Endoplasmic reticulum stress-related secretory proteins as biomarkers of early myocardial ischemia-induced sudden cardiac deaths

Yu, Bokang; Xu, Chenchao; Tang, Xinru; Liu, Zheng; Lin, Xinyi; Meng, Hang; Cheng, Sheue-yann; Ma, Kaijun; Bi, Xiao; Li, Liliang

doi:10.1007/s00414-021-02702-z

Cited by 14 publications

(14 citation statements)

References 47 publications

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“…E.g., serum VCP level was higher in patients with acute coronary syndrome when compared to healthy control or chronic coronary syndrome [ 38 ]. Serum VCP level was increased in myocardial ischemia-induced sudden cardiac deaths when compared to matched control patients who died from non-cardiac causes [ 39 ]. These results corroborate with the current study where plasma VCP level is decreased in LACI patients with NAO.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Proteomics of Medium-Sized Extracellular Vesicle-Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers

Datta

Chen

Gao

et al. 2022

IJMS

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Lacunar infarction (LACI), a subtype of acute ischemic stroke, has poor mid- to long-term prognosis due to recurrent vascular events or incident dementia which is difficult to predict using existing clinical data. Herein, we aim to discover blood-based biomarkers for LACI as a complementary prognostic tool. Convalescent plasma was collected from forty-five patients following a non-disabling LACI along with seventeen matched control subjects. The patients were followed up prospectively for up to five years to record an occurrence of adverse outcome and grouped accordingly (i.e., LACI-no adverse outcome, LACI-recurrent vascular event, and LACI-cognitive decline without any recurrence of vascular events). Medium-sized extracellular vesicles (MEVs), isolated from the pooled plasma of four groups, were analyzed by stable isotope labeling and 2D-LC-MS/MS. Out of 573 (FDR < 1%) quantified proteins, 146 showed significant changes in at least one LACI group when compared to matched healthy control. A systems analysis revealed that major elements (~85%) of the MEV proteome are different from the proteome of small-sized extracellular vesicles obtained from the same pooled plasma. The altered MEV proteins in LACI patients are mostly reduced in abundance. The majority of the shortlisted MEV proteins are not linked to commonly studied biological processes such as coagulation, fibrinolysis, or inflammation. Instead, they are linked to oxygen-glucose deprivation, endo-lysosomal trafficking, glucose transport, and iron homeostasis. The dataset is provided as a web-based data resource to facilitate meta-analysis, data integration, and targeted large-scale validation.

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Section: Discussionmentioning

confidence: 99%

Quantitative Proteomics of Medium-Sized Extracellular Vesicle-Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers

Datta

Chen

Gao

et al. 2022

IJMS

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“…The positivity rates (higher than normal) of CK-MB and cTnI in patients with myocardial damage are 35% to 68% and 25% to 42%, respectively [ 17 ]. However, many factors can affect cTnI, CK-MB, and NT-probNP levels, and as biomarkers they are not perfect [ 1 , 3 , 18 – 21 ]. For example, CK-MB is found in the myocardium but also in brain tissues and skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

“…However, many factors can affect cTnI, CK-MB, and NT-proBNP release, and the positive expression rate of cTnI and CKMB is not 100% [ 1 , 2 ]. Moreover, cTnI is not stable enough, which may affect the determination [ 3 ], and the specificity of NT-probNP and CK-MB is low [ 1 , 2 ] and, therefore, they are not optimal biomarkers. Hence, the diagnosis of secondary myocardial damage is difficult.…”

Section: Introductionmentioning

confidence: 99%

Serum TP53 Protein Level as a Sensitive Biomarker for the Diagnosis of Myocardial Damage in Children

et al. 2022

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“…It has also been observed that there is a direct correlation between CA II activity and diabetes, in the sense that diabetic patients have higher values of this isoenzyme, while CA I isoenzyme, known for its implications in vasoconstriction and vasodilation, has increased activity in all patients with myocardial infarction, regardless of their diabetic status [ 30 , 31 , 32 ]. The high values of CA II are also correlated with the high values of cardiac markers, meaning that the enzyme can also be an indicator of the state of damage to the heart tissue [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Carbonic Anhydrase Isozymes and the Evolution of Myocardial Infarction in Diabetic Patients

Magheru

Maghiar

et al. 2022

Biology

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(1) Background: Myocardial infarction was, until recently, recognized as a major coronary event, often fatal, with major implications for survivors. According to some authors, diabetes mellitus is an important atherogenic risk factor with cardiac determinations underlying the definition of the so-called “diabetic heart”. The present study aims to establish a correlation between the evolution of myocardial infarction in diabetic patients, by determining whether lactic acid levels, the activity of carbonic anhydrase isoenzymes, and the magnitude of ST-segment elevation are correlated with the subsequent evolution of myocardial infarction. (2) Methods: The study analyzed 2 groups of 30 patients each: group 1 consisted of diabetic patients with acute myocardial infarction, and group 2 consisted of non-diabetic patients with acute myocardial infarction. Patients were examined clinically and paraclinical, their heart markers, lactic acid, and the activity of carbonic anhydrase I and II isozymes were determined. All patients underwent electrocardiogram and echocardiography analyses. (3) Results: The results showed that diabetics develop acute myocardial infarction more frequently, regardless of how much time has passed since the diagnosis. The value of myocardial necrosis enzymes was higher in diabetics than in non-diabetics, and acute coronary syndrome occurs mainly in diabetics with poor metabolic balance. Lethality rates in non-diabetic patients with lactic acid values above normal are lower than in diabetics. (4) Conclusions: Lactic acid correlated with the activity of isozyme I of carbonic dioxide which could be early markers of the prognosis and evolution of diabetic patients with acute myocardial infarction.

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Endoplasmic reticulum stress-related secretory proteins as biomarkers of early myocardial ischemia-induced sudden cardiac deaths

Cited by 14 publications

References 47 publications

Quantitative Proteomics of Medium-Sized Extracellular Vesicle-Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers

Quantitative Proteomics of Medium-Sized Extracellular Vesicle-Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers

Serum TP53 Protein Level as a Sensitive Biomarker for the Diagnosis of Myocardial Damage in Children

Correlation between Carbonic Anhydrase Isozymes and the Evolution of Myocardial Infarction in Diabetic Patients

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