Endometrial scratch injury for women with one or more previous failed embryo transfers: a systematic review and meta-analysis of randomized controlled trials

Abstract

The ESI may improve IVF success in patients with two or more previous ET failures undergoing fresh ET. The ESI timing and technique seem to play a crucial role in determining its effect on embryo implantation.

Effect of endometrial injury during menstruation on clinical outcomes in frozen–thawed embryo transfer cycles: A randomized control trial

“…[2][3][4][5][6][7][8][9][10]26,27 The statement above has also been proved by several recent meta-analysis studies. 10,14 However, in 2019, another two systematic reviews suggested that current evidence did not fully support performing EI with the purpose of improving success of a first ET attempt. 15,16 Therefore, the clinical application of EI is still in controversial, especially for the frozen-thawed ET process due to the lack of evidence.…”

“…The majority of EI trials have found that EI in luteal phase increased the IVF success rate . The statement above has also been proved by several recent meta‐analysis studies . However, in 2019, another two systematic reviews suggested that current evidence did not fully support performing EI with the purpose of improving success of a first ET attempt .…”

“…Among them, there are increasing studies indicate that EI is a very effective method that serves such purpose. [2][3][4][5][6][7][8][9][10] The procedure of EI is a relatively safe and effective operation, come with low cost and good toleration and usually can be performed in the out-patient-setting.…”

“…However, there is no consensus in the field up to date and the benefit of EI prior to embryo transfer is controversial. Specifically, some studies demonstrated that performing EI in luteal phase prior to in vitro fertilization (IVF)/ICSI improved implantation and clinical pregnancy rates, [2][3][4][5][6][7][8][9][10] in the meanwhile, there are some studies denied such benefit of EI. [11][12][13][14][15][16] It is important to point out that most previous studies focused on fresh embryo transfer.…”

The impact of endometrial injury on reproductive outcomes: results of an updated meta‐analysis

“…[9][10][11] Vitagliano et al showed improved reproductive outcomes in women with two or more previous failed cycles, with the greatest beneficial effect seen when double luteal EI was performed. 10 Van Hoogenhuijze et al found improved CPR but no improved LBR in women with at least two previous failed cycles, concluding that it is still unclear whether EI improves IVF outcomes. 9 In line with this meta-analysis, Gui et al did not find any significant difference in CPR or LBR when including only RCT in their analysis.…”