Endophytic fungi from medicinal plants: biodiversity and biotechnological applications

Rana, Kusam Lata; Kour, Divjot; Kaur, Tanvir; Devi, Rubee; Negi, Chandranandani; Yadav, Ajar Nath; Yadav, Neelam; Singh, Karan; Saxena, Anil Kumar

doi:10.1016/b978-0-12-819654-0.00011-9

Cited by 46 publications

(28 citation statements)

References 168 publications

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“…In developing countries like India, almost 80% of folks use remedies derived from medicinal plants to cure their ailments. Medicinal plants are identified as a rich source of naturally derived secondary metabolites to cure diseases aliments [ 172 ]. Therefore, the presence of endophytic microflora seems to be beneficial to their host since the production of secondary metabolites is owed to these residing endophytic communities.…”

Section: Biopotential Of Isolated Fungal Endophytes From Thar Desert Plantsmentioning

confidence: 99%

Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals

Yadav

Meena

2021

Biotechnology Reports

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Highlights Endophytes act as chemical synthesizers of the secondary metabolites of the host plant. Endophytic microflora has been isolated from a wide array of plants. It can serve as a good alternative source for pharmaceutically important compounds. The arid ecosystem of Thar Desert is a rich repository of ethnomedicinal plants. Role of endophytes in the synthesis of bioactive molecules used to enhance production.

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Section: Biopotential Of Isolated Fungal Endophytes From Thar Desert Plantsmentioning

confidence: 99%

Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals

Yadav

Meena

2021

Biotechnology Reports

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“…Endophytic fungi have been in centre stage for production of plant-based anticancer agents ever since the discovery of Taxomyces andreanae from Taxus brevifolia which produced taxol in the free fermenting conditions (Stierle et al 1995 ). Since then a number of endophytic fungi have been explored, documented which have the inherent potential to produce anticancer phytomedicines such as camptothecin, podophyllotoxin, vincristine and vinblastine via fermentative route (Aly et al 2010 ; Kharwar et al 2011 ; Rana et al 2020 ). As endophytic fungi have been recognized as a treasure trove of new chemical entities with a spectrum of bioactivities, it becomes relevant to explore their cytotoxic effects using in vitro assays.…”

Section: Pharmaceutically Active Metabolitesmentioning

confidence: 99%

“…Today, endophytic fungi producing phytomedicines such as camptothecin, podophyllotoxin, huperzine and vincristine have been well studied (Aly et al 2011b ; Nisa et al 2015 ). Apart from producing the phytomedicines, the endophytic fungi exist under a variety of biotic and abiotic stress which render them metabolically active thereby producing novel chemical entities which help in sustaining themselves in the torrid internal environment of the plants (Braga et al 2016 ; Rana et al 2020 ). Over the last two decades, endophytic fungi have been recognized as a lucrative and prolific source of novel chemistries which could be developed into newer medicines as well as environment and user-friendly agrochemical (Zhang et al 2006 ; Gouda et al 2016 ; Martinez-Klimova et al 2017 ; Al-Ani 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Biologically Active Secondary Metabolites from Endophytic Alternaria Species

Saxena

2021

Endophytes

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Microbial secondary metabolites have contributed immensely in the development of a variety of medicines, namely antibiotics, metabolic inhibitors, immunomodulatory agents, antioxidants and anticancer agents. Endophytism in the past decade has further opened avenues of exploration and exploitation of new chemical entities produced during the plant–microbe interaction for pharmaceutical as well as agricultural applications. Alternaria is a genus belonging to ascomycete and generally comprise of members which cause agricultural spoilage, involved in decay and decomposition and some exist as opportunistic human pathogens. The genus is a prolific producer of secondary metabolites, which are finding applications in the agrochemical as well as pharmaceutical industry. The present review is an update on specialized members of Alternaria genus existing as an endophyte and the new chemical entities produced by them possessing agrobiological and pharmacological properties.

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“…However, on infection with endophytes, plants become healthy and exhibit enhanced tolerance to abiotic and biotic stress compared to their endophyte-free counterparts (Bonnet et al 2000 ). Endophytic microbes can be bacteria, actinomycetes, or fungi (Rana et al 2019a ; 2020a , c ).…”

Section: Endophytesmentioning

confidence: 99%

Endophytic Microbiomes and Their Plant Growth-Promoting Attributes for Plant Health

Ghosh

Bhagwat

Webster

2020

Environmental and Microbial Biotechnology

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Endophytes reside within internal tissues of living plants without causing any harm to the host. The influence of these microbial communities on plant growth, yield, stress, and disease resistance, has been identified as potential research priorities in agriculture. In this chapter, we aim to explore the diverse host–endophyte interactions for plant growth promotion and health. Initially, the colonization of endophytes in specific plant tissues is discussed along with their mechanism of entry, habitat selection, response to stimuli, and evasion of the plant immunity. Endophytic microbes promote plant growth through different types of direct and indirect mechanisms. Plant growth-promoting endophytes (PGPE) play a vital role in phytohormone production, nutrient acquisition, nitrogen fixation, and solubilization of minerals. Further, indirect mechanisms (like suppression of plant pathogens by producing volatile organic compounds, antagonizing agents, and quorum quenchers) are also discussed in detail. Siderophores production and the secretion of different hydrolytic enzymes like chitinases, glucanases, and proteases also help in the induction of systemic resistance and protection of the host plants. Bioactive metabolites derived from endophytes serve as excellent therapeutic agents and have potential applications in agriculture, cosmetics, pharmaceutical, and food industries. Hereby, this chapter highlights the scientific rationale behind using endophytic microbiomes as potential biofertilizers, biopesticides, and biocontrol agents.

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Endophytic fungi from medicinal plants: biodiversity and biotechnological applications

Cited by 46 publications

References 168 publications

Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals

Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals

Biologically Active Secondary Metabolites from Endophytic Alternaria Species

Endophytic Microbiomes and Their Plant Growth-Promoting Attributes for Plant Health

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