Endometriosis: novel etiopathogenetic concepts and clinical perspectives

Vignali, Mario; Infantino, Mirco; Matrone, Roberta; Chiodo, Ilda; Somigliana, Edgardo; Busacca, Mauro; Viganò, Paola

doi:10.1016/s0015-0282(02)03233-8

Cited by 115 publications

(75 citation statements)

References 73 publications

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“…28 However, not all women with pelvic endometriosis have endometriotic ovarian cysts, which in turn may have developed in some cases from follicular or luteal cysts. 3 Therefore, if real, the reduced risk is either associated with cysts in general or there is a much stronger protective effect associated with one or more specific subtypes.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of endometriomas is unclear but may be related to functional ovarian cysts in at least some cases. 3 The etiologies of individual simple or functional cysts and of polycystic ovaries are not well understood, but all cysts are likely to be linked to altered gonadotropin secretion, which influences and is influenced by steroid hormones including estrogens, progestins and androgens. Early oral contraceptive formulations were associated with reduced ovarian cyst occurrence, but this relationship appears to have attenuated with more recent, lower-dose formulations.…”

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confidence: 99%

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An inverse association between ovarian cysts and breast cancer in the breast cancer family registry

Knight

John

Milne

et al. 2005

Intl Journal of Cancer

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Ovarian cysts of several types are common in women of reproductive age. Their etiology is not well understood but is likely related to perturbations in the hypothalamic-pituitary-gonadal axis. The relationship of ovarian cysts to breast cancer risk is not known, although a negative association with polycystic ovarian syndrome has been reported. Incident, invasive female breast cancer cases, population-based controls and unaffected sisters of cases were studied from 3 countries participating in the Breast Cancer Family Registry: Melbourne and Sydney, Australia; the San Francisco Bay Area, USA; and Ontario, Canada. Using the same questionnaire, information was collected on self-reported history of ovarian cysts and other risk factors. Analyses were based on 3,049 cases, 2,344 population controls and 1,934 sister controls from all sites combined. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using both unconditional and conditional logistic regression using an offset term to account for sampling fractions at 2 of the sites. A significantly reduced risk of breast cancer was observed for women reporting a history of ovarian cysts (OR 5 0.70, 95% CI 0.59-0.82, among all cases and all controls). This risk estimate was similar regardless of control group used, within all 3 sites and in both premenopausal and postmenopausal women (ORs ranging from 0.68-0.75, all 95% CI excluded 1.00). A self-reported history of ovarian cysts was strongly and consistently associated with a reduced risk of breast cancer. Further study of ovarian cysts may increase our understanding of hormonal and other mechanisms of breast cancer etiology. ' 2005 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

An inverse association between ovarian cysts and breast cancer in the breast cancer family registry

Knight

John

Milne

et al. 2005

Intl Journal of Cancer

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“…It is ma inly a di se a se of the wo men of rep ro duc ti ve age and its es ti ma ted in ci den ce is 10%. 1,2 Va ri o us the o ri es on its eti o logy such as ret rog ra de mens trua ti on and di rect imp lan ta ti on, vas cu lar in va si on, lack of im mu ne res pon se, and ge ne tic fac tors ha ve be en pro po sed. Ho we ver, the exact eti o logy has not be en de fi ned yet.…”

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confidence: 99%

“…Ho we ver, the exact eti o logy has not be en de fi ned yet. [1][2][3][4] En do met ri o sis is an es tro gen de pen dent di se ase. The se fo ci in vol ve es tro gen re cep tors and es troge nic sti mu la ti on in cre a ses the de ve lop ment of en do met ri o sis fo ci.…”

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“…The se fo ci in vol ve es tro gen re cep tors and es troge nic sti mu la ti on in cre a ses the de ve lop ment of en do met ri o sis fo ci. 1,2 Va ri o us agents [pro ges tins, go na dot ro pin rele a sing hor mo ne ana logs (GnRHa), com bi ned oral con tra cep ti ves, da na zol] used in the me di cal treat ment of en do met ri o sis show the ir ef fects by anti-es tro ge nic ac ti vity. 5 The tre at ment of en do metri o sis was in ves ti ga ted in ear li er stu di es with a rat mo del using GnRHa and go na dot ro pin re le a sing hor mo ne an ta go nists and va ri o us agents such as pen to xiphy lli ne, doxyc ycli ne, and le va mi zol.…”

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Therapeutic Efficiency of Tibolone in a Rat Endometriosis Model

Şimşek¹,

Ceyhan²,

Üstün³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : This study ai med to eva lu a te the the ra pe u tic ef fi ci ency of ti bo lo ne in an ex pe ri men tal rat mo del of in tra-ab do mi nal en do met ri o sis. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In this ex pe rimen tal study, in tra-ab do mi nal en do met ri o sis was in du ced in 30 fe ma le rats sur gi cally. Fo ur we eks af ter this pro ce du re, la pa ro tomy was per for med again. The di men si ons of the en do met ri o sis fo ci were re cor ded and right af ter, the ope ra ti on was comp le ted. Rats we re ran domly di vi ded in to thre e gro ups and sub se qu ently, the tre at ment was star ted. In the first gro up (n= 8), a sing le do se of 1 cc 0.9% NaCl was in jec ted sub cu ta ne o usly. In the se cond gro up (n= 8), in tra mus cu lar in jec ti on of 1 mg le up ro lid ace ta te was ad mi nis te red. In the third gro up (n= 8), 1 mg/kg/day of ti bo lo ne was gi ven by ga va ge. At the end of 4-we eks of drug ad mi nis tra ti on, la pa ro tomy was per for med to all rats. The di men si ons of the en do met ri o sis fo ci we re re cor ded. Af ter wards, all the rats we re sac ri fi ced. The dif fe ren ces in the are as of en do met ri o tic imp lants and ad he si on sco res we re com pa red bet we en the gro ups. R Re e s su ul lt ts s: : The di men si ons of the en do met ri o sis fo ci in the gro ups tre a ted with le up ro lid (p< 0.05) and ti bo lo ne (p< 0.05) we re sig ni fi cantly di mi nis hed compared to that of the con trol gro up. No sta tis ti cally sig ni fi cant dif fe ren ces we re fo und bet we en the tre at ment gro ups. C Co on nc c l lu u s si i o on n: : In a rat en do met ri o sis mo del, ti bo lo ne has a si mi lar ef fi ci ency as that of le up ro lid ace ta te, an agent used for con ven ti o nal me di cal tre at ment of en do met ri o sis. With its an dro ge nic and pro ges ta ge nic charac te ris tics, ti bo lo ne de ser ves at ten ti on as an al ter na ti ve agent in the me di cal tre at ment of en domet ri o sis in hu man. K Ke ey y W Wo or rd ds s: : Rats; endometriosis; gonadotropin-releasing hormone; tibolone Ö ÖZ ZE ET T A Am ma aç ç: : Bu ça lış ma da ka rın içi en do met ri o zis li de ney sel sı çan mo de lin de ti bo lon un te ra pö tik et kin li ği nin de ğer len di ril me si amaç lan dı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu de ney sel ça lış ma da, 30 di şi sı çan -da ka rın içi cer ra hi en do met ri o zis mey da na ge ti ril di. Bu iş lem den dört haf ta son ra tekrar la pa ro tomi ya pıl dı. En do met ri o zis odak la rı nın bo yut la rı kay de dil di he men ar dın dan ope ras yon ta mam lan dı. Sı çan lar rast ge le üç gru ba ay rıl dı ve da ha son ra te da vi baş lan dı. Bi rin ci gru ba (n= 8), NaCl 1 cc %0.9 tek doz ola rak cilt al tı na en jek te edil di. İkin ci gru ba (n= 8), le up ro lid ase tat 1 mg in tra mus kü ler ola rak uy gu lan dı. Üçün cü gru ba (n= 8), ti bo lon 1mg/kg/gün ola rak ga vaj ile ve ril di. Dört haf ta ilaç alı mı nın son ra s...

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