Endometrial response to IVF hormonal manipulation: Comparative analysis of menopausal, down regulated and natural cycles

Terry, Vera; Hosie, Margot J.; Gayer, Nalini; Murphy, Christopher R.

doi:10.1186/1477-7827-2-21

Cited by 19 publications

(2 citation statements)

References 62 publications

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“…Earlier studies comparing IUI and IVF responses focused mainly on analyzing pregnancy outcomes [ 38 , 39 , 40 ], evaluating endometrial responses by measuring endometrium thickness [ 41 ], or investigating endometrial biology using electron microscopy, histochemical analysis of endometrial biopsies, or non-targeted proteomic analysis of endometrial fluid [ 42 , 43 , 44 ]. There have also been studies on changes in the cervical mucus (evaluated using the Insler score [ 2 ]) induced by hormonal hyperstimulation similar to that received by our IVF group [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Proteome Mapping of Cervical Mucus and Its Potential as a Source of Biomarkers in Female Tract Disorders

Oždian

Vodička

Dostál

et al. 2023

IJMS

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Cervical mucus (CM) is a viscous fluid that is produced by the cervical glands and functions as a uterine cervix plug. Its viscosity decreases during ovulation, providing a window for non-invasive sampling. This study focuses on proteomic characterization of CM to evaluate its potential as a non-invasively acquired source of biomarkers and in understanding of molecular (patho)physiology of the female genital tract. The first objective of this work was to optimize experimental workflow for CM processing and the second was to assess differences in the proteomic composition of CM during natural ovulatory cycles obtained from intrauterine insemination (IUI) cycles and in vitro fertilization (IVF) cycles with controlled ovarian hyperstimulation. Proteomic analysis of CM samples revealed 4370 proteins involved in processes including neutrophil degranulation, cellular stress responses, and hemostasis. Differential expression analysis revealed 199 proteins enriched in IUI samples and 422 enriched in IVF. The proteins enriched in IUI were involved in phosphatidic acid synthesis, responses to external stimulus, and neutrophil degranulation, while those enriched in IVF samples were linked to neutrophil degranulation, formation of a cornified envelope and hemostasis. Subsequent analyses clarified the protein composition of the CM and how it is altered by hormonal stimulation of the uterus.

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Section: Discussionmentioning

confidence: 99%

Proteome Mapping of Cervical Mucus and Its Potential as a Source of Biomarkers in Female Tract Disorders

Oždian

Vodička

Dostál

et al. 2023

IJMS

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“…Notably, both the studies assessed natural conceptions and did not include pregnancies achieved via assisted reproductive technology (ART). ART uses exogenous hormones, and the above studies could not account for this potential hormonal influence on the endometrium and trophoblastic invasion ( Adams et al 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Implantation in the lower half of the uterine cavity and decreased trophoblastic thickness can predict subsequent miscarriage: a prospective cohort study

Nancarrow,

Tempest,

Vinayagam

et al. 2023

Reproduction and Fertility

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Embryo implantation is vital for successful conception but remains to be fully understood. Trophoblast invasion is key for implantation, with anchorage and depth of placentation determined by its extent. There is a dearth of synchronous information regarding in vitro fertilisation (IVF), implantation site and trophoblastic thickness (TT). Our aim was to determine whether pregnancy implantation site and TT, had an impact on outcomes of IVF pregnancies. This prospective observational study was undertaken at a tertiary referral UK fertility unit over 14-months, collecting data on implantation site and TT from three-dimensional (3D) images of the uterus following early pregnancy scan. Of the 300 women recruited, 277 (92%) had live births, 20 (7%) miscarried, 2 (0.7%) had stillbirths and one (0.3%) had a termination. Significantly more pregnancies that resulted in miscarriage 7/20 (35%) were located in the lower uterine cavity when compared to ongoing pregnancies 15/277 (5%) (p<0.01). TT was significantly higher in ongoing pregnancies when compared with those who miscarried (7.2mm vs 5.5mm; p<0.01). Implantation in the lower half of the uterine cavity and decreased TT are significantly associated with an increased rate of miscarriage. Identification of those at risk should prompt increased monitoring with the aim of supporting these pregnancies.

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Natural cycle in vitro fertilisation (IVF) for subfertile couples

Allersma

Farquhar

Cantineau

2013

Cochrane Database of Systematic Reviews

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Endometrial response to IVF hormonal manipulation: Comparative analysis of menopausal, down regulated and natural cycles

Abstract: Background: Uterine luminal epithelial cell response to different hormonal strategies was examined to determine commonality when an endometrium attains a receptive, stimulated, morphological profile that may lead to successful implantation.

Cited by 19 publications

References 62 publications

Proteome Mapping of Cervical Mucus and Its Potential as a Source of Biomarkers in Female Tract Disorders

Proteome Mapping of Cervical Mucus and Its Potential as a Source of Biomarkers in Female Tract Disorders

Implantation in the lower half of the uterine cavity and decreased trophoblastic thickness can predict subsequent miscarriage: a prospective cohort study

Natural cycle in vitro fertilisation (IVF) for subfertile couples

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