Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract

Kapczuk, Karina; Zajączkowska, Weronika; Madziar, Klaudyna; Kędzia, Witold

doi:10.3390/jcm12052007

Cited by 11 publications

(6 citation statements)

References 23 publications

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“…10 This is of particular importance for adolescents being diagnosed with and treated for obstructive anomalies, where more than 50% may have evidence of endometriosis at the time of surgical management. 11 Appropriate treatment of endometriosis may have beneficial early-life consequences on educational attainment, early career productivity, and comorbid psychological conditions. [12][13][14][15] It is unknown whether concurrent surgical excision of endometriosis at the time of surgical correction of obstructive anomalies is associated with long-term improvement in reproductive outcomes.…”

Section: Presentationmentioning

confidence: 99%

Müllerian Anomalies

Bortoletto,

Romanski,

Pfeifer

2023

Obstetrics &Amp; Gynecology

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Müllerian anomalies represent a complex collection of developmental defects occurring in up to 5% of the general population. They are increasingly more common in individuals with infertility (8.0%) and in those with a history of pregnancy loss (13.3%); they have the highest prevalence in individuals with a history of both (24.5%). A wide spectrum of anomalies can occur based on the stage at which müllerian development ceases in utero, ranging from mild (eg, a partial uterine septum) to severe, with complete absence of the cervix, uterus, and fallopian tubes (eg, müllerian agenesis). The components of the reproductive tract involved and, importantly, whether an obstruction of the tract is involved correlates with the timing of presentation, the constellation of associated symptoms, and the necessity for either medical or surgical management. Individuals, regardless of the severity of the defect, should be counseled on the gynecologic, reproductive, and obstetric risks associated with their specific müllerian anomaly to minimize adverse sequela and outcomes. We will review the clinical presentation, diagnostic evaluation, and clinical counseling of individuals with müllerian anomalies.

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Section: Presentationmentioning

confidence: 99%

Müllerian Anomalies

Bortoletto,

Romanski,

Pfeifer

2023

Obstetrics &Amp; Gynecology

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Section: Examination and Imagingmentioning

confidence: 99%

“…In one study, authors laparoscopically confirmed endometriosis in 23 of 50 (46%) adolescents undergoing surgical treatment for obstructive reproductive anomalies after menarche. 23 Specific anomalies may further increase the risk of endometriosis; a higher proportion of adolescents with cervical aplasia were diagnosed with endometriosis compared with those with other anomalies. 23 When obtaining a pelvic ultrasonogram, a transabdominal approach should be the initial choice to minimize discomfort.…”

Section: Examination and Imagingmentioning

confidence: 99%

“…23 Specific anomalies may further increase the risk of endometriosis; a higher proportion of adolescents with cervical aplasia were diagnosed with endometriosis compared with those with other anomalies. 23 When obtaining a pelvic ultrasonogram, a transabdominal approach should be the initial choice to minimize discomfort. In one study of adolescents who underwent pelvic ultrasound imaging (transvaginal if sexually active and transrectal if never sexually active), at least one ultrasound feature of endometriosis was identified in 36 of the 270 cases (13.3%), including ovarian endometrioma (11%), adenomyosis (5.2%), and deep infiltrating endometriosis (3.7%).…”

Section: Examination and Imagingmentioning

confidence: 99%

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Evaluation and Management of Endometriosis in the Adolescent

Shim,

Laufer,

King

et al. 2023

Obstetrics &Amp; Gynecology

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Endometriosis is a chronic condition, with debilitating symptoms affecting all ages. Dysmenorrhea and pelvic pain often begin in adolescence, affecting school, daily activities, and relationships. Despite the profound burden of endometriosis, many adolescents experience suboptimal management and significant delay in diagnosis. The symptomatology and laparoscopic findings of endometriosis in adolescents are often different than in adults, and the medical and surgical treatments for adolescents may differ from those for adults as well. This Narrative Review summarizes the diagnosis, evaluation, and management of endometriosis in adolescents. Given the unique challenges and complexities associated with diagnosing endometriosis in this age group, it is crucial to maintain a heightened level of suspicion and to remain vigilant for signs and symptoms. By maintaining this lower threshold for consideration, we can ensure timely and accurate diagnosis, enabling early intervention and improved management in our adolescent patients.

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“…Matalliotakis et al reported that the congenital structural abnormality of the reproductive organs was observed much more in the younger cases (16/55, 32%), compared with the older cases (14/485, 1.6%) [ 5 ]. Another study reported that endometriosis was diagnosed in 23/50 (46%) of patients with obstructive Müllerian anomalies [ 6 ]. On the other hand, patients without Müllerian anomalies can also develop endometriosis at young ages.…”

Section: Introductionmentioning

confidence: 99%

The Association between Endometriosis and Obstructive Müllerian Anomalies

Takahashi,

Harada,

Kanatani

et al. 2024

Biomedicines

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It is unclear whether clinical background differs between endometriosis in adolescent patients with obstructive Müllerian anomalies and those without anomalies. The aim of the study is to identify the difference in clinical characteristics of endometriosis in patients with or without obstructive Müllerian anomalies. The study involved 12 patients aged under 24 years old who underwent primary surgery for obstructive Müllerian anomalies and 31 patients aged under 24 years old who underwent surgery for ovarian endometrioma. A total of 6 out of 12 cases with obstructive Müllerian anomalies developed endometriosis (4 Herlyn–Werner–Wunderlich syndrome, 2 non-communicating functional uterine horn, 2 cervical aplasia). The age at surgery was significantly younger in endometriosis with obstructive Müllerian anomalies, compared with those without obstructive Müllerian anomalies (17.8 ± 4.4 vs. 23.1 ± 1.3, p = 0.0007). The rate of endometrioma was 50.0% and the rate of hydrosalpinx was significantly higher (66.7% vs. 0%, p = 0.0002) in the group of obstructive Müllerian anomalies. The recurrence rate of endometriosis was 20.0% in the group of anomalies and 25.9% in the group of those without anomalies. Adolescent patients with obstructive Müllerian anomalies more easily developed endometriosis and co-occurred with higher rate of hematosalipinx.

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Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract

Cited by 11 publications

References 23 publications

Müllerian Anomalies

Müllerian Anomalies

Evaluation and Management of Endometriosis in the Adolescent

The Association between Endometriosis and Obstructive Müllerian Anomalies

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