Endophthalmitis or toxic anterior segment syndrome?

Lee, Matthew Hao; Cugley, Dean; Atik, Alp; Ang, Ghee Soon

doi:10.1111/cxo.12426

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…Patient complaining of pain in the operated eye on the day of surgery with thick white precipitate sedimented in the anterior chamber is an alert for the ophthalmologist to be on standby. Apart from the most obvious infectious endophthalmitis, foreign particles used in surgery and toxic anterior segment syndrome (TASS) must be considered in differential diagnosis [7, 8]. The main distinctions between infectious endophthalmitis and TASS are onset and progression of symptoms as well as the presence of pain and vitritis [7].…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the most obvious infectious endophthalmitis, foreign particles used in surgery and toxic anterior segment syndrome (TASS) must be considered in differential diagnosis [7, 8]. The main distinctions between infectious endophthalmitis and TASS are onset and progression of symptoms as well as the presence of pain and vitritis [7]. However, in both conditions corneal involvement and major inflammatory reaction in the anterior chamber are present [7].…”

Section: Discussionmentioning

confidence: 99%

“…The main distinctions between infectious endophthalmitis and TASS are onset and progression of symptoms as well as the presence of pain and vitritis [7]. However, in both conditions corneal involvement and major inflammatory reaction in the anterior chamber are present [7]. The following criteria excluded the diagnoses of endophthalmitis and TASS: clear and transparent anterior chamber and vitreous body, absence of ciliary injection and corneal oedema, and unremarkable laboratory tests' results as well as the fact that the pain decreased on the tetracaine drops.…”

Section: Discussionmentioning

confidence: 99%

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Physical Incompatibility between Vancomycin and Viscoelastic Mimicking Acute Endophthalmitis: The First Report

Elabjer

Šarić

Bušić

et al. 2019

Case Reports in Ophthalmological Medicine

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This is the first documentation of vancomycin precipitation with viscoelastic in the anterior chamber of the eye. A 34-year-old white male underwent uneventful penetrating keratoplasty. Intracameral instillation of 1 mg/0.1 mL of vancomycin followed no attempts of meticulous viscoelastic irrigation. Six hours later thick white material in the anterior chamber was sedimented. The following criteria excluded the diagnosis of endophthalmitis and TASS: clear and transparent anterior chamber and vitreous body, the absence of ciliary injection and corneal oedema, and unremarkable laboratory tests’ results. This iatrogenic complication mimicking endophthalmitis does not require any specific management and should be acknowledged in guidelines for prevention and treatment of endophthalmitis. The objective of this paper is to alert colleagues to this iatrogenic complication of vancomycin mimicking endophthalmitis. Whether this condition should be labelled as positive or negative demands further investigation. As vancomycin is a time-dependent antibiotic, it is possible that this precipitate could serve as a slowly releasing drug depot and viscoelastic as a vehicle for precipitation. This being the case, investigation is needed to analyse its potential to precipitate with another dispersive and cohesive viscoelasticity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Physical Incompatibility between Vancomycin and Viscoelastic Mimicking Acute Endophthalmitis: The First Report

Elabjer

Šarić

Bušić

et al. 2019

Case Reports in Ophthalmological Medicine

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“…Embora a apresentação clínica da EPO seja bem conhecida, o diagnóstico diferencial da síndrome tóxica do segmento anterior pode ser difícil 16 e levar à subnotificação dos casos. Assim, o desenvolvimento de ferramentas para a busca ativa dos casos com alta sensibilidade e especificidade para endoftalmite é necessário para uma vigilância epidemiológica apropriada.…”

Section: Discussionunclassified

“…A vigilância da EPO é, muitas vezes, desafiadora, por duas razões principais. Em primeiro lugar, muitos cirurgiões não relatam os casos de infecção; em segundo, as características da apresentação clínica da endoftalmite podem ser parecidas com a síndrome tóxica do segmento anterior 16,17 e alguns casos podem não ser diagnosticados corretamente, levando a taxas imprecisas.…”

Section: Introductionunclassified

Seleção de marcadores para a busca ativa de endoftalmite após cirurgia de catarata

Luz

Cvintal²,

Silva³

et al. 2018

Rev SOBECC

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Objetivo: Identificar marcadores potenciais para auxiliar na busca ativa de endoftalmite após cirurgia de catarata. Método: Estudo retrospectivo, descritivoe longitudinal, realizado por meio da revisão de prontuários de pacientes submetidos à cirurgia de catarata. Resultados: A amostra incluiu 20 pacientes(grupo de estudo — GE) que desenvolveram endoftalmite pós-operatória e 309 pacientes (grupo controle — GC) que não apresentaram endoftalmite. Os dadosforam analisados para identificar os marcadores clínicos e epidemiológicos com uma diferença percentual ≥30% entre os grupos. Em comparação com o GC,o GE teve frequência ≥30% em: sinais e sintomas pós-operatórios definidos (dor, reação da câmara anterior, hipópio, edema da córnea, hiperemia conjuntivale opacidade vítrea); mais de 4 retornos pós-operatórios; e realização de injeção de antibiótico intravítreo. Conclusão: Os indicadores selecionados são sugeridospara incorporação na busca ativa das infecções pós-operatórias de endoftalmite, visando à facilidade operacional do sistema de vigilância epidemiológica.

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