Endoplasmic Reticulum in Metaplasticity: From Information Processing to Synaptic Proteostasis

Khan, Shumsuzzaman

doi:10.1007/s12035-022-02916-1

Cited by 8 publications

(6 citation statements)

References 235 publications

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“…KEGG pathway analysis showed that DEGs were significantly enriched in protein processing in the endoplasmic reticulum pathway, which not only represents a unique protein-synthesizing mechanism, but also is a crucial factor for efficient neural communications [ 45 ]. Transport from the endoplasmic reticulum (ER) to the Golgi is an essential cellular process in the secretory pathway, and selective export of proteins from the ER requires transport signals for efficient recruitment of a transmembrane intracellular lectin ER–Golgi intermediate compartment protein 53 (ERGIC-53) into budding vesicles [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Full-Length Transcriptomes and Sex-Based Differentially Expressed Genes in the Brain and Ganglia of Giant River Prawn Macrobrachium rosenbergii

et al. 2023

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Macrobrachium rosenbergii is an important aquaculture prawn that exhibits sexual dimorphism in growth, with males growing much faster than females. However, the mechanisms controlling these complex traits are not well understood. The nervous system plays an important role in regulating life functions. In the present work, we applied PacBio RNA-seq to obtain and characterize the full-length transcriptomes of the brains and thoracic ganglia of female and male prawns, and we performed comparative transcriptome analysis of female and male prawns. A total of 159.1-Gb of subreads were obtained with an average length of 2175 bp and 93.2% completeness. A total of 84,627 high-quality unigenes were generated and annotated with functional databases. A total of 6367 transcript factors and 6287 LncRNAs were predicted. In total, 5287 and 6211 significantly differentially expressed genes (DEGs) were found in the brain and thoracic ganglion, respectively, and confirmed by qRT-PCR. Of the 435 genes associated with protein processing pathways in the endoplasmic reticula, 42 DEGs were detected, and 21/26 DEGs with upregulated expression in the male brain/thoracic ganglion. The DEGs in this pathway are regulated by multiple LncRNAs in polypeptide folding and misfolded protein degradation in the different organs and sexes of the prawn. Our results provide novel theories and insights for studying the nervous system, sexual control, and growth dimorphism.

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Section: Discussionmentioning

confidence: 99%

Full-Length Transcriptomes and Sex-Based Differentially Expressed Genes in the Brain and Ganglia of Giant River Prawn Macrobrachium rosenbergii

et al. 2023

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“…KEGG pathway analysis showed that DEGs were significantly enriched in the protein processing in the endoplasmic reticulum pathway, which not only would be a unique protein-synthesizing mechanism, but also is a crucial player in efficient neural communications (Khan 2022). Endoplasmic reticulum (ER)-to-Golgi trafficking is an essential cellular process in the secretory pathway, and selective export of proteins from the ER requires transport signals for efficient recruitment of a transmembrane intracellular lectin ER-Golgi intermediate compartment protein 53 (ERGIC-53) into budding vesicles (Nuferet al 2003).…”

Section: Discussionmentioning

confidence: 99%

Full-length transcriptomes of brain and ganglia and sex-based differentially-expressed genes involved in growth dimorphism of giant river prawn Macrobrachium rosenbergii

Liu

Hong

Gui

et al. 2022

Preprint

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The giant river prawn Macrobrachium rosenbergii is an important aquaculture prawn, showing sexual dimorphism in growth, with males growing much faster than females. However, the mechanisms controlling these complex traits are not yet well understood. The nervous system plays an important role in regulating life functions. This study aimed to obtain and characterize the full-length transcriptomes of brain and ganglion in female and male prawns by PacBio RNA sequencing. Based on the result of PacBio sequencing, transcript’s functional annotation, transcript factors, and simple sequence repeat analysis, long non-coding RNAs (LncRNAs) and transposable element predictions were accomplished. Total 159.1-Gb subreads were obtained and average length was 2,175 bp, with 93.2% completeness. After clustering and polishing, 84,627 high quality unigene sequences were produced and annotated by functional databases. 6,367 transcript factors and 6,287 LncRNAs were predicted. Illumina sequencing of brains and ganglia extracted from female and male prawns was carried out. A significant number of differentially expressed genes (DEGs) were found and confirmed by qRT-PCR analysis. Of the related 435 genes in protein processing pathways in the endoplasmic reticula, compared to females, 42 DEGs were detected, and 21/26 DEGs with up-regulated expression in male prawn brain/ganglion. DEGs in this pathway are likely to be regulated by multiple LncRNAs in polypeptide folding and misfolded protein degradation in the different organs and sexes of the prawn. Our study lays a foundation for understanding the growth dimorphism controlled by nervous system, and is a valuable resource for sex-controlled breeding of prawns in the future.

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“…The ER is a calcium‐ion storage and unique protein synthesis mechanism that is distributed throughout neurons with the presence of multiple domains associated with different functions. One such domain is called EMC, which is located on the ER membrane 63,64 . The location of ER/EMC within neurons reveals their contribution to synaptic plasticity by regulating various cellular processes from protein synthesis to Ca 2+ signaling.…”

Section: The Functions Of Emcmentioning

confidence: 99%

“…In Caenorhabditis elegans , α1‐subunit folding initiates the biosynthesis of voltage‐gated Ca 2+ channels, and glycosylphosphatidylinositol anchoring connects Ca 2+ channels to EMC 65 . Due to the organization of presynaptic Ca 2+ channels and postsynaptic ionotropic receptors into nanostructured domains, the ER plays a crucial role in establishing cross‐synaptic molecular nanopillars to form effective neural communication 64 …”

Section: The Functions Of Emcmentioning

confidence: 99%

“…One such domain is called EMC, which is located on the ER membrane. 63,64 The location of ER/EMC within neurons reveals their contribution to synaptic plasticity by regulating various cellular processes from protein synthesis to Ca 2+ signaling. In Caenorhabditis elegans, α1subunit folding initiates the biosynthesis of voltage-gated Ca 2+ channels, and glycosylphosphatidylinositol anchoring connects Ca 2+ channels to EMC.…”

Section: Emc Regulates Ca 2+ Signalingmentioning

confidence: 99%

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ER membrane complex (EMC): Structure, functions, and roles in diseases

Zhu,

Zhang

2024

The FASEB Journal

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The endoplasmic reticulum (ER) is the largest membrane system in eukaryotic cells and is the primary site for the biosynthesis of lipids and carbohydrates, as well as for the folding, assembly, modification, and transport of secreted and integrated membrane proteins. The ER membrane complex (EMC) on the ER membrane is an ER multiprotein complex that affects the quality control of membrane proteins, which is abundant and widely preserved. Its disruption has been found to affect a wide range of processes, including protein and lipid synthesis, organelle communication, endoplasmic reticulum stress, and viral maturation, and may lead to neurodevelopmental disorders and cancer. Therefore, EMC has attracted the attention of many scholars and become a hot field. In this paper, we summarized the main contributions of the research of EMC in the past nearly 15 years, and reviewed the structure and function of EMC as well as its related diseases. We hope this review will promote further progress of research on EMC.

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Endoplasmic Reticulum in Metaplasticity: From Information Processing to Synaptic Proteostasis

Cited by 8 publications

References 235 publications

Full-Length Transcriptomes and Sex-Based Differentially Expressed Genes in the Brain and Ganglia of Giant River Prawn Macrobrachium rosenbergii

Full-Length Transcriptomes and Sex-Based Differentially Expressed Genes in the Brain and Ganglia of Giant River Prawn Macrobrachium rosenbergii

Full-length transcriptomes of brain and ganglia and sex-based differentially-expressed genes involved in growth dimorphism of giant river prawn Macrobrachium rosenbergii

ER membrane complex (EMC): Structure, functions, and roles in diseases

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