Endometrial surface adaptive changes during first half of pregnancy in mares

Souza, Andreza Morais de; Winter, Gustavo Henrique Zimmermann; Cazales, N.; Miglino, Maurizio; Mattos, Rodrigo Costa

doi:10.1016/j.jevs.2013.10.149

Cited by 3 publications

(2 citation statements)

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“…The endometrium of the ovulating mare is a deeply folded mucosal surface consisting of ciliated cells, secretory cells with apical microvilli and endometrial gland openings diffusely spread throughout the ridges and troughs along the surface (Souza et al, 2014). Changes to the surface during early pregnancy include a slow flattening of the folds, decreased presence of ciliated cells from day 35 of gestation to absence at day 62 days, and formation of microcaruncles around glandular openings (Souza et al, 2014).…”

Section: Placentation and General Anatomy Of The Mare Reproductive Trmentioning

confidence: 99%

“…Changes to the surface during early pregnancy include a slow flattening of the folds, decreased presence of ciliated cells from day 35 of gestation to absence at day 62 days, and formation of microcaruncles around glandular openings (Souza et al, 2014). Pathologic changes of the endometrium can lead to structural changes including fibrosis, loss of ciliated cells, and loss of the integrity of the mucosal barrier (Lu and Morresey, 2006).…”

Section: Placentation and General Anatomy Of The Mare Reproductive Trmentioning

confidence: 99%

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Pathology of equine amnionitis and foetal lLoss: clinical and experimental studies

Todhunter¹

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Detailed experience in identifying the appearance of setal fragments which is highlighted under toluidine blue staining allowed in depth examination of tissues from equine abortions submitted for examination in 2012. Five cases were found in which a caterpillar setal fragment was found in the allantochorion confirming that setal fragments migrate from field exposure as well as experimental exposure to processionary caterpillars.The experiments in this thesis have shown histologically for the first time, the ability of Processionary caterpillar setae to penetrate the maternal gut wall and migrate directly into the uterus and placental tissues. This is considered to be the most likely means of translocation of bacteria to the foetal membranes. The direct, rapid migration of setae in as little as two days from ingestion from the gut to the placenta facilitates bacterial infection.Bacteria present in the mare's gut likely attach to migrating setal fragments and translocate through the gut wall, the uterus and the foetal membranes in which they subsequently colonize. Incomplete migration of setal fragments may account for the focal mucoid placentitis induced when mares were exposed in early gestation. Bacterial colonization of 5 the foetal membranes and/or foetus may cause foetal compromise or death and eventual abortion.The variety of manifestations of EAFL due to the migration of setal fragments ranging from acute abortion, chronic active placentitis, stillbirth, compromised preterm and full term foals, and focal mucoid placentitis have a significant impact on the breeding of horses and ultimately the racing industry in Australia.6

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Section: Placentation and General Anatomy Of The Mare Reproductive Trmentioning

confidence: 99%

Section: Placentation and General Anatomy Of The Mare Reproductive Trmentioning

confidence: 99%

Pathology of equine amnionitis and foetal lLoss: clinical and experimental studies

Todhunter¹

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Endometrial Alterations After the Transfer of Embryonic Remains

Camacho

Caballeros

Cazales

et al. 2018

Journal of Equine Veterinary Science

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Ultrastructural and histological characteristics of the endometrium during early embryo development in mares

Camozzato

Martínez²,

Bastos

et al. 2019

Theriogenology

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The aim of this study was to evaluate ultrastructural and histological changes in the endometrium on days 7, 10 and 13 post-ovulation in pregnant and cyclic mares. Mares were routinely examined by transrectal palpation and ultrasonographic examination of the reproductive tract until estrus was detected. In the first cycle, endometrial biopsies from 30 cyclic mares (Cyclic group) were collected on days 7, 10 and 13 post-ovulation. In the second cycle, the same mares were bred by a fertile stallion. At days 7, 10 and 13 post-ovulation intrauterine biopsies were collected. Immediately after sample collection, the mare's uteri were flushed, and those mares with embryo recovery were assigned to the Pregnant group. From ovulation detection until day of uterine biopsy, blood samples to measure Progesterone concentrations were collected daily in cyclic and pregnant mares. A larger blood vessel caliber was observed in pregnant mares than in cyclic from day 7-13. On the 7th day of pregnancy a large loss of ciliated cells was evident in the group of pregnant mares in comparison with the Cyclic group and the superficial cells of the endometrium were more protruded, and a small amount of histotrophic material between the folds was observed. On the 10th day of pregnancy, the glandular histotrophic secretion and the secretion of luminal epithelium became more intense than the secretion of cyclic mares. On the 13th day of pregnancy, a very large amount of histotroph was observed within large glandular openings surrounded by ciliated cells. The concentrations of P4 were affected by day (P < 0.001), but were not affected by group. Changes occurred in the uterine environment thereupon the entry of the embryo into the uterus. In the stroma and in the lumen, these modifications may aid to provide the necessary nutrition for the initial development of the embryo and to promote changes at cellular structures that will interact in the embryonic signaling and future fixation, implantation and placentation.

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Endometrial surface adaptive changes during first half of pregnancy in mares

Cited by 3 publications

References 1 publication

Pathology of equine amnionitis and foetal lLoss: clinical and experimental studies

Pathology of equine amnionitis and foetal lLoss: clinical and experimental studies

Endometrial Alterations After the Transfer of Embryonic Remains

Ultrastructural and histological characteristics of the endometrium during early embryo development in mares

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