Endometriosis as a Manifestation of Ovarian Dysfunction.*

Jeffcoate, T. N. A.; Potter, A.

doi:10.1111/j.1471-0528.1934.tb08800.x

Cited by 28 publications

(2 citation statements)

References 19 publications

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“…As early as 1934, Jeffcoates and Potter [105] hypothesised that “an over-production of oestrin by the ovary is the most important factor in the development of endometriomata in any site”. They stated: “since the ectopic endometrium reacts to ovarian hormones in exactly the same way as does the uterine mucosa, its histologic appearance permits an estimation of ovarian function, normal or otherwise.” This view was strongly opposed by Novak and de Lima [106], since there was no evidence of secretory changes in the ectopic endometrium in adenomyosis in the cases they examined, regardless of the phase of the cycle.…”

Section: Adenomyosis In Patients With Endometrial Cancermentioning

confidence: 99%

Adenomyosis and Endometrial Cancer: Literature Review

Habiba

Pluchino

Petignat

et al. 2018

Gynecol Obstet Invest

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To confirm the origin of cancer found in both the endometrium and the myometrium is difficult. Cancer may spread from the endometrium into adenomyotic foci or vice versa. Also, premalignant changes may arise at either or both sites. Investigating disease origin enhances our understanding of pathophysiology and prognosis. Additional critical questions are whether women with adenomyosis have a higher risk of endometrial cancer; whether the invasive properties and prognosis of cancer in adenomyosis differ from those arising in the eutopic endometrium and whether the ectopic glandular tissue in adenomyosis becomes altered in the presence of eutopic endometrial cancer. A final question is whether cancer arising within adenomyosis carries a worse prognosis because of its location within the myometrium and the possibility that the presence of adenomyosis facilitates invasion of cancer arising in the eutopic endometrium. The present review explores currently available literature in an attempt to answer these questions and to examine clinical presentations, diagnostic criteria, pathogenesis and prognosis.

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