2020
DOI: 10.1159/000506120
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Endoscopic and Pathological Characteristics of <b><i>Helicobacter pylori</i></b> Infection-Negative Early Gastric Cancer

Abstract: Background: The characteristics of Helicobacter pylori (HP) infection-negative gastric cancer (HPINGC) have not been well documented because of the rareness. The aim of this study was to classify HPINGC endoscopically and clinicopathologically. Methods: This retrospective study included 1,741 early gastric cancer lesions and evaluated their HP infection status. Expression levels of MUC5AC, MUC6, MUC2, CD10, p53, MIB-1, pepsinogen-I, H+/K+ ATPase, chromogranin A, E-cadherin, and gastrin were evaluated in tumors… Show more

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Cited by 15 publications
(28 citation statements)
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“…Specific morphologic characteristics of malignancy were described in detail in many publications. 7 , 15–18 These characteristics consist of a few parameters, mainly discolorations of the base of the ulcer and specific structure and appearance of the ulcer’s borders, along with their relations to the surrounding mucosa.…”
Section: Discussionmentioning
confidence: 99%
“…Specific morphologic characteristics of malignancy were described in detail in many publications. 7 , 15–18 These characteristics consist of a few parameters, mainly discolorations of the base of the ulcer and specific structure and appearance of the ulcer’s borders, along with their relations to the surrounding mucosa.…”
Section: Discussionmentioning
confidence: 99%
“…Age‐specific gastric cancer incidence and stage‐specific 5‐year survival rate were obtained from Japanese cancer statistics 10 . The responsibility rate of H. pylori infection for gastric cancer development was assumed to be 98% 2,3,4,5 . The incidence of gastric cancer in H. pylori ‐positive patients was estimated using the responsibility rate of H. pylori infection for gastric cancer development and the prevalence of H. pylori infection 2,3,4,5,12,16 .…”
Section: Methodsmentioning
confidence: 99%
“…More than half of the world's population is infected with Helicobacter pylori ( H. pylori ) 1 . H. pylori infection causes chronic atrophic gastritis, a common stage of progression to gastric cancer, and is responsible for 98% of the causes of gastric cancer in Japan 2,3,4,5 . Japan has the third highest age‐standardized rate for gastric cancer in the world 6 .…”
Section: Introductionmentioning
confidence: 99%
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“…Aufgrund nachgewiesener High-Grade-Dysplasie sowie einer Adenom-Karzinom-Sequenz von 12-47 % zeigt sich auch eine klinische Relevanz der Pylorusdrüsenadenome [3,5,10]. Pylorusdrüsenadenome, die nicht mit einer chronischen Gastritis assoziiert sind, sollten stets an die Möglichkeit des Vorliegens einer familiären adenomatösen Polyposie (FAP) denken lassen [8,11]. Aber auch im Rahmen eines Lynch-Syndroms, wie bei unserem Fall, können Pylorusadenome vorkommen [9].…”
Section: Diskussionunclassified