

Cited by 7 publications

References 32 publications

Autologous Platelet-Rich Plasma Infusion to Improve Pregnancy Outcome in Suboptimal Endometrium: A Review

Autologous Platelet-Rich Plasma Infusion to Improve Pregnancy Outcome in Suboptimal Endometrium: A Review

Endometrial Compaction in Response to Progesterone Administration and Good Endometrial Vascularity Improves the Clinical Pregnancy Rates in Hormone Replacement Frozen Embryo Transfers

Curcumin Supplementation and Endometrial Lining: Examining the Role and Pathophysiology of Use During Frozen-Thawed Embryo Transfer

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