Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites

Kaul, Sanjana; Gupta, Suruchi; Ahmed, Maroof; Dhar, Manoj K.

doi:10.1007/s11101-012-9260-6

Cited by 308 publications

(177 citation statements)

References 99 publications

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“…Moreover, endophytes comprise a promising rich source of potential bioactive medicinal constituents such as podophyllotoxin (Canel et al 2000), paclitaxel (Taxol) (Stierle et al 1993), hypericin (Kusari et al 2008) and camptothecin (Kusari et al 2009). Generally, medicinal plants used in traditional medicine are selected for surveying bioactive endophytic fungi due to documented beneficial applications (Kaul et al 2012; Kusari et al 2013) and thus, high likelihood of producing pharmaceutically important secondary metabolites.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

Pansanit

Pripdeevech

2018

Mycology

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Forty-four endophytes were isolated from Zingiber cassumunar and identified morphologically. The ethyl acetate extracts of all endophytes were obtained. The ethyl acetate extracts were subjected to study antibacterial and antioxidant activities. The ethyl acetate extract of the Arthrinium sp. MFLUCC16-1053 showed activity against both gram-positive and gram-negative bacteria. Specifically, the minimum inhibition concentration against Staphylococcus aureus and Escherichia coli was 31.25 and 7.81 µg/mL, respectively. In addition, the crude extract showed highest antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenging at IC50 value of 28.47 µg/mL. Gas chromatography-mass spectrometry analysis revealed that the extract of the Arthrinium sp. MFLUCC16-1053 contains various antibacterial and antioxidant compounds which are β-cyclocitral, 3E-cembrene A, laurenan-2-one, sclareol, 2Z,6E-farnesol, cembrene, β-isocomene and γ-curcumene. The fungus Arthrinium sp. MFLUCC16-1053 was also identified by molecular and phylogenetic methods.

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Section: Introductionmentioning

confidence: 99%

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

Pansanit

Pripdeevech

2018

Mycology

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“…These are known as endophytic fungi. Endophytic fungi have been reported to be lucrative sources of bioactive compounds possessing antibacterial, anti-cancer, cytotoxic, neuroprotective and antioxidant activities some of which are under clinical trials 5 . Bio-prospecting of endophytic fungi for production of PL inhibitors is a nascent area with very scanty preliminary data.…”

Section: Introductionmentioning

confidence: 99%

Potential pancreatic lipase inhibitory activity of an endophyticPenicilliumspecies

Gupta

Saxena

Goyal

2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…These microorganisms include endophytic fungi, which, according to the definition of Bacon and White, inhabit internal plant tissue without causing any immediate harm (Chapla et al, 2013;Kharwar et al, 2011;Kaul et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of crude extracts of endophytic fungi from Oryctanthus alveolatus (Kunth) Kuijt (Mistletoe)

Sanay¹,

Armando²,

Hathyla³

et al. 2018

Afr. J. Microbiol. Res.

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The use of antibiotics has unleashed high bacterial resistance. This outcome triggered the urgent need for effective new antibacterial agents to treat infectious diseases. A promising source for the production of antibiotics and several other bioactive substances are endophytic fungi. These microorganisms inhabit in and bring benefits to living plant tissues. Thus, the aim of this paper was to know the endophytic fungi associated with Oryctanthus alveolatus (mistletoe) and assess their potential to inhibit pathogenic bacteria. A total of 86 endophytic fungi were isolated from the stems and leaves of O. alveolatus. Of these fungi, 29 were selected for the assessment of antimicrobial activity. The antimicrobial activity of the obtained extracts was evaluated using the agar diffusion method towards two Gram-positive pathogenic bacteria (Staphylococcus aureus and Staphylococcus epidermidis) and two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). The extracts were tested at concentrations of 200, 500, 700, 800, 900 and 1000 µg.mL -1 . The antimicrobial test showed that two (COA 009 and 014) of the 29 extracts inhibited bacterial growth of at least one of the strains each, from both Gram-positive and Gram-negative bacteria. The extracts with the inhibitory activity were derived from the fungi Curvularia sp. (COA 009) and Diaporthe sp. (COA 014).

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Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites

Cited by 308 publications

References 99 publications

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

Potential pancreatic lipase inhibitory activity of an endophyticPenicilliumspecies

Antimicrobial activity of crude extracts of endophytic fungi from Oryctanthus alveolatus (Kunth) Kuijt (Mistletoe)

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